What is it about?
Synthesis, biological studies and conformational analysis of cyclic RGD peptides as integrin ligands targeting angiogenesis in cancer
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Why is it important?
The development of bioactive RGD integrin ligands is an active field of research to deliver new molecular entities for targeted therapy in cancer. Such compounds are able to deliver conjugated drugs selectively to tumor cells overexpressing integrins.
Perspectives
Bioconjugation of the RGD cyclopeptide herein developed with drugs or chemical probes for applications in targeted therapy and molecular imaging.
Prof Andrea Trabocchi
University of Florence
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This page is a summary of: Morpholine-based RGD-cyclopentapeptides as αvβ3/αvβ5 integrin ligands: Role of configuration towards receptor binding affinity, Bioorganic & Medicinal Chemistry, February 2009, Elsevier,
DOI: 10.1016/j.bmc.2009.01.006.
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