What is it about?
Weeds are the main rivals of cultivated plants for resources, such as water, light, nutrients and space. The consequence of this competition translates to a loss in agricultural production. A series of phthalides were synthesized and evaluated in seeds of plants. In silico study was carried out to identify the enzyme target of the most active compounds.
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Why is it important?
Compounds 15a, and 15b presented superior activity than the commercial herbicide (S)-metolachlor in the assays with Cucumis sativus, and Allium cepa. cepa. The in silico study provides strong evidence that the most active compounds bind to strigolactones esterases D14 through the same binding site of (5R)-5-hydroxy-3-methylfuran-2(5H)-one (H3M), which is one of the strigolactones (SLs) cleavage products.
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This page is a summary of: Herbicidal activity of isobenzofuranones and
identification of their enzyme target, Pest Management Science, May 2019, Wiley,
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