What is it about?

This papers demonstrates that hippocampal dopamine D1/D5 receptors control whether new object memories are linked to old ones through reconsolidation or whether they are consolidated as independent traces, and shows that the individual components of the recognition memory systems formed by reconsolidation can be destabilized even when indirectly reactivated.

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Why is it important?

Our findings show that dopamine couples novelty detection during recall to declarative memory destabilization and determines whether a new trace will be connected to an active network, ultimately defining its future susceptibility to indirect reactivation.


I hope people realize the clinical connotations of our results, in particular the idea that using declarative cues during psychotherapy might cause unwanted memory changes.

Martin Cammarota
Universidade Federal do Rio Grande do Norte

Read the Original

This page is a summary of: Dopamine controls whether new declarative information updates reactivated memories through reconsolidation, Proceedings of the National Academy of Sciences, July 2021, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2025275118.
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