What is it about?
Rewiring of redox metabolism has a profound impact on tumor development, but how the cellular heterogeneity of redox balance affects leukemogenesis remains unknown. By establishing an in vivo redox monitoring tool at single-cell resolution, this work reveals a critical role of redox metabolism in leukemogenesis and a potential therapeutic target.
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Why is it important?
By using the H2O2 sensor (termed as HyPerion), we unravel a unique redox metabolic preference in maintaining the ROS level of AML cells. HyPerion-low AML cells have enhanced leukemogenic capacities, are enriched for functional leukemia-initiating cells, tend to localize in the endosteal niche and are more resistant to chemotherapy, which may be fine-tuned by malic enzyme ME1/3. Targeting ME1/3 can efficiently delay the AML development and overcome the drug resistance.
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This page is a summary of: Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells, Proceedings of the National Academy of Sciences, March 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2210796120.
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