What is it about?
Alcohol use disorder (AUD) is a major problem of our society and is often characterized and worsened by relapse. Prolonged alcohol exposure leads to numerous biochemical alterations that, upon cessation of alcohol intake, cause an array of immediate and lasting withdrawal symptoms. Acute withdrawal and neuroinflammation can be harmful in themselves, and lasting withdrawal symptoms contribute to relapse. Here, we conducted an initial feasibility study assessing several behavioral and neurochemical factors in female C3H/HeNRj (C3H) and C57BL/6JRj (B6) mice to determine which strain showed the clearest alcohol withdrawal symptoms during long-term abstinence and neurochemical alterations following re-exposure.
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Why is it important?
The feasibility of these assays is important because long-lasting withdrawal symptoms are often the main cause of relapse in alcohol-dependent patients. While similar studies have been done before, there is a lack of data on female subjects.
Perspectives
These pilot studies will allow us to test potential treatments for alcohol withdrawal symptoms and alcohol use disorder.
Morgane Thomsen
Region Hovedstaden
Read the Original
This page is a summary of: Behavioral and biochemical effects of alcohol withdrawal in female C3H/HeNRj and C57BL/6JRj mice, Frontiers in Behavioral Neuroscience, February 2023, Frontiers,
DOI: 10.3389/fnbeh.2023.1143720.
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