What is it about?
Herpes simplex viruses can switch between lytic and latent infections, which is a lifelong source of recurrent diseases. We have uncovered, for the first time, a molecular network that controls the expression of a herpesvirus master regulator critical for viral replication or reactivation from latency.
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Why is it important?
Our findings provide a framework of virus-host regulatory circuits, which may help in the rational design of antiviral or oncolytic therapeutics.
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This page is a summary of: Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23, Proceedings of the National Academy of Sciences, December 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2113060118.
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