What is it about?
We studied the pharmacokinetics and tissue distribution of 4, 5-dimethoxycanthin-6-one and its major 2 metabolites following intramuscular administration of 4, 5-dimethoxycanthin-6-one to rats. The results show that 4, 5-dimethoxycanthin-6-one is rapidly absorbed and widely distributed in the selected tissues. Furthermore, the pharmacokinetics of 4, 5-dimethoxycanthin-6-one is characterized by the first order kinetics. The level of 4, 5-dimethoxycanthin-6-one in liver is the highest and those in the other tested tissues were much lower and comparable.
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Why is it important?
In this study, a validated LC–MS/MS method was successfully applied to study the pharmacokinetics and tissue distribution of 4,5-dimethoxycanthin-6-one and its major metabolites M1 and M2 in rats
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. We applied a validated LC-MS/MS method to study the pharmacokinetics and tissue distribution of 4,5-dimethoxycanthin-6-one and its major metabolites M1 and M2 in rats.This method provides new ideas for the research of drugs.
Yong Chen
Hubei University
Read the Original
This page is a summary of: Pharmacokinetics and tissue distribution of 4,5-dimethoxycanthin-6-one and its major metabolites in rats, Journal of Pharmaceutical and Biomedical Analysis, May 2017, Elsevier,
DOI: 10.1016/j.jpba.2017.01.015.
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