All Stories

  1. Enhancing Pharmacokinetics and Pharmacodynamics of Rosuvastatin Calcium through the Development and Optimization of Fast-Dissolving Films

    Article • Pharmaceutics, November 2023, MDPI AG

    Professor Khalid Mohamed El-Say

  2. Enhancing Ezetimibe Anticancer Activity Through Development of Drug Nano-Micelles Formulations: A Promising Strategy Supported by Molecular Docking

    Article • International Journal of Nanomedicine, November 2023, Taylor & Francis

    Professor Khalid Mohamed El-Say

  3. Incorporation of Perillyl Alcohol into Lipid-Based Nanocarriers Enhances the Antiproliferative Activity in Malignant Glioma Cells

    Article • Biomedicines, October 2023, MDPI AG

    Professor Khalid Mohamed El-Say

  4. Exploring the Enhanced Antiproliferative Activity of Turmeric Oil and 6-Mercaptopurine in a Combined Nano-Particulate System Formulation

    Article • Pharmaceutics, July 2023, MDPI AG

    Professor Khalid Mohamed El-Say

  5. Incorporating valsartan in sesame oil enriched self-nanoemulsifying system-loaded liquisolid tablets to improve its bioavailability

    Article • International Journal of Pharmaceutics, May 2023, Elsevier

    Professor Khalid Mohamed El-Say

  6. Correction: Incorporating sodium deoxycholate endorsed the buccal administration of avanafil to heighten the bioavailability and duration of action

    Article • Drug Delivery and Translational Research, April 2023, Springer Science + Business Media

    Professor Khalid Mohamed El-Say

  7. Incorporating sodium deoxycholate endorsed the buccal administration of avanafil to heighten the bioavailability and duration of action

    Article • Drug Delivery and Translational Research, February 2023, Springer Science + Business Media

    Professor Khalid Mohamed El-Say

  8. Enhancing the Antifungal Activity and Ophthalmic Transport of Fluconazole from PEGylated Polycaprolactone Loaded Nanoparticles

    Article • Polymers, December 2022, MDPI AG

    Professor Khalid Mohamed El-Say

  9. Tailoring Apixaban in Nanostructured Lipid Carrier Enhancing Its Oral Bioavailability and Anticoagulant Activity

    Article • Pharmaceutics, December 2022, MDPI AG

    Professor Khalid Mohamed El-Say

  10. Influences of Glimepiride Self-Nanoemulsifying Drug Delivery System Loaded Liquisolid Tablets on the Hypoglycemic Activity and Pancreatic Histopathological Changes in Streptozotocin-Induced Hyperglycemic Rats

    Article • Nanomaterials, November 2022, MDPI AG

    Professor Khalid Mohamed El-Say

  11. Effect of nanovesicular surface-functionalization via chitosan and/or PEGylation on cytotoxicity of tamoxifen in induced-breast cancer model

    Article • Life Sciences, October 2022, Elsevier

    Professor Khalid Mohamed El-Say

  12. Pairing 3D-Printing with Nanotechnology to Manage Metabolic Syndrome

    Article • International Journal of Nanomedicine, April 2022, Taylor & Francis

    Professor Khalid Mohamed El-Say

  13. Preclinical activity of fluvastatin‐loaded self‐nanoemulsifying delivery system against breast cancer models: Emphasis on apoptosis

    Article • Journal of Cellular Biochemistry, March 2022, Wiley

    Professor Khalid Mohamed El-Say

  14. Reexamining Povarov Reaction’s Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics

    Article • Heteroatom Chemistry, February 2022, Hindawi Publishing Corporation

    Professor Khalid Mohamed El-Say

  15. Does the technical methodology influence the quality attributes and the potential of skin permeation of Luliconazole loaded transethosomes?

    Article • Journal of Drug Delivery Science and Technology, February 2022, Elsevier

    Professor Khalid Mohamed El-Say

  16. Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization

    Article • Pharmaceuticals, January 2022, MDPI AG

    Professor Khalid Mohamed El-Say

  17. Transdermal Film Loaded with Avanafil Ultra-deformable Nanovesicles to Enhance its Percutaneous Absorption and Bioavailability

