What is it about?
a bench chemists guide to developments in Fmoc solid phase peptide chemistry. Although extremely powerful Fmoc solid phase synthesis has limitations, for example, the extreme sequence dependence of synthetic success. This review looks at current protecting groups, areas where innovation is required, cures for aspartimide formation and strategies against difficult sequences.
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Why is it important?
Although chemical peptide synthesis has had a huge impact on the biosciences it could be much better and make an even bigger impact. In this review we try to highlight what areas of peptide chemistry need to be improved. Peptide chemistry has become a victim of its own success with practitioners reluctant to adopt or test new technology.
Perspectives
solid phase peptide synthesis has matured to the point where it is routinely used for the industrial production of many short peptide drugs. However many aspects of it could still be improved. The very success of Fmoc synthesis has prevented further innovation as the Fmoc building blocks are produced in such quantities for industry it is hard to add new products that are competitively priced with the existing ones. This review concentrates on the areas that are most promising for improvement and where advances are anticipated to make longer, purer peptides and the growing demand for modified peptides.
Dr john offer
Francis Crick Institute
Read the Original
This page is a summary of: Advances in Fmoc solid‐phase peptide synthesis, Journal of Peptide Science, January 2016, Wiley,
DOI: 10.1002/psc.2836.
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