What is it about?
How to understand monoclonal antibody aggregates removal by protein A chromatography in terms of affinity between a modified protein A ligand and hybrid- or homogenous aggregates.
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Why is it important?
Monoclonal antibody aggregates removal is essential for monoclonal antibody drug purification processes, which are usually complicated and non-efficient.
Perspectives
Professor, Yamaguchi University. Bio-Process Engineering Laboratory Yamaguchi University Bio-Medical Engineering Center(YUBEC) Sub Project Leader, Manufacturing Technology Association of Biologics (Consortium supported by AMED and METI, Japan)
Professor Shuichi Yamamoto
Yamaguchi University
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This page is a summary of: Choosing the right protein A affinity chromatography media can remove aggregates efficiently, Biotechnology Journal, October 2016, Wiley,
DOI: 10.1002/biot.201600427.
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