    Article • AAPS PharmSciTech, January 2022, Springer Science + Business Media

    Professor Khalid Mohamed El-Say

  18. Sublingual Route of Drug Delivery

    Article • January 2022, Springer Science + Business Media

    Professor Khalid Mohamed El-Say

  19. Buccal Route of Drug Delivery

    Article • January 2022, Springer Science + Business Media

    Professor Khalid Mohamed El-Say

  20. Cholesterol-Based Nanovesicles Enhance the In Vitro Cytotoxicity, Ex Vivo Intestinal Absorption, and In Vivo Bioavailability of Flutamide

    Article • Pharmaceutics, October 2021, MDPI AG

    Professor Khalid Mohamed El-Say

  21. Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine

    Article • Pharmaceutics, October 2021, MDPI AG

    Professor Khalid Mohamed El-Say

  22. Oleic acid–reinforced PEGylated polymethacrylate transdermal film with enhanced antidyslipidemic activity and bioavailability of atorvastatin: A mechanistic ex-vivo/in-vivo analysis

    Article • International Journal of Pharmaceutics, October 2021, Elsevier

    Professor Khalid Mohamed El-Say

  23. Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease

    Article • Pharmaceutics, July 2021, MDPI AG

    Professor Khalid Mohamed El-Say

  24. Investigating the Potential of Transdermal Delivery of Avanafil Using Vitamin E-TPGS Based Mixed Micelles Loaded Films

    Article • Pharmaceutics, May 2021, MDPI AG

    Professor Khalid Mohamed El-Say

  25. Buccal Route of Drug Delivery

    Article • January 2021, Springer Science + Business Media

    Professor Khalid Mohamed El-Say

  26. Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction

    Article • Pharmaceutics, December 2020, MDPI AG

    Professor Khalid Mohamed El-Say

  27. Rosuvastatin lyophilized tablets loaded with flexible chitosomes for improved drug bioavailability, anti-hyperlipidemic and anti-oxidant activity

    Article • International Journal of Pharmaceutics, October 2020, Elsevier

    Professor Khalid Mohamed El-Say

  28. Development of Pomegranate Extract-Loaded Solid Lipid Nanoparticles: Quality by Design Approach to Screen the Variables Affecting the Quality Attributes and Characterization

    Article • ACS Omega, August 2020, American Chemical Society (ACS)

    Professor Khalid Mohamed El-Say

  29. Enhancing the Hypolipidemic Effect of Simvastatin in Poloxamer-Induced Hyperlipidemic Rats via Liquisolid Approach: Pharmacokinetic and Pharmacodynamic Evaluation

    Article • AAPS PharmSciTech, August 2020, Springer Science + Business Media

    Professor Khalid Mohamed El-Say

  30. Improved Transmucosal Delivery of Glimepiride via Unidirectional Release Buccal Film Loaded With Vitamin E TPGS-Based Nanocarrier

    Article • Dose-Response, July 2020, SAGE Publications

    Professor Osama A A Ahmed, Professor Khalid Mohamed El-Say

  31. Regulation of Autophagy Progress via Lysosomal Depletion by Fluvastatin Nanoparticle Treatment in Breast Cancer Cells

    Article • ACS Omega, June 2020, American Chemical Society (ACS)

    Professor Khalid Mohamed El-Say

  32. Investigating the Potential of Transmucosal Delivery of Febuxostat from Oral Lyophilized Tablets Loaded with a Self-Nanoemulsifying Delivery System

    Article • Pharmaceutics, June 2020, MDPI AG

    Professor Khalid Mohamed El-Say

  33. The promising expedition of the delivery systems for monoclonal antibodies

    Article • January 2020, Elsevier

    Professor Khalid Mohamed El-Say

  34. An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats

    Article • Drug Design Development and Therapy, December 2019, Taylor & Francis

    Dr Tarek A Ahmed, Professor Khalid El-Say, Professor Khalid Mohamed El-Say

  35. Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation

    Article • International Journal of Nanomedicine, September 2019, Taylor & Francis

    Professor Osama A A Ahmed, Professor Khalid El-Say, Professor Khalid Mohamed El-Say

  36. Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel

    Article • International Journal of Nanomedicine, July 2019, Dove Medical Press

    Dr Tarek A Ahmed, Professor Osama A A Ahmed, Professor Khalid Mohamed El-Say

  37. Chitosan-TPP nanoparticles stabilized by poloxamer for controlling the release and enhancing the bioavailability of doxazosin mesylate: in vitro, and in vivo evaluation

