What is it about?
I had written extensively about a damage provoked initiation of adaptive immunity before the "danger hypothesis" appeared in print. My submissions were repeatedly rejected until "Morphostasis and Immunity" was published by Medical Hypotheses (1995). This is my take on the defence of self/nonself views by those who saw little value in Polly Matzinger's "Danger" views.
Featured Image
Why is it important?
It starts to outline why a change in perspective is necessary and potentially revolutionary,
Perspectives
Eventyally, this series of articles leads to a Copernican style revolution in immune function. Rather than being a lympho-centric immune "universe" it leads to an inflammo-centric perspective where innate mechanisms are at the hub of the system.
Dr Jamie Cunliffe
Independant
Read the Original
This page is a summary of: From terra firma to terra plana – danger is shaking the foundations: deconstructing the ‘immune system’, Medical Hypotheses, March 1999, Elsevier,
DOI: 10.1054/mehy.1997.0645.
You can read the full text:
Resources
Contributors
The following have contributed to this page
