Platensimycin and its relatives: A recent story in the struggle to develop new naturally derived antibiotics

Muhammad Saleem, Hidayat Hussain, Ishtiaq Ahmed, Teunis van Ree, Karsten Krohn
  • Natural Product Reports, January 2011, Royal Society of Chemistry
  • DOI: 10.1039/c1np00010a

Platensimycin and its relatives

What is it about?

The isolation, occurrence, structure elucidation, chemical properties, biosynthesis and chemical synthesis of the naturally occurring antibiotics platensimycin, platencin, isoplatensimycin, platensimycin A1, and platensimycin B1–B3 are described. These antibiotics have a novel mode of action against multidrug resistant bacterial strains. Not only the naturally occurring molecules, but also their synthetic analogues are included in this review, with particular emphasis on the diverse approaches for chemical synthesis and the recent efforts to produce potentially more effective derivatives by chemical modification or total synthesis.

Why is it important?

Due to the appearance of antibiotic-resistant strains, there is a need to develop new antibiotics. Natural products are both fundamental sources of new chemical diversity and integral components of today’s pharmaceutical compendium. Platensimycin and platencin have been identified as attractive members for further investigation.

Perspectives

Professor Teunis van Ree
University of Venda

It is surprising how many different approaches to the synthesis and semisynthesis of this seemingly very difficult cage-like structure of platensimycin and analogues were accomplished in a relatively short time by creative scientists.

Read Publication

http://dx.doi.org/10.1039/c1np00010a

The following have contributed to this page: Hidayat Hussain and Professor Teunis van Ree