What is it about?
ER stresses result in expansion of the ER volume and up-regulation of ER chaperones and folding enzymes. on resolution of the ER stress, induction of SEC62-regulated recovER-phagy re-establishes physiologic ER volume and chaperones concentration.
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Why is it important?
The manuscript describes a novel pathway for receptor-mediated delivery of ER fragments to endolysosomes for clearance.
Perspectives
Understand the mechanisms regulating induction and progression of ER turnover is crucial to find therapeutic approaches to deal with diseases caused by ER dysfunction, protein misfolding, ER stress.
Maurizio Molinari
Institute for Research in Biomedicine, Bellinzona, Switzerland
Read the Original
This page is a summary of: Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery, Nature Cell Biology, October 2016, Springer Science + Business Media,
DOI: 10.1038/ncb3423.
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