What is it about?
This work compares mice with normal immune systems to those with immune deficiencies for the study of human blood cell transfusion. Immunodeficient mice are shown to be better for this task and many experimental parameters are evaluated to optimize the study of blood products.
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Why is it important?
There are a limited means to study human blood products outside of human trials. Immunodeficient mice offer a means to study blood products and improve the practice of transfusion medicine.
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This page is a summary of: Immunodeficient mice are better for modeling the transfusion of human blood components than wild-type mice, PLoS ONE, July 2020, PLOS,
DOI: 10.1371/journal.pone.0237106.
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