    Article • Drug Development and Industrial Pharmacy, March 2019, Taylor & Francis

    Professor Khalid El-Say, Professor Khalid Mohamed El-Say

  38. Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

    Article • Pharmaceutics, January 2019, MDPI AG

    Professor Khalid Mohamed El-Say

  39. Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

    Article • December 2018, MDPI AG

    Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  40. Optimized vinpocetine-loaded vitamin E D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: in vitro and ex vivo studies

    Article • International Journal of Nanomedicine, December 2018, Dove Medical Press

    Professor Osama A A Ahmed, Dr Bader M Aljaeid, Professor Khalid El-Say, Dr Tarek A Ahmed, Professor Khalid Mohamed El-Say

  41. Stimuli-Responsive drug delivery systems to solid tumor

    Article • ACS Nano, October 2018, American Chemical Society (ACS)

    Professor Khalid Mohamed El-Say

  42. Optimization of carvedilol solid lipid nanoparticles: An approach to control the release and enhance the oral bioavailability on rabbits

    Article • PLoS ONE, August 2018, PLOS

    Professor Khalid Mohamed El-Say

  43. Development of a fluvastatin-loaded self-nanoemulsifying system to maximize therapeutic efficacy in human colorectal carcinoma cells

    Article • Journal of Drug Delivery Science and Technology, August 2018, Elsevier

    Professor Khalid Mohamed El-Say

  44. Quality by design approach to screen the formulation and process variables influencing the characteristics of carvedilol solid lipid nanoparticles

    Article • Journal of Drug Delivery Science and Technology, June 2018, Elsevier

    Professor Khalid Mohamed El-Say

  45. Evaluate the anticancer activity of pomegranate extract solid lipid nanopartilces.

    Article • International Journal of Nanomedicine, March 2018, Dove Medical Press

    Professor Khalid Mohamed El-Say, Dalia Attia, Noha Badawi

  46. Enhancing the Therapeutic Efficacy of Tamoxifen Citrate Loaded Span-Based Nano-Vesicles on Human Breast Adenocarcinoma Cells

    Article • AAPS PharmSciTech, February 2018, American Association of Pharmaceutical Scientists (AAPS)

    Professor Khalid Mohamed El-Say

  47. Sterile dosage forms loaded nanosystems for parenteral, nasal, pulmonary and ocular administration

    Article • January 2018, Elsevier

    Professor Khalid Mohamed El-Say

  48. Development of optimized self-nanoemulsifying lyophilized tablets (SNELTs) to improve finasteride clinical pharmacokinetic behavior

    Article • Drug Development and Industrial Pharmacy, November 2017, Taylor & Francis

    Professor Khalid Mohamed El-Say

  49. A PLGA-reinforced PEG in situ gel formulation for improved sustainability of hypoglycaemic activity of glimepiride in streptozotocin-induced diabetic rats

    Article • Scientific Reports, November 2017, Nature

    Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  50. Self-Nanoemulsifying Lyophilized Tablets for Flash Oral Transmucosal Delivery of Vitamin K: Development and Clinical Evaluation

    Article • Journal of Pharmaceutical Sciences, September 2017, Elsevier

    Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  51. Polymeric nanoparticles: Promising platform for drug delivery

    Article • International Journal of Pharmaceutics, August 2017, Elsevier

    Professor Khalid El-Say, Professor Khalid Mohamed El-Say

  52. Maximizing the Therapeutic Efficacy of Imatinib Mesylate–Loaded Niosomes on Human Colon Adenocarcinoma Using Box-Behnken Design

    Article • Journal of Pharmaceutical Sciences, January 2017, Elsevier

    Professor Khalid Mohamed El-Say

  53. Transdermal film-loaded finasteride microplates to enhance drug skin permeation: Two-step optimization study

    Article • European Journal of Pharmaceutical Sciences, June 2016, Elsevier

    Professor Khalid Mohamed El-Say

  54. Development and optimization of fluoxetine orally disintegrating tablets using Box-Behnken design

    Article • Tropical Journal of Pharmaceutical Research, May 2016, African Journals Online (AJOL)

    Professor Khalid Mohamed El-Say

  55. Transdermal glimepiride delivery system based on optimized ethosomal nano-vesicles: Preparation, characterization, in vitro , ex vivo and clinical evaluation

    Article • International Journal of Pharmaceutics, March 2016, Elsevier

    Dr Bader M Aljaeid, Professor Khalid Mohamed El-Say

  56. Maximizing the encapsulation efficiency and the bioavailability of controlled-release cetirizine microspheres using Draper–Lin small composite design

