All Stories

  1. Diverse MicroRNAs‐mRNA networks regulate the priming phase of mouse liver regeneration and of direct hyperplasia

    Article • Cell Proliferation, February 2022, Wiley

    Professor amedeo columbano

  2. TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD

    Article • International Journal of Molecular Sciences, December 2021, MDPI AG

    Professor amedeo columbano

  3. Animal Models: A Useful Tool to Unveil Metabolic Changes in Hepatocellular Carcinoma

    Article • Cancers, November 2020, MDPI AG

    Professor amedeo columbano

  4. Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases

    Article • Cancers, October 2020, MDPI AG

    Professor amedeo columbano

  5. Distinct Mechanisms Are Responsible for Nrf2-Keap1 Pathway Activation at Different Stages of Rat Hepatocarcinogenesis

    Article • Cancers, August 2020, MDPI AG

    Professor amedeo columbano

  6. Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?

    Article • Frontiers in Oncology, April 2020, Frontiers

    Professor amedeo columbano

  7. Potential role of two novel agonists of thyroid hormone receptor‐β on liver regeneration

    Article • Cell Proliferation, April 2020, Wiley

    Professor amedeo columbano

  8. Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

    Article • European Journal of Medicinal Chemistry, February 2020, Elsevier

    Professor amedeo columbano

  9. Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming

    Article • Journal of Hepatology, January 2020, Elsevier

    Professor amedeo columbano

  10. Clustered protocadherins methylation alterations in cancer

    Article • Clinical Epigenetics, July 2019, Springer Science + Business Media

    Professor amedeo columbano

  11. Yes-associated protein promotes early hepatocyte cell cycle progression in regenerating liver after tissue loss

    Article • FASEB BioAdvances, November 2018, Federation of American Societies For Experimental Biology (FASEB)

    Professor amedeo columbano

  12. High Frequency of β-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist

    Article • American Journal Of Pathology, September 2018, Elsevier

    Professor amedeo columbano

  13. miR‐205 mediates adaptive resistance to MET inhibition via ERRFI1 targeting and raised EGFR signaling

    Article • EMBO Molecular Medicine, July 2018, EMBO

    Professor amedeo columbano

  14. Thyroid Hormones, Thyromimetics and Their Metabolites in the Treatment of Liver Disease

    Article • Frontiers in Endocrinology, July 2018, Frontiers

    Professor amedeo columbano

  15. Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis

    Article • Journal of Hepatology, June 2018, Elsevier

    Professor amedeo columbano

  16. Colorectal cancer early methylation alterations affect the crosstalk between cell and surrounding environment, tracing a biomarker signature specific for this tumor

    Article • International Journal of Cancer, April 2018, Wiley

    Professor amedeo columbano

  17. Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury

    Article • Cell Death Discovery, December 2017, Springer Science + Business Media

    Professor amedeo columbano

  18. GC-1: A Thyromimetic With Multiple Therapeutic Applications in Liver Disease

    Article • Gene Expression, November 2017, Cognizant Communication Corporation

    Professor amedeo columbano

  19. Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin–Driven Hepatocellular Cancer

    Article • American Journal Of Pathology, November 2017, Elsevier

    Professor amedeo columbano

  20. Estimation of a significance threshold for epigenome-wide association studies

    Article • Genetic Epidemiology, October 2017, Wiley

    Professor amedeo columbano

  21. The Thyromimetic KB2115 (Eprotirome) Induces Rat Hepatocyte Proliferation

    Article • Gene Expression, July 2017, Cognizant Communication Corporation

    Professor amedeo columbano

  22. A long term, non-tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis

    Article • Oncotarget, February 2017, Impact Journals, LLC

    Professor amedeo columbano

  23. Inducing liver regeneration in transplantation setting

    Article • Gene Expression, August 2016, Cognizant Communication Corporation

    Dr. Satdarshan P Monga, Professor amedeo columbano

  24. Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss

    Article • Journal of Hepatology, July 2016, Elsevier

    Professor amedeo columbano

  25. The Dual Roles of NRF2 in Cancer

    Article • Trends in Molecular Medicine, July 2016, Elsevier

    Professor amedeo columbano

  26. T3/TRs axis in hepatocellular carcinoma: new concepts for an old pair

    Article • Endocrine Related Cancer, June 2016, Bioscientifica

    Professor amedeo columbano, Dr. Andrea Perra

  27. Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

    Article • Oncotarget, April 2016, Impact Journals, LLC

    Dr. Andrea Perra, Professor amedeo columbano

  28. The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival

    Article • Journal of Hepatology, April 2016, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  29. Induction of autophagy promotes the growth of early preneoplastic rat liver nodules

    Article • Oncotarget, December 2015, Impact Journals, LLC

    Professor amedeo columbano

  30. Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis

    Article • Oncotarget, October 2015, Impact Journals, LLC

    Professor amedeo columbano

  31. Reply to: “YAP in tumorigenesis: Friend or foe?”

    Article • Journal of Hepatology, June 2015, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  32. Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis

    Article • Hepatology, April 2015, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  33. Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats

    Article • Hepatology, November 2014, Wiley

    Professor amedeo columbano, Dr. Andrea Perra

  34. YAP activation is an early event and a potential therapeutic target in liver cancer development

    Article • Journal of Hepatology, November 2014, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  35. Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration

    Article • Hepatology, July 2014, Wolters Kluwer Health

    Professor amedeo columbano

  36. Tri-iodothyronine induces hepatocyte proliferation by protein kinase a-dependent β-catenin activation in rodents

    Article • Hepatology, April 2014, Wiley

    Professor amedeo columbano

  37. Met as a therapeutic target in HCC: Facts and hopes

    Article • Journal of Hepatology, February 2014, Elsevier

    Professor amedeo columbano

  38. MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)

    Article • Hepatology, November 2013, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  39. MicroRNAs: New tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?

