What is it about?
Nutrition affects all physiological processes, including those that regulate our immune system. We found that reducing food intake without malnutrition supported cooperation between cells of the immune system and good gut bacteria (the microbiota). This promoted host protection against dangerous infectious pathogens.
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Why is it important?
Our findings have major implications for the design of individually tailored nutritional intervention strategies aimed at preventing and treating infectious diseases. Further, the identification of defined members of the gut microbiota as determinants of immune responsiveness to nutritional interventions creates the opportunity to precisely modulate an individual’s microbiota to promote optimal therapeutic efficacy.
Perspectives
We provide important information on what type of diet or nutritional intervention promotes optimal immune responses
Nicholas Collins
Weill Cornell Medical College
Read the Original
This page is a summary of: Microbiota configuration determines nutritional immune optimization, Proceedings of the National Academy of Sciences, November 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2304905120.
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