Metal mediated synthesis of 2-thiazolines

What is it about?

2-thiazolines are very important structural motifs in pharmaceuticals, agrochemicals and in chemistry. In this mini review, I tried to highlight the metal mediated synthetic strategies and challenges of 2-thiazolines based on the literature up to 2020. It was found that most of these protocols involved the formation of both C-N and C-S bonds and the major challenges were the stereochemistry at C-4 position and C(2)-exomethine position. Moreover, the development of asymmetric processes was completely overlooked and hence the question arises -how could the site of selectivity be improved to get access to the desired structural units?

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Photo by Hans Reniers on Unsplash

Photo by Hans Reniers on Unsplash

Why is it important?

Various research groups have paid attention in last few decades to get access of stereochemically vibrant structures of 2-thiazolines due to their extensive applications in pharmaceuticals, agrochemicals and in chemistry. Metal-catalyzed reactions are often considered to achieve high molecular complexity and greater functional group compatibilities from easily accessible starting materials under milder reaction conditions and atom economical fashions. It is conceivable that a semi-quantitative and qualitative overview of the ongoing works is necessary to help guide the future work in this area. Hence, we were most interested to learn the existing challenges, targets that driven the development of metal catalysts and the areas that were improved by those strategies.

Perspectives