All Stories

  1. Integrated continuous downstream process of monoclonal antibody developed by converting the batch platform process based on the process characterization

    Article • Biotechnology and Bioengineering, September 2023, Wiley

    Professor Shuichi Yamamoto

  2. Viral clearance in end‐to‐end integrated continuous process for mAb purification: Total flow‐through integrated polishing on two columns connected to virus filtration

    Article • Biotechnology and Bioengineering, June 2023, Wiley

    Professor Shuichi Yamamoto

  3. Viral clearance in end-to-end continuous process for mAb purification: Total flow-through integrated polishing on two columns connected to virus filtration

    Article • February 2023, Wiley

    Professor Shuichi Yamamoto

  4. An accelerated approach for mechanistic model based prediction of linear gradient elution ion-exchange chromatography of proteins

    Article • Journal of Chromatography A, September 2022, Elsevier

    Professor Shuichi Yamamoto

  5. Measurement of High Protein Concentrations by Optical Rotation: A Case Study for Monitoring of Monoclonal Antibody Drug Downstream Processes

    Article • Current Protein and Peptide Science, December 2021, Bentham Science Publishers

    Professor Shuichi Yamamoto

  6. Linear flow‐velocity gradient chromatography—An efficient method for increasing the process efficiency of batch and continuous capture chromatography of proteins

    Article • Biotechnology and Bioengineering, January 2021, Wiley

    Professor Shuichi Yamamoto

  7. Prediction of the Performance of Capture Chromatography Processes of Proteins and Its Application to the Repeated Cyclic Operation Optimization

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, November 2020, Taylor & Francis

    Professor Shuichi Yamamoto

  8. Retention and diffusion characteristics of oligonucleotides in a solid phase with polymer grafted anion-exchanger

    Article • Journal of Chromatography A, October 2020, Elsevier

    Professor Shuichi Yamamoto

  9. Accelerated Method for Designing Flow-Through Chromatography of Proteins

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, May 2020, Taylor & Francis

    Professor Shuichi Yamamoto

  10. Optimization of Flow-Through Chromatography of Proteins

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, May 2020, Taylor & Francis

    Professor Shuichi Yamamoto

  11. Thermodynamic analysis of polyphenols retention in polymer resin chromatography by van’t Hoff plot and isothermal titration calorimetry

    Article • Journal of Chromatography A, December 2019, Elsevier

    Professor Shuichi Yamamoto

  12. Connected flow-through chromatography processes as continuous downstream processing of proteins

    Article • MATEC Web of Conferences, January 2019, EDP Sciences

    Professor Shuichi Yamamoto

  13. A method for designing flow-through chromatography processes

    Article • MATEC Web of Conferences, January 2019, EDP Sciences

    Professor Shuichi Yamamoto

  14. Retention Mechanism of Proteins in Hydroxyapatite Chromatography – Multimodal Interaction Based Protein Separations: A Model Study

    Article • Current Protein and Peptide Science, November 2018, Bentham Science Publishers

    Professor Shuichi Yamamoto

  15. Reaction-Mediated Desorption of Macromolecules: Novel Phenomenon Enabling Simultaneous Reaction and Separation

    Article • Biotechnology Journal, February 2018, Wiley

    Professor Shuichi Yamamoto

  16. A Statistical Model for Estimating the Effects of Oil Droplet Size and Oil Fraction in Microcapsules on Oxidation of Oil

    Article • European Journal of Lipid Science and Technology, October 2017, Wiley

    Professor Shuichi Yamamoto

  17. Effect of pore size on performance of monolithic tube chromatography of large biomolecules

    Article • Electrophoresis, October 2017, Wiley

    Professor Shuichi Yamamoto

  18. A simple method for calculating the productivity of polyphenol separations by polymer-based chromatography

    Article • Bioscience Biotechnology and Biochemistry, April 2017, Taylor & Francis

