What is it about?
Maresin 2 is a bio-active lipid that promotes repair of intestinal epithelial cells in injured colonic mucosa. Unfortunately, Maresin-2 is unstable, making it hard to use for therapeutic purposes. In this paper we not only demonstrate that Maresin-2 promotes migration and proliferation of epithelial cells but we also encapsulate Maresin-2 in nanoparticles to protect the lipid from degradation.
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Why is it important?
Our findings show that Maresin-2 has the potential to be used as a therapeutic option for conditions where intestinal mucosal injuries (such as ulcers) occur. Maresin-2 promotes migration of intestinal epithelial cells, decreasing the time a wound takes to heal. Of upmost importance is the fact that we increased Maresin-2 stability by encapsulating the lipid in nanoparticles that protect the lipid from degradation and with the capability of being lyophilized, which facilitates long-term storage without the requirement of specialized equipment.
Read the Original
This page is a summary of: Maresin-2 promotes mucosal repair and has therapeutic potential when encapsulated in thermostable nanoparticles, Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2218162120.
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