What is it about?
Lutein is a kind of carotenoid which possesses a wide variety of biological activities such as antioxidative, anti-inflammatory and neuroprotective properties. However, it is unclear whether lutein could inhibit neuroinflammation in microglia cells. In this study, we investigated that lutein could efficiently attenuate neuroinflammation in BV-2 microglia. The protective effects of lutein against neuroinflammation were based on its potent anti-inflammatory and antioxidative activities.
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Why is it important?
Microglia are the resident immune surveillance cells of the central nervous system. Aberrantly activated microglial cells could induce neuroinflammation and lead to neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease. Therefore, suppressing the aberrant activation of microglia may have valuable therapeutic potential for the treatment of neuroinflammation related neurodegenerative diseases. In this study, we investigated that lutein could efficiently attenuate neuroinflammation in BV-2 microglia, suggesting that lutein has great potential as a nutritional preventive strategy in inflammation-related neurodegenerative disorders.
Perspectives
Accumulating evidence suggests that aberrantly activated microglia produce excessive amounts of various pro-inflammatory mediators, which could lead to neuroinflammation and neurodegenerative diseases. Lutein is a kind of oxycarotenoid that possesses a wide variety of biological activities, such as antioxidative and anti-inflammatory capacities. Lutein tends to be the dominant carotenoid in central nervous tissues, and plays an important role in the development and function of central nervous tissues. In the present research, it was demonstrated that lutein pretreatment efficiently attenuated neuroinflammation in BV-2 microglia, which was based on its antioxidative and anti-inflammatory capacities. The results suggested that lutein has great potential as a nutritional preventive strategy in inflammation-related neurodegenerative disorders.
Professor Xuebo Liu
Northwest A&F University
Read the Original
This page is a summary of: Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia, Molecular Nutrition & Food Research, June 2015, Wiley,
DOI: 10.1002/mnfr.201500109.
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