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A facile synthesis of 1,4-dihydroquinazolines from 2-aminobenzyl amine and carbon disulfide via dithiocarbamate performed at room temperature is reported. Corresponding S-alkyl quinazoline derivatives were obtained from 1,4-dihydroquinazolines in one-pot reactions under the palladium reagents after addition of alkyl halides.
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This page is a summary of: Tandem One Pot and Efficient Method for the Palladium-Reagent-Catalyzed Cross-Coupling of Quinazoline Thiols, Journal of Heterocyclic Chemistry, June 2015, Wiley, DOI: 10.1002/jhet.2310.
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