All Stories

  1. Gold Nanostars Bioconjugation for Selective Targeting and SERS Detection of Biofluids

    Article • Nanomaterials, March 2021, MDPI AG

    Prof Andrea Trabocchi

  2. Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II

    Article • European Journal of Medicinal Chemistry, March 2021, Elsevier

    Prof Andrea Trabocchi

  3. Occurrence of Morpholine in Central Nervous System Drug Discovery

    Article • ACS Chemical Neuroscience, January 2021, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  4. Discovery of a d-pro-lys peptidomimetic inhibitor of MMP9: Addressing the gelatinase selectivity beyond S1′ subsite

    Article • Bioorganic & Medicinal Chemistry Letters, October 2020, Elsevier

    Prof Andrea Trabocchi

  5. Recent advances in copper-catalyzed imine-based multicomponent reactions

    Article • Tetrahedron Letters, July 2020, Elsevier

    Prof Andrea Trabocchi

  6. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

    Article • Molecules, June 2020, MDPI AG

    Assoc. Prof. Alfonso T. Garcia-Sosa, Prof Andrea Trabocchi, Dr Jean Jacques Vanden Eynde

  7. A Glucose‐Derived α‐Hydroxy Aldehyde for the Petasis Reaction: Facile Access to Polyfunctional δ‐Amino Acids

    Article • European Journal of Organic Chemistry, June 2020, Wiley

    Prof Andrea Trabocchi

  8. Nanostars—decorated microfluidic sensors for surface enhanced Raman scattering targeting of biomolecules

    Article • Journal of Physics Photonics, May 2020, Institute of Physics Publishing

    Prof Andrea Trabocchi

  9. Combination of multicomponent KA2 and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

    Article • Beilstein Journal of Organic Chemistry, February 2020, Beilstein Institut

    Prof Andrea Trabocchi

  10. Peptidomimetic toolbox for drug discovery

    Article • Chemical Society Reviews, January 2020, Royal Society of Chemistry

    Prof Andrea Trabocchi

  11. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

    Article • Molecules, December 2019, MDPI AG

    Assoc. Prof. Alfonso T. Garcia-Sosa, Prof Andrea Trabocchi, Dr Jean Jacques Vanden Eynde

  12. Copper-Catalyzed A3 -Coupling for the Diversity-Oriented Synthesis of Proline-Derived Alkynyl-Substituted Peptidomimetic Scaffolds

    Article • European Journal of Organic Chemistry, September 2019, Wiley

    Prof Andrea Trabocchi

  13. Identification of highly potent and selective MMP2 inhibitors addressing the S1′ subsite with d-proline-based compounds

    Article • Bioorganic & Medicinal Chemistry, May 2019, Elsevier

    Prof Andrea Trabocchi

  14. Occurrence of the d-Proline Chemotype in Enzyme Inhibitors

    Article • Symmetry, April 2019, MDPI AG

    Prof Andrea Trabocchi

  15. Smart Design of Small‐Molecule Libraries: When Organic Synthesis Meets Cheminformatics

    Article • ChemBioChem, March 2019, Wiley

    Prof Andrea Trabocchi

  16. Bicyclic acetals: biological relevance, scaffold analysis, and applications in diversity-oriented synthesis

    Article • Organic & Biomolecular Chemistry, January 2019, Royal Society of Chemistry

    Prof Andrea Trabocchi

  17. Exploring the chemical space and the bioactivity profile of lactams: a chemoinformatic study

    Article • RSC Advances, January 2019, Royal Society of Chemistry

    Prof Andrea Trabocchi

  18. Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle

    Article • Scientific Reports, April 2018, Springer Science + Business Media

    Dr Irene Stefanini, Prof Andrea Trabocchi

  19. Dual Iminium- and Lewis Base Catalyzed Morita–Baylis–Hillman Reaction on Cyclopent-2-enone

    Article • Synlett, December 2017, Thieme Publishing Group

    Prof Andrea Trabocchi

  20. Corrigendum to “Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors” [Bioorg. Med. Chem. 25 (2017) 5077–5083]

    Article • Bioorganic & Medicinal Chemistry, December 2017, Elsevier

    Prof Andrea Trabocchi

  21. Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors

    Article • Bioorganic & Medicinal Chemistry, October 2017, Elsevier

    Prof Andrea Trabocchi

  22. Design and synthesis of bioactive compounds

    Article • Bioorganic & Medicinal Chemistry, October 2017, Elsevier

    Prof Andrea Trabocchi

  23. Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae

    Article • Frontiers in Pharmacology, March 2017, Frontiers

    Dr Irene Stefanini, Prof Andrea Trabocchi

  24. Short synthesis of polyfunctional sp3-rich threonine-derived morpholine scaffolds

    Article • Organic & Biomolecular Chemistry, January 2017, Royal Society of Chemistry

