What is it about?
Proteins are important molecular agents that serve many important functions in and between living cells — in essence, they maintain life. Proteins act by binding to other molecules, both small, such as metabolites, and large, such as other proteins or DNA. We have investigated how the binding of a small molecule to a protein actually happens.
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Why is it important?
An improved understanding of how proteins bind ligands may be important as a next step for future development of pharmaceuticals or biotech applications.
Perspectives
It is a great pleasure to finally see this article published. We embarked on this project more than 15 years ago. Two generations of graduate students have put a lot of effort into this study. A huge thanks to my co-authors for staying with it for all this time!
Mikael Akke
Lunds Universitet
Read the Original
This page is a summary of: Ligand-induced protein transition state stabilization switches the binding pathway from conformational selection to induced fit, Proceedings of the National Academy of Sciences, March 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2317747121.
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