What is it about?

Pluripotency can be reinstated by chemistry-alone approach. Here we present an eye-catching movie of cell-fate transition: How small molecules directly harness cellular endogenous components to reprogram somatic cells into induced pluripotent stem cells.

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Why is it important?

Cellular reprogramming has fascinated the scientific community and general public for decades. As a breakthrough, chemical reprogramming has been achieved, but is still in its infancy, and the molecular understanding is very limited. Deciphering the underlying molecular mechanisms of chemical reprogramming will generate fundamental insights into cell-fate decisions and in turn can provide innovative strategies to make the reprogramming process rapid and efficient. Significantly, these efforts can be harnessed for generating functional cells for regenerative medicine, and also create a unique approach for realizing the dream of rejuvenation and regeneration.

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This page is a summary of: Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception, Proceedings of the National Academy of Sciences, May 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2215155120.
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