What is it about?
Nucleosome tethering is a common mechanism used by viruses to attenuate host DNA-damage-response (DDR) signals and orchestrate viral life cycles. The Epstein-Barr virus tegument protein BKRF4 interacts with histone H2A–H2B via a histone chaperone-like sequence. The “triple-anchor” binding mode and a DWP motif confers BKRF4 a stronger H2A–H2B binding than many other H2A–H2B chaperones. Strikingly, BKRF4 only binds nucleosomes when they are partially disassembled and accumulates at DNA breaks, where chromatin needs to be disassembled prior to repair. Our findings reveal a histone chaperone mimicry strategy used by viruses to inhibit host DDR signaling.
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Why is it important?
This study reveals how BKRF4 bindings to the partially unfolded nucleosome and elucidates an unconventional mechanism of host antiviral signal attenuation.
Read the Original
This page is a summary of: Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses, Proceedings of the National Academy of Sciences, September 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2203782119.
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