What is it about?
The paper is motivated by current needs of optical science and technology for biomedical and other applications and is devoted to an important fundamental problem: investigation of new possibilities to overcome the diffraction resolution barrier in far field without labels. We show a new way to break the diffraction resolution limit without using any labeling. As a result biological objects can be investigated in vivo, in their natural environment. The subwavelength resolution we demonstrated is based on the nano-sensitivity of our approach to internal structural changes. The ability to distinguish areas with different structure separated by 25 nm and resolve features of 50 nm size each, separated by 50 nm has been shown. Such technology can also be applied in other areas, including material science, nanotechnology, etc.
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Perspectives
The Nobel prize 2013 winner Thomas C. Südhof in his lecture at Photonics West 2015 in San Francisco pointed out that the number one challenge for our community is to make high resolution imaging more accessible and more usable in vitro and in vivo. I believe that our publication will be an important contribution to photonics and nanoscience and facilitate the community with new unique relatively simple and inexpensive tools for different applications, especially for in vitro and in vivo imaging in the fast emerging fields of bio- and nanotechnology.
Dr Sergey Alexandrov
National University of Ireland - Galway
Read the Original
This page is a summary of: Novel approach for label free super-resolution imaging in far field, Scientific Reports, September 2015, Nature,
DOI: 10.1038/srep13274.
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