    Professor Shuichi Yamamoto

  19. Aggregate removal by protein A chromatography

    Article • Biotechnology Journal, October 2016, Wiley

    Professor Shuichi Yamamoto

  20. A Simple Method for Predicting the Adsorption Performance of Capture Chromatography of Proteins

    Article • Japan Journal of Food Engineering, January 2016, Japan Society for Food Engineering

    Professor Shuichi Yamamoto

  21. Monolith disk chromatography separates PEGylated protein positional isoforms within minutes at low pressure

    Article • Biotechnology Journal, December 2015, Wiley

    Professor Shuichi Yamamoto

  22. Salt tolerant chromatography provides salt tolerance and a better selectivity for protein monomer separations

    Article • Biotechnology Journal, November 2015, Wiley

    Professor Shuichi Yamamoto

  23. Drying Rates and Desorption Isotherms of Lemon Juice

    Article • Japan Journal of Food Engineering, January 2014, Japan Society for Food Engineering

    Professor Shuichi Yamamoto

  24. Effect of Reducing Oil Droplet Size on Lipid Oxidation in an Oil-in-water Emulsion

    Article • Japan Journal of Food Engineering, January 2014, Japan Society for Food Engineering

    Professor Shuichi Yamamoto

  25. Effects of Pre-Treatments on Browning of Lemon Peels during Drying

    Article • Japan Journal of Food Engineering, January 2014, Japan Society for Food Engineering

    Professor Shuichi Yamamoto

  26. Surface-oil Contents of Microcapsules with Different Oil Droplet-to-Microcapsule Size Ratios

    Article • Japan Journal of Food Engineering, January 2014, Japan Society for Food Engineering

    Professor Shuichi Yamamoto

  27. Enzyme Retention During Drying of Amorphous Sugar and Carbohydrate Solutions: Diffusion Model Revisited

    Article • Drying Technology, October 2013, Taylor & Francis

    Professor Shuichi Yamamoto

  28. High‐throughput process development methods for chromatography and precipitation of proteins: Advantages and precautions

    Article • Engineering in Life Sciences, August 2013, Wiley

    Professor Shuichi Yamamoto

  29. PEG chain length impacts yield of solid‐phase protein PEGylation and efficiency of PEGylated protein separation by ion‐exchange chromatography: Insights of mechanistic models

    Article • Biotechnology Journal, June 2013, Wiley

    Professor Shuichi Yamamoto

  30. Fast separation of large biomolecules using short monolithic columns

    Article • Journal of Chromatography B, May 2013, Elsevier

    Professor Shuichi Yamamoto

  31. Surface Oil Content of Microcapsules Containing Various Oil Fractions and Oil-Droplet Sizes

    Article • Japan Journal of Food Engineering, January 2013, Japan Society for Food Engineering

    Professor Shuichi Yamamoto

  32. PEGylated protein separations: Challenges and opportunities

    Article • Biotechnology Journal, April 2012, Wiley

    Professor Shuichi Yamamoto

  33. Drying of Yeasts—Factors Affecting Inactivation During Drying

    Article • Drying Technology, December 2011, Taylor & Francis

    Professor Shuichi Yamamoto

  34. Rational Method for Designing Efficient Chromatography Processes based on the Iso‐Resolution Curve

    Article • Chemical Engineering & Technology, November 2011, Wiley

    Professor Shuichi Yamamoto

  35. Peak spreading in linear gradient elution chromatography with a thin monolithic disk

    Article • Journal of Chromatography A, April 2011, Elsevier

    Professor Shuichi Yamamoto

  36. Editorial: Asia Pacific Biochemical engineering

    Article • Biotechnology Journal, May 2010, Wiley

    Prof. Minoru SEKI, Professor Shuichi Yamamoto

  37. Interaction mechanism of mono‐PEGylated proteins in electrostatic interaction chromatography

    Article • Biotechnology Journal, May 2010, Wiley

    Professor Shuichi Yamamoto

  38. Binding site and elution behavior of DNA and other large biomolecules in monolithic anion-exchange chromatography

    Article • Journal of Chromatography A, March 2009, Elsevier

    Professor Shuichi Yamamoto

  39. Theoretical background of monolithic short layer ion-exchange chromatography for separation of charged large biomolecules or bioparticles

