What is it about?

Carcinoma of unknown primary site (CUP) refers to 1–5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. The study presents diagnostic difficulties and the methods of diagnosing and the therapy of CUP and primary sites.

Featured Image

Why is it important?

CUP patients have often negative results of biopsy and imaging tests. Some procedures give a possibility of detecting the primary site and improves the results of treatment and survival of CUP patients. Combined therapy, including surgical treatment and chemoradiotherapy, gives the best therapeutic results in CUP patients.


I hope this article brings us closer to establishing guidelines for patients with CUP.

Tomasz Zatonski
Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu

Read the Original

This page is a summary of: The impact of the patient’s condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients, Cancer Management and Research, July 2019, Dove Medical Press,
DOI: 10.2147/cmar.s204346.
You can read the full text:

Open access logo


The following have contributed to this page