What is it about?
Gut bacteria often influence human health, but the mechanism is not very clear. By screening the genome of the bacteria E. coli, we found a set of bacterial genes that promote neurodegeneration in the host. By studying these genes, we show that bacteria can secrete an amyloid fibril called curli, which can enter neurons and serve as seeds to promote the aggregation of other proteins in neurons and cause neurodegeneration.
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Why is it important?
Our work uncovers a mechanistic link between gut bacteria and the progression of neurodegenerative diseases and suggests that targeting curli secretion in the gut may be a way to prevent or slow down neurodegeneration.
Read the Original
This page is a summary of: Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration, Proceedings of the National Academy of Sciences, August 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2106504118.
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