What is it about?
Total 8 derivatives were synthesized by Fischer Esterification method. Physical & chemical characterization of derivatives were performed . Results of biological investigation revealed that all synthesized derivatives exhibited improved effects at different levels
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Why is it important?
The bacterial resistance rise is occurring worldwide and badly endangering antibiotics efficacy. Lack in the knowledge of regulation of antibiotics is a serious issue around the globe. Overuse of antibiotics results in the creation of deadly strains of resistant bacteria and even after so much advancement people are dying because of infection with resistant bacteria. Therefore, efficient development of new antibacterial agents remains paramount. There is a need of development of new drugs and derivatives of lead compound with better properties in field of science to overcome the prevailing resistance with present drugs.
Perspectives
As these synthetic moieties showed good activity against different gram positive and gram negative bacterial strains. So in future, these molecules could be used as template for designing more biologically active derivatives. Further modifications could be helpful in increasing the binding affinity and activity of these compound therefore enhancing their efficacy. Pre-clinical, toxicity and advance studies can be done in the field of science and medicine in future. Moreover mechanism of action of optimal compounds can be elucidated. Fisher esterification method can be applied to any other class of antibiotics as well. There is large area for more study and compound optimization, which may result in the creation of some potential antibacterial drugs to combat bacterial resistance in a variety of bacterial illnesses.
Saharish Khaliq
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This page is a summary of: Synthesis, antimicrobial and molecular docking study of structural analogues of 3-((5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, PLoS ONE, December 2022, PLOS,
DOI: 10.1371/journal.pone.0278684.
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