    Article • Drug Design Development and Therapy, February 2016, Dove Medical Press

    Professor Khalid El-Say, Professor Khalid Mohamed El-Say

  57. Glycosylated Sertraline-Loaded Liposomes for Brain Targeting: QbD Study of Formulation Variabilities and Brain Transport

    Article • AAPS PharmSciTech, January 2016, American Association of Pharmaceutical Scientists (AAPS)

    Dr Bader M Aljaeid, Professor Khalid Mohamed El-Say

  58. Depot injectable atorvastatin biodegradable in situ gel: development, optimization, in vitro, and in vivo evaluation

    Article • Drug Design Development and Therapy, January 2016, Dove Medical Press

    Dr Tarek A Ahmed, Professor Khalid El-Say, Professor Khalid Mohamed El-Say

  59. Optimized gastroretentive floating carvedilol tablets: an approach for prolonged gastric residence time and enhanced absorption

    Article • Journal of Applied Pharmaceutical Science, January 2016, Journal of Applied Pharmaceutical Science

    Professor Khalid Mohamed El-Say

  60. Matrix-type transdermal films to enhance simvastatin ex vivo skin permeability

    Article • Pharmaceutical Development and Technology, October 2015, Taylor & Francis

    Professor Khalid Mohamed El-Say, Dr Bader M Aljaeid, Professor Osama A A Ahmed

  61. nanotechnology and drug delivery

    Article • International Journal of Nanomedicine, June 2015, Dove Medical Press

    Dr Tarek A Ahmed, Professor Khalid Mohamed El-Say, Dr Bader M Aljaeid, Professor Khalid El-Say

  62. Diacerein niosomal gel for topical delivery: development,in vitroandin vivoassessment

    Article • Journal of Liposome Research, April 2015, Taylor & Francis

    Professor Khalid Mohamed El-Say

  63. Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits

    Article • Drug Design Development and Therapy, March 2015, Taylor & Francis

    Dr Osama A Ahmed, Professor Khalid Mohamed El-Say, Professor Khalid El-Say, Professor Osama A A Ahmed

  64. Risperidone oral disintegrating mini-tablets: A robust-product for pediatrics

    Article • Acta Pharmaceutica, January 2015, De Gruyter

    Dr Bader M Aljaeid, Professor Khalid Mohamed El-Say

  65. Development of alginate-reinforced chitosan nanoparticles utilizing W/O nanoemulsification/internal crosslinking technique for transdermal delivery of rabeprazole

    Article • Life Sciences, August 2014, Elsevier

    Professor Khalid Mohamed El-Say

  66. Enhanced permeation parameters of optimized nanostructured simvastatin transdermal films:ex vivoandin vivoevaluation

    Article • Pharmaceutical Development and Technology, July 2014, Taylor & Francis

    Dr Shaimaa M Badr-Eldin, Dr usama ahmed fahmy, Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  67. Optimized sildenafil citrate fast orodissolvable film: a promising formula for overcoming the barriers hindering erectile dysfunction treatment

    Article • Drug Delivery, May 2014, Taylor & Francis

    Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  68. Statistical optimization of controlled release microspheres containing cetirizine hydrochloride as a model for water soluble drugs

    Article • Pharmaceutical Development and Technology, May 2014, Taylor & Francis

    Dr usama ahmed fahmy, Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  69. Optimization of self-nanoemulsifying systems for the enhancement ofin vivohypoglycemic efficacy of glimepiride transdermal patches

    Article • Expert Opinion on Drug Delivery, April 2014, Informa Healthcare

    Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  70. Design and Optimization of Self-Nanoemulsifying Delivery System to Enhance Quercetin Hepatoprotective Activity in Paracetamol-Induced Hepatotoxicity

    Article • Journal of Pharmaceutical Sciences, February 2014, Elsevier

    Dr Tarek A Ahmed, Dr Shaimaa M Badr-Eldin, Professor Khalid Mohamed El-Say, Professor Osama A A Ahmed

  71. Antihyperlipidemic effect of ambrex, a polyherbal formulation against experimentally induced hypercholesterolemia in rats

    Article • African Journal of Pharmacy and Pharmacology, July 2013, Academic Journals

    Professor Khalid Mohamed El-Say

  72. Miconazole Nitrate Oral Disintegrating Tablets: In Vivo Performance and Stability Study

    Article • AAPS PharmSciTech, May 2012, American Association of Pharmaceutical Scientists (AAPS)

    Professor Khalid Mohamed El-Say