    Prof Andrea Trabocchi

  25. Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

    Article • Molecules, October 2016, MDPI AG

    Prof Andrea Trabocchi

  26. Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells

    Article • Molecular and Cellular Biochemistry, October 2016, Springer Science + Business Media

    Prof Andrea Trabocchi

  27. Insight to the binding mode of triazole RGD-peptidomimetics to integrin-rich cancer cells by NMR and molecular modeling

    Article • Bioorganic & Medicinal Chemistry, March 2016, Elsevier

    Prof Andrea Trabocchi

  28. Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αVβ3 and α5β1 integrin ligands

    Article • Bioorganic & Medicinal Chemistry, February 2016, Elsevier

    Prof Andrea Trabocchi

  29. Carbohydrates in diversity-oriented synthesis: challenges and opportunities

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Prof Andrea Trabocchi

  30. Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis

    Article • Bioorganic & Medicinal Chemistry, March 2015, Elsevier

    Prof Andrea Trabocchi

  31. Skeletal Diversity from Carbohydrates: Use of Mannose for the Diversity-Oriented Synthesis of Polyhydroxylated Compounds

    Article • The Journal of Organic Chemistry, February 2015, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  32. A study of ad-proline peptidomimetic inhibitor of melanoma and endothelial cell invasion through activity towards MMP-2 and MMP-9

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Prof Andrea Trabocchi

  33. Two-step one-pot synthesis of dihydropyrazinones as Xaa-Ser dipeptide isosteres through morpholine acetal rearrangement

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Prof Andrea Trabocchi

  34. Role of Side-Chain Bioisosteres in Determining the Binding Affinity of Click Chemistry Derived RGD Peptidomimetics to αvβ3Integrin

    Article • European Journal of Organic Chemistry, October 2014, Wiley

    Prof Andrea Trabocchi

  35. Diversity-Oriented Synthesis as a Tool for Chemical Genetics

    Article • Molecules, October 2014, MDPI AG

    Prof Andrea Trabocchi

  36. Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, September 2014, Taylor & Francis

    Prof Andrea Trabocchi

  37. Identification of constrained peptidomimetic chemotypes as HIV protease inhibitors

    Article • European Journal of Medicinal Chemistry, September 2014, Elsevier

    Prof Andrea Trabocchi

  38. Combination of click chemistry and sulfonamides to develop three-armed triazole compounds

    Article • Tetrahedron, September 2014, Elsevier

    Prof Andrea Trabocchi

  39. Cyclopropane Pipecolic Acids as Templates for Linear and Cyclic Peptidomimetics: Application in the Synthesis of an Arg-Gly-Asp (RGD)-Containing Peptide as an αvβ3Integrin Ligand

    Article • Chemistry - A European Journal, July 2014, Wiley

    Prof Andrea Trabocchi

  40. Use of Click-Chemistry in the Development of Peptidomimetic Enzyme Inhibitors

    Article • Current Medicinal Chemistry, March 2014, Bentham Science Publishers

    Prof Andrea Trabocchi

  41. Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

    Article • Journal of Pharmacy and Pharmacology, March 2014, Oxford University Press (OUP)

    Prof Andrea Trabocchi

  42. Peptidomimetics in Organic and Medicinal Chemistry

    Article • February 2014, Wiley

    Prof Andrea Trabocchi

  43. Heterocyclic HIV-Protease Inhibitors

    Article • Current Medicinal Chemistry, August 2013, Bentham Science Publishers

    Prof Andrea Trabocchi

  44. Diversity-Oriented Synthesis

    Article • July 2013, Wiley

    Prof Andrea Trabocchi

  45. Diversity-Oriented Synthesis of Amino Acid-Derived Scaffolds and Peptidomimetics: A Perspective

    Article • June 2013, Wiley

    Prof Andrea Trabocchi

  46. Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype

    Article • Bioorganic & Medicinal Chemistry, December 2012, Elsevier

    Prof Andrea Trabocchi

  47. Synthesis and conformational studies of a hybrid β-alanine–morpholine tetramer

    Article • Tetrahedron, November 2012, Elsevier

    Prof Andrea Trabocchi

  48. d-Proline-based peptidomimetic inhibitors of anthrax lethal factor

    Article • European Journal of Medicinal Chemistry, October 2012, Elsevier

    Prof Andrea Trabocchi

  49. Insight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicansinhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, July 2012, Taylor & Francis

