What is it about?
Drugs that inflame the immune response have been delivered throughout the body in the past, leading to toxicity that limits the dose. We show here that anchoring interferons (a powerful natural immune stimulant) to a solid anchor within a tumor, leads to reduced toxicity and improved therapeutic efficacy.
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Why is it important?
We present here one example of a generalizable approach - precise control of immune stimulation could lead to safer and more effective cancer therapy.
Read the Original
This page is a summary of: Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2205983119.
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