What is it about?

Here, we provide a meta-analytic assessment of 25 randomized controlled trials, and summarize cannabis-related pain reduction and placebo-related pain reduction across studies.

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Why is it important?

Pain, and opioid-based medicines used to treat pain, are associated with a rising economic burden in the United States. As such, add-on or alternative therapeutic options are desired. Cannabinoids have shown promise regarding pain management.


Although our meta-analysis results suggest that cannabinoids are efficacious pain management options, more research is needed. For example, our follow-up meta-regression results revealed that study sample size was associated with observed pain reduction, such that smaller samples were associated with bigger effects. Thus, large (i.e., sufficiently powered) studies are warranted.

Julio Yanes
Auburn University

Read the Original

This page is a summary of: Effects of cannabinoid administration for pain: A meta-analysis and meta-regression., Experimental and Clinical Psychopharmacology, May 2019, American Psychological Association (APA),
DOI: 10.1037/pha0000281.
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