    Article • Journal of Chromatography A, March 2009, Elsevier

    Professor Shuichi Yamamoto

  40. Diseases of protein aggregation and the hunt for potential pharmacological agents

    Article • Biotechnology Journal, February 2008, Wiley

    Professor Shuichi Yamamoto

  41. Micro-Plate Based Monolithic Ion-Exchange Chromatography for High Throughput Protein Purification Process Design

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, January 2008, Taylor & Francis

    Professor Shuichi Yamamoto

  42. Solid-Phase PEGylation of Recombinant Interferon α-2a for Site-Specific Modification: Process Performance, Characterization, andin VitroBioactivity

    Article • Bioconjugate Chemistry, October 2007, American Chemical Society (ACS)

    Professor Shuichi Yamamoto

  43. Effects of protein conformational changes on separation performance in electrostatic interaction chromatography: Unfolded proteins and PEGylated proteins

    Article • Journal of Biotechnology, October 2007, Elsevier

    Professor Shuichi Yamamoto

  44. Effects of Pretreatments of Sliced Vegetables with Trehalose on Drying Characteristics and Quality of Dried Products

    Article • Food and Bioproducts Processing, September 2007, Elsevier

    Professor Shuichi Yamamoto

  45. Application of a chromatography model with linear gradient elution experimental data to the rapid scale-up in ion-exchange process chromatography of proteins

    Article • Journal of Chromatography A, August 2007, Elsevier

    Professor Shuichi Yamamoto

  46. Rational method for designing efficient separations by chromatography on polystyrene–divinylbenzene resins eluted with aqueous ethanol

    Article • Journal of Chromatography A, August 2007, Elsevier

    Professor Shuichi Yamamoto

  47. The hydrophobic interactions of the ion-exchanger resin ligands with proteins at high salt concentrations by adsorption isotherms and isothermal titration calorimetry

    Article • Separation and Purification Technology, April 2007, Elsevier

    Professor Shuichi Yamamoto

  48. Retention studies of DNA on anion-exchange monolith chromatography

    Article • Journal of Chromatography A, March 2007, Elsevier

    Professor Shuichi Yamamoto

  49. Studies of the interaction mechanism between single strand and double-strand DNA with hydroxyapatite by microcalorimetry and isotherm measurements

    Article • Colloids and Surfaces A Physicochemical and Engineering Aspects, March 2007, Elsevier

    Professor Shuichi Yamamoto

  50. Water Diffusion and Desorption Behavior during Low-Temperature Drying of Foods

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, January 2007, Taylor & Francis

    Professor Shuichi Yamamoto

  51. Optimization of elution salt concentration in stepwise elution of protein chromatography using linear gradient elution data

    Article • Journal of Chromatography A, May 2006, Elsevier

    Professor Shuichi Yamamoto

  52. Rational Design Calculation Method for Stepwise Elution Chromatography of Proteins

    Article • Food and Bioproducts Processing, March 2006, Elsevier

    Professor Shuichi Yamamoto

  53. Electrostatic Interaction Chromatography Process for Protein Separations: Impact of Engineering Analysis of Biorecognition Mechanism on Process Optimization

    Article • Chemical Engineering & Technology, November 2005, Wiley

    Professor Shuichi Yamamoto

  54. Rational methods for predicting human monoclonal antibodies retention in protein A affinity chromatography and cation exchange chromatography

