What is it about?

This paper introduces a laboratory-based x-ray microscope for 3D imaging of soft tissue biopsies with micron and sub-micron resolution. The microscope uses intensity-modulation masks to access transmission, refraction and dark-field contrast channels. We demonstrated that the resolution of the microscope does not depend on source size or detector pixel pitch, but only on the mask aperture width.

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Why is it important?

This result breaks the link between the factors that traditionally determine spatial resolution in x-ray images (focal spot, detector pixel pitch) and the resolution level actually achieved in an image: this is pivotal for the development of a multi-resolution system where it would be possible to navigate across different sample scales by changing the mask aperture without other modifications.

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This page is a summary of: A laboratory-based, low-energy, multi-modal x-ray microscope with user-defined resolution, Applied Physics Letters, June 2022, American Institute of Physics, DOI: 10.1063/5.0082968.
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