    Prof Andrea Trabocchi

  50. 125I-Radiolabeled Morpholine-Containing Arginine–Glycine–Aspartate (RGD) Ligand of αvβ3 Integrin As a Molecular Imaging Probe for Angiogenesis

    Article • Journal of Medicinal Chemistry, June 2012, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  51. One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: synthesis of model benzodiazepine(di)ones promoted by microwave irradiation

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Prof Andrea Trabocchi

  52. Synthesis of diverse phenylglycine derivatives via transformation of Ugi four-component condensation primary adducts

    Article • Tetrahedron Letters, May 2011, Elsevier

    Prof Andrea Trabocchi

  53. A New Family of Cinchona-Derived Amino Phosphine Precatalysts: Application to the Highly Enantio- and Diastereoselective Silver-Catalyzed Isocyanoacetate Aldol Reaction

    Article • Journal of the American Chemical Society, January 2011, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  54. Novel small molecules for the treatment of infections caused byCandida albicans: a patent review (2002 – 2010)

    Article • Expert Opinion on Therapeutic Patents, January 2011, Informa Healthcare

    Prof Andrea Trabocchi

  55. Chemical genetics approach to drug discovery by diversity-oriented synthesis (DOS) of peptidomimetics

    Article • Pure and Applied Chemistry, January 2011, De Gruyter

    Prof Andrea Trabocchi

  56. Skeletal diversity by sequential one-pot and stepwise routes using morpholine ester scaffolds

    Article • Tetrahedron Letters, December 2010, Elsevier

    Prof Andrea Trabocchi

  57. Click-Chemistry-Derived Triazole Ligands of Arginine−Glycine−Aspartate (RGD) Integrins with a Broad Capacity To Inhibit Adhesion of Melanoma Cells and Both in Vitro and in Vivo Angiogenesis

    Article • Journal of Medicinal Chemistry, September 2010, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  58. A Systems Biology Approach to Dissection of the Effects of Small Bicyclic Peptidomimetics on a Panel of Saccharomyces cerevisiae Mutants

    Article • Journal of Biological Chemistry, May 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Prof Andrea Trabocchi, Dr Irene Stefanini

  59. Identification of Inhibitors of Drug-Resistant Candida albicans Strains from a Library of Bicyclic Peptidomimetic Compounds

    Article • Journal of Medicinal Chemistry, February 2010, American Chemical Society (ACS)

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  60. Chemical genetics approach to identify new small molecule modulators of cell growth by phenotypic screening of Saccharomyces cerevisiae strains with a library of morpholine-derived compounds

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Prof Andrea Trabocchi, Dr Irene Stefanini

  61. Evaluation of stereochemically dense morpholine-based scaffolds as proline surrogates in β-turn peptides

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Prof Andrea Trabocchi

  62. Synthesis of γ‐ and δ‐Amino Acids

    Article • August 2009, Wiley

    Prof Andrea Trabocchi

  63. Diversity-Oriented Synthesis of Morpholine-Containing Molecular Scaffolds

    Article • Chemistry - A European Journal, August 2009, Wiley

    Prof Andrea Trabocchi

  64. Configurationally driven folding of model tetrapeptides containing L- or D-morpholine-3-carboxylic acids as β-turn nucleators

    Article • Chirality, June 2009, Wiley

    Prof Andrea Trabocchi

  65. Cyclic DGR-peptidomimetic containing a bicyclic reverse turn inducer as a selective αvβ5 integrin ligand

    Article • Amino Acids, March 2009, Springer Science + Business Media

    Prof Andrea Trabocchi

  66. Synthesis of cyclic peptide as a potent integrin ligand targeting angiogenesis

    Article • Bioorganic & Medicinal Chemistry, February 2009, Elsevier

    Prof Andrea Trabocchi

  67. Dimethoxyacetaldehyde

    Article • September 2008, Wiley

    Prof Andrea Trabocchi

  68. Synthesis of a bicyclic δ-amino acid as a constrained Gly-Asn dipeptide isostere

    Article • Amino Acids, January 2008, Springer Science + Business Media

    Prof Andrea Trabocchi

  69. Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Prof Andrea Trabocchi

  70. LiNTf 2 -Catalyzed Aminolysis of Lactones with Stoichiometric Quantities of Amines

    Article • Synlett, January 2008, Thieme Publishing Group

    Prof Andrea Trabocchi

  71. Diastereoselective Synthesis of Highly Constrained Spiro-β-Lactams by the Staudinger Reaction Using an Unsymmetrical Bicyclic Ketene

