What is it about?

We found that temperature memory in neurons adjusts the gut fat storages for acclimating to the environmental temperature. We found that neural circuits that circumnavigate the body from the head to the tail to back to the head act on the gut to regulate temperature acclimation by changing the gut fat amount.

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Why is it important?

Our result leads to the breakdown of fat retained in the intestine, and it is thought that when cultivated at high temperatures, the gut fat amount is reduced, making it less able to tolerate lower temperature.

Perspectives

Some mammals store fat in the fall for hibernation, and we expect that the novel brain-gut coupling we have found may lead to an understanding of temperature acclimation in higher animals.

Atsushi Kuhara
Konan University

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This page is a summary of: Head-tail-head neural wiring underlies gut fat storage in Caenorhabditis elegans temperature acclimation, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2203121119.
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