What is it about?
We found that the expression levels of pp38 and p62 are up-regulatedin LPS-induced BV2 cells and the MPTP-induced PD model. Meanwhile, miR-124 could suppress the secretion of proinflammatory mediators by targeting 62/p38 expression and promote autophagy in the inflammatory pathogenesis of PD.
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Why is it important?
Our data suggest that miR-124 can inhibit the neuroinflammation that occurs during the development of PD and implicate miR-124 as a potential therapeutic target for regulating the inflammatory response in PD.
Perspectives
miR-124 could be a potential therapeutic target for regulating the inflammatory response in PD.
Longping Yao
Southern Medical University
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This page is a summary of: MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease, The FASEB Journal, July 2019, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201900363r.
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