What is it about?

This work describes the scale up of the production of astin C by the fungal endophyte Cyanodermella asteris.

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Why is it important?

Cyanodermella asteris is a fungal endophyte recently isolated from the medicinal plant Aster tataricus. C.asteris produces astin C, a cyclic pentapeptide with anticancer and anti-inflammatory properties. In this work we show that the production of astin C can be improved by using immobilized cell culture conditions.

Perspectives

The immobilized cell-culture conditions improve the production of astin C and enable a facilitate recovery and purification of the secondary metabolite. For future large scale production, the exclusive growth on the support will result in a significant decrease of downstream processing costs.

Professor Willem J.H. van Berkel
Wageningen University

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This page is a summary of: Astin C production by the endophytic fungus Cyanodermella asteris in planktonic and immobilized culture conditions, Biotechnology Journal, June 2019, Wiley, DOI: 10.1002/biot.201800624.
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