    Article • Journal of Chromatography A, November 2005, Elsevier

    Professor Shuichi Yamamoto

  55. Effects of Surface Concentration on Drying Behavior of Carbohydrate Solutions

    Article • Drying Technology, June 2005, Taylor & Francis

    Professor Shuichi Yamamoto

  56. Optimization of monoclonal antibody purification by ion-exchange chromatography

    Article • Journal of Chromatography A, March 2005, Elsevier

    Professor Shuichi Yamamoto

  57. Theoretical background of short chromatographic layers

    Article • Journal of Chromatography A, February 2005, Elsevier

    Professor Shuichi Yamamoto

  58. Effects of Pre-treatments on Rehydration Properties and Microscopic Structure Changes of Dried Vegetables

    Article • Japan Journal of Food Engineering, December 2004, Japan Society for Food Engineering

    Professor Shuichi Yamamoto

  59. Application of a simplified method based on regular regime approach to determine the effective moisture diffusivity of mixture of low molecular weight sugars and maltodextrin during desorption

    Article • Journal of Food Engineering, September 2002, Elsevier

    Professor Shuichi Yamamoto

  60. Drying of gelled sugar solutions—water diffusion behavior

    Article • Chemical Engineering Journal, February 2002, Elsevier

    Professor Shuichi Yamamoto

  61. A SHORT-CUT METHOD FOR DETERMINING CONCENTRATION DEPENDENT DIFFUSIVITY IN LIQUID FOODS AND POLYMER SOLUTIONS FROM REGULAR REGIME DRYING CURVES

    Article • Drying Technology, July 2001, Taylor & Francis

    Professor Shuichi Yamamoto

  62. Microcalorimetric studies of the interaction mechanisms between proteins and Q-Sepharose at pH near the isoelectric point (pI)

    Article • Journal of Chromatography A, April 2001, Elsevier

    Professor Shuichi Yamamoto

  63. Effects of adsorbent properties on zone spreading in expanded bed chromatography

    Article • Bioseparation, January 2001, Springer Science + Business Media

    Professor Shuichi Yamamoto

  64. Cleaning Liquid Consumption and Recycle of Biopharmaceutical Plant

    Article • January 2000, Elsevier

    Professor Shuichi Yamamoto

  65. Column Qualification in Process Ion-Exchange Chromatography

    Article • January 2000, Elsevier

    Professor Shuichi Yamamoto

  66. Dynamic binding performance of large biomolecules such as γ-globulin, viruses and virus-like particles on various chromatographic supports

    Article • January 2000, Elsevier

    Professor Shuichi Yamamoto

  67. Separation behavior of proteins near the isoelectric points in electrostatic interaction (ion exchange) chromatography

    Article • January 2000, Elsevier

    Professor Shuichi Yamamoto

  68. Characterization of unstable ion-exchange chromatographic separation of proteins

    Article • Journal of Chromatography A, August 1999, Elsevier

    Professor Shuichi Yamamoto

  69. Ion-exchange chromatography of proteins near the isoelectric points

    Article • Journal of Chromatography A, August 1999, Elsevier

    Professor Shuichi Yamamoto

  70. Retention behavior of very large biomolecules in ion-exchange chromatography

    Article • Journal of Chromatography A, August 1999, Elsevier

    Professor Shuichi Yamamoto

  71. Acetic Acid Separation from Anaerobically Treated Palm Oil Mill Effluent by Ion Exchange Resins for the Production of Polyhydroxyalkanoate byAlcaligenes eutrophus

    Article • Bioscience Biotechnology and Biochemistry, January 1997, Taylor & Francis

    Professor Shuichi Yamamoto

  72. Chromatographic separation of galactosylkojic acid

    Article • Journal of Fermentation and Bioengineering, January 1997, Elsevier

    Professor Shuichi Yamamoto

  73. Prediction of the preparative chromatography performance with a very small column

    Article • Journal of Chromatography A, January 1997, Elsevier

    Professor Shuichi Yamamoto

  74. Plate height determination for gradient elution chromatography of proteins

    Article • Biotechnology and Bioengineering, December 1995, Wiley

    Professor Shuichi Yamamoto

  75. Calculation of concentration dependent mutual diffusion coefficients for the penetration period of sorption process in polymer film.

