What is it about?
Our review aims to convey a broad and complex interplay between the frequently examined cells of the mesenchymal lineage -specifically adipocytes and osteoblasts- but to broaden this to include chondrocytes , as well as hematopoietic-derived osteoclasts.
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Why is it important?
In seeking to build on known interplay between diverse skeletal cell populations, we ask how interactions between a multitude of cells might be attenuated with non-pharmacologic, exercise and dietary based interventions for aging related conditions like osteoporosis and osteoarthritis.
Perspectives
Led by our fearless fellow Dr. Little-Letsinger, this review represents a unique examination of cross-talk between cells housed within the skeleton , and how exercise might reverse aspects of declines orchestrated in bone marrow. In addition to reviewing what is known, Dr. Little-Letsinger leads us through tremendous gaps and unknowns that we hope will drive novel work in the field.
Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology
Read the Original
This page is a summary of: Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis, Seminars in Cell and Developmental Biology, September 2021, Elsevier,
DOI: 10.1016/j.semcdb.2021.08.011.
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Resources
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NIH Reporter
Funding / Marrow Adipose Compartment Physiology in Caloric Restriction and Aging
Contributors
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