What is it about?

Optical imaging technology for depth resolved visualization of the changes in sub-micron structure with nano-sensitivity is proposed and discussed. Results of numerical simulations and experimental imaging of phantoms and medico-biological objects, including human skin in vivo, confirm possibilities of the technique.

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Why is it important?

Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Presented technique permits noninvasive, label-free depth resolved detection of structural changes in biological samples with significant Improvement in sensitivity, up to nano-scale.


Proposed technique dramatically extends abilities of the conventional OCT to be sensitive to nanoscale structural alterations in space and in time. In addition, since it is non-invasive and no specific sample preparation is required, it can also be used as a complementary analysis to existing methods, making it particularly useful for research and early diagnostic purposes.

Dr Sergey Alexandrov
National University of Ireland - Galway

Read the Original

This page is a summary of: Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization, Applied Physics Letters, September 2019, American Institute of Physics, DOI: 10.1063/1.5110459.
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