    Article • European Journal of Organic Chemistry, September 2007, Wiley

    Prof Andrea Trabocchi

  72. Structural diversity of bicyclic amino acids

    Article • Amino Acids, August 2007, Springer Science + Business Media

    Prof Andrea Trabocchi

  73. Convenient Route to Enantiopure Fmoc-Protected Morpholine-3-carboxylic Acid

    Article • The Journal of Organic Chemistry, April 2007, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  74. Synthesis and Conformational Analysis of Constrained β-Turn Mimetics Incorporating a Bicyclic Turn Inducer by Use of the Petasis Three-Component Reaction on Solid Phase

    Article • European Journal of Organic Chemistry, April 2007, Wiley

    Prof Andrea Trabocchi

  75. Synthesis of a Bicyclic Proline Analogue from l -Ascorbic Acid

    Article • Synthesis, September 2006, Thieme Publishing Group

    Prof Andrea Trabocchi

  76. 3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter

    Article • Bioorganic & Medicinal Chemistry, August 2006, Elsevier

    Prof Andrea Trabocchi

  77. 3-Aza-8,10-dioxa-bicyclo[5.2.1]decane (9-exo BTKa) carboxylic acid as a new reverse turn inducer: synthesis and conformational analysis of a model peptide

    Article • Tetrahedron, February 2006, Elsevier

    Prof Andrea Trabocchi

  78. Design, Synthesis, and Applications of 3-Aza-6,8-Dioxabicyclo[3.2.1]Octane-Based Scaffolds for Peptidomimetic Chemistry

    Article • Synlett, January 2006, Thieme Publishing Group

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  79. Synthesis of a constrained tricyclic scaffold based on trans-4-hydroxy-l-proline

    Article • Tetrahedron Letters, November 2005, Elsevier

    Prof Andrea Trabocchi

  80. Synthesis of Glycidol- and Sugar-Derived Bicyclic β- and γ/δ-Amino Acids for Peptidomimetic Design

    Article • European Journal of Organic Chemistry, October 2005, Wiley

    Prof Andrea Trabocchi

  81. γ- and δ-Amino Acids: Synthetic Strategies and Relevant Applications

    Article • Current Organic Chemistry, August 2005, Bentham Science Publishers

    Prof Andrea Trabocchi

  82. Solvent-Dependent Conformational Behaviour of Model Tetrapeptides Containing a Bicyclic Proline Mimetic

    Article • European Journal of Organic Chemistry, November 2004, Wiley

    Prof Andrea Trabocchi

  83. Enantiospecific synthesis of 3-aza-6,8-dioxa-bicyclo[3.2.1]octane carboxylic acids from erythrose

    Article • Tetrahedron, July 2003, Elsevier

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  84. A new bicyclic proline-mimetic amino acid

    Article • Tetrahedron Letters, April 2003, Elsevier

    Prof Andrea Trabocchi

  85. Synthesis of a new enantiopure bicyclic γ/δ-amino acid (BTKa) derived from tartaric acid and α-amino acetophenone

    Article • Tetrahedron, December 2002, Elsevier

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  86. Synthesis and Conformational Analysis of Small Peptides Containing 6-Endo-BT(t)L Scaffolds as Reverse Turn Mimetics

    Article • The Journal of Organic Chemistry, September 2002, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  87. Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5α-reductase 1

    Article • Bioorganic & Medicinal Chemistry, June 2001, Elsevier

    Prof Andrea Trabocchi, Dr Fabrizio Machetti

  88. Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor

    Article • Bioorganic & Medicinal Chemistry, June 2001, Elsevier

    Prof Andrea Trabocchi

  89. Suzuki Reaction of Vinyl Triflates from Six- and Seven-Membered N-Alkoxycarbonyl Lactams with Boronic Acids and Esters

    Article • The Journal of Organic Chemistry, March 2001, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  90. Pd(0)-Catalyzed Cross-Coupling Reactions of Boron Derivatives with a Lactam-Derived N-Boc Enol Triflate

    Article • Organic Letters, April 2000, American Chemical Society (ACS)

    Prof Andrea Trabocchi

  91. A solid-phase approach towards the development of 3-aza-6,8-dioxabicyclo[3.2.1]octane scaffolds

    Article • Molecular Diversity, January 2000, Springer Science + Business Media

    Prof Andrea Trabocchi

  92. Synthesis and Reactivity of Bicycles Derived from Tartaric Acid and α-Amino Acids:  A Novel Class of Conformationally Constrained Dipeptide Isosteres Based upon Enantiopure 3-Aza-6,8-dioxabicyclo[3.2.1]octane-7-carboxylic Acid

    Article • The Journal of Organic Chemistry, September 1999, American Chemical Society (ACS)

    Prof Andrea Trabocchi, Dr Fabrizio Machetti