What is it about?
Uncontrolled inflammation leads to several diseases such as insulin resistance, T2D and several types of cancers. The functional role of microRNAs in inflammation induced insulin resistance is poorly studied. MicroRNAs are post-transcriptional regulatory molecules which mediate diverse biological processes.
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Why is it important?
We here show that miR-16 expression levels are down-regulated in different inflammatory conditions such as LPS/IFNg or palmitate treated macrophages, palmitate exposed myoblasts and insulin responsive tissues of high sucrose diet induced insulin resistant rats. Importantly, forced expression of miR-16 in macrophages impaired the production of TNF-a, IL-6 and IFN-b leading to enhanced insulin stimulated glucose uptake in co-cultured skeletal myoblasts.
Perspectives
Ectopic expression of miR-16 enhanced insulin stimulated glucose uptake in skeletal myoblasts via the up-regulation of GLUT4 and MEF2A, two key players involved in insulin stimulated glucose uptake. Collectively, our data highlight the important role of miR-16 in ameliorating inflammation induced insulin resistance.
Dr Sriram Seshadri
Nirma University of Science and Technology
Read the Original
This page is a summary of: MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts, Biochimie, December 2015, Elsevier,
DOI: 10.1016/j.biochi.2015.10.004.
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