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, January 1995, Taylor & Francis

    Professor Shuichi Yamamoto

  76. DRYING OF CARBOHYDRATE AND PROTEIN SOLUTIONS

    Article • Drying Technology, January 1994, Taylor & Francis

    Professor Shuichi Yamamoto

  77. Mutual Diffusion Coefficient of Aqueous Sugar Solutions.

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, January 1993, Taylor & Francis

    Professor Shuichi Yamamoto

  78. Drying of enzymes: enzyme retention during drying of a single droplet

    Article • Chemical Engineering Science, January 1992, Elsevier

    Professor Shuichi Yamamoto

  79. Stepwise elution chromatography as a method for both purification and concentration of proteins

    Article • Chemical Engineering Science, January 1992, Elsevier

    Professor Shuichi Yamamoto

  80. Calculation Method of Mutual Diffusion Coefficient in the Regular Regime of Desorption Process in Polymer Film Based on Approximation of the Power Function for Concentration Dependence of the Diffusion Coefficient.

    Article • KAGAKU KOGAKU RONBUNSHU, January 1991, Society of Chemical Engineers, Japan

    Professor Shuichi Yamamoto

  81. Calculation of concentration-dependent mutual diffusion coefficient in desorption of film.

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, January 1990, Taylor & Francis

    Professor Shuichi Yamamoto

  82. Adsorption chromatography of proteins: Determination of optimum conditions

    Article • AIChE Journal, September 1987, Wiley

    Professor Shuichi Yamamoto

  83. Factors affecting the relationship between the plate height and the linear mobile phase velocity in gel filtration chromatography of proteins

    Article • Journal of Chromatography A, January 1987, Elsevier

    Professor Shuichi Yamamoto

  84. Resolution of proteins in linear gradient elution ion-exchange and hydrophobic interaction chromatography

    Article • Journal of Chromatography A, January 1987, Elsevier

    Professor Shuichi Yamamoto

  85. Scaling up of medium-performance gel filtration chromatography of proteins.

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, January 1986, Taylor & Francis

    Professor Shuichi Yamamoto

  86. Drying of a drop of polymer solution of PAN (polyacrylonitrile)-DMF (dimethylformamide) system.

    Article • JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, January 1984, Taylor & Francis

    Professor Shuichi Yamamoto

  87. Ion exchange chromatography of proteins—prediction of elution curves and operating conditions. I. Theoretical considerations

    Article • Biotechnology and Bioengineering, June 1983, Wiley

    Professor Shuichi Yamamoto

  88. Mutual Diffusion CoeMcient of PAN-DMF System

    Article • KAGAKU KOGAKU RONBUNSHU, January 1983, Society of Chemical Engineers, Japan

    Professor Shuichi Yamamoto

  89. Operational Conditions for Desalting by Gel Chromatography

    Article • Agricultural and Biological Chemistry, December 1979, Oxford University Press (OUP)

    Professor Shuichi Yamamoto

  90. Analysis of dispersion mechanism in gel chromatography. V. Operational conditions for desalting by gel chromatography.

    Article • Agricultural and Biological Chemistry, January 1979, Oxford University Press (OUP)

    Professor Shuichi Yamamoto

  91. Analysis of dispersion mechanism in gel chromatography. IV. Operational conditions for gel chromatography - Prediction of elution curves.

    Article • Agricultural and Biological Chemistry, January 1979, Oxford University Press (OUP)

    Professor Shuichi Yamamoto

  92. Effect of Particle Size Distribution on Column Efficiency in Gel Chromatography

    Article • Agricultural and Biological Chemistry, October 1978, Oxford University Press (OUP)

    Professor Shuichi Yamamoto

  93. Effect of particle size distribution on column efficiency in gel chromatography.

    Article • Agricultural and Biological Chemistry, January 1978, Oxford University Press (OUP)

    Professor Shuichi Yamamoto

  94. Analysis of Dispersion Mechanism in Gel Chromatography

    Article • Agricultural and Biological Chemistry, August 1977, Oxford University Press (OUP)

    Professor Shuichi Yamamoto