What is it about?

101BHG-D01 is a novel selective anti-muscarinic (M) 3 receptor blocking drug. 101BHG-D01 nasal spray is intended to be used to relieve sneezing and runny nose symptoms caused by allergic rhinitis. In this study, we examined the plasma pharmacokinetics, tissue distribution and major excretion mode of 101BHG-D01 in Beagle dogs and rats following nasal spray and intranasal administration respectively using HPLC-MS/MS. We found that the pharmacokinetics of 101BHG-D01 were linear in dogs. 101BHG-D01 entered bloodstream rapidly following nasal spray. Its plasma half-life was approximately 6 h, and resided at least 24 h in the body. Moreover, 101BHG-D01 retained a significant amount in the nasal cavity. Finally, we found that 101BHG-D01 was eliminated mainly in the form of stools in rats.

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Why is it important?

We provided pertinent reference information for the design and optimization of drug delivery regimens for clinical trials.


I hope this article makes studying drug metabolism interesting, even exciting. Because we have a lot to worry about when it comes to safe drug use, it's an issue that touches every single person on this planet in one way or another. Most importantly, I hope you can do your part to help with the safe use of drugs.

Hao Wei

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This page is a summary of: Pharmacokinetics and Tissue Distribution of Nasal Spray of a Novel Muscarinic Receptor Blocker, 101BHG-D01, in Dogs and Rats, Current Drug Metabolism, November 2022, Bentham Science Publishers, DOI: 10.2174/1389200224666221201123254.
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