    Article • Hepatology, December 2012, Wiley

    Professor amedeo columbano

  40. Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression

    Article • Oncogene, January 2012, Nature

    Dr. Andrea Perra, Professor amedeo columbano, Full Professor in Experimental Biology Giuseppina De Petro

  41. MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon Cancer

    Article • Clinical Cancer Research, December 2011, American Association for Cancer Research (AACR)

    Professor amedeo columbano

  42. Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice

    Article • Journal of Clinical Investigation, November 2011, American Society for Clinical Investigation

    Professor amedeo columbano

  43. Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3

    Article • Journal of Hepatology, November 2011, Elsevier

    Professor amedeo columbano

  44. Reply

    Article • Hepatology, August 2011, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  45. Proteomic Characterization of Early Changes Induced by Triiodothyronine in Rat Liver

    Article • Journal of Proteome Research, July 2011, American Chemical Society (ACS)

    Professor amedeo columbano

  46. Gender-Specific Interplay of Signaling through β-Catenin and CAR in the Regulation of Xenobiotic-Induced Hepatocyte Proliferation

    Article • Toxicological Sciences, June 2011, Oxford University Press (OUP)

    Professor amedeo columbano

  47. Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice

    Article • Hepatology, May 2011, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  48. Hepatocyte Growth, Proliferation and Experimental Carcinogenesis

    Article • November 2010, Springer Science + Business Media

    Professor amedeo columbano

  49. TRβ is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells

    Article • Journal of Hepatology, October 2010, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  50. The TR -selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine

    Article • Journal of Endocrinology, April 2010, Bioscientifica

    Professor amedeo columbano

  51. Progenitor-derived hepatocellular carcinoma model in the rat

    Article • Hepatology, December 2009, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  52. Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype

    Article • Hepatology, November 2008, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  53. Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration

    Article • Cell Proliferation, June 2008, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  54. Thyroid hormone (T3) and TR  agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats

    Article • The FASEB Journal, April 2008, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Andrea Perra, Professor amedeo columbano

  55. Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation

    Article • Laboratory Investigation, February 2008, Nature

    Dr. Andrea Perra, Professor amedeo columbano

  56.  -lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model

    Article • Carcinogenesis, November 2007, Oxford University Press (OUP)

    Dr. Andrea Perra, Professor amedeo columbano

  57. Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene

    Article • Cancer Letters, June 2007, Elsevier

    Professor amedeo columbano

  58. Increased ROS generation and p53 activation in α-lipoic acid-induced apoptosis of hepatoma cells

    Article • APOPTOSIS, November 2006, Springer Science + Business Media

    Professor amedeo columbano

  59. The Thyroid Hormone Receptor-β Agonist GC-1 Induces Cell Proliferation in Rat Liver and Pancreas

    Article • Endocrinology, July 2006, Endocrine Society

    Professor amedeo columbano

  60. Thyroid hormone induces cyclin D1 nuclear translocation and DNA synthesis in adult rat cardiomyocytes

    Article • The FASEB Journal, January 2006, Federation of American Societies For Experimental Biology (FASEB)

    Professor amedeo columbano

  61. Induction of pancreatic acinar cell proliferation by thyroid hormone

    Article • Journal of Endocrinology, June 2005, Bioscientifica

    Professor amedeo columbano

  62. Gadd45β is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia

    Article • Hepatology, January 2005, Wiley

    Professor amedeo columbano

  63. Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP

    Article • Hepatology, October 2004, Wiley

    Professor amedeo columbano

  64. Induction of hepatocyte proliferation by retinoic acid

    Article • Carcinogenesis, June 2004, Oxford University Press (OUP)

    Professor amedeo columbano

  65. The peroxisome proliferator BR931 kills FaO cells by p53-dependent apoptosis

    Article • Life Sciences, June 2004, Elsevier

    Professor amedeo columbano

  66. Aging does not reduce the hepatocyte proliferative response of mice to the primary mitogen TCPOBOP

    Article • Hepatology, January 2004, Wiley

    Professor amedeo columbano

  67. A common set of immediate-early response genes in liver regeneration and hyperplasia

    Article • Hepatology, August 2003, Wiley

    Professor amedeo columbano

  68. Different Effects of the Liver Mitogens Triiodo-Thyronine and Ciprofibrate on the Development of Rat Hepatocellular Carcinoma

    Article • Toxicologic Pathology, January 2003, SAGE Publications

    Dr. Andrea Perra, Professor amedeo columbano

  69. Mitogenesis by ligands of nuclear receptors: an attractive model for the study of the molecular mechanisms implicated in liver growth

    Article • Cell Death and Differentiation, January 2003, Springer Science + Business Media

    Professor amedeo columbano

  70. Loss of cyclin D1 does not inhibit the proliferative response of mouse liver to mitogenic stimuli

    Article • Hepatology, November 2002, Wiley

    Professor amedeo columbano

  71. Peroxisome proliferator–activated receptor-α−/− mice show enhanced hepatocyte proliferation in response to the hepatomitogen 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene, a ligand of constitutive androstane receptor

    Article • Hepatology, August 2001, Wiley

    Professor amedeo columbano

  72. Regulatory effects of senescence marker protein 30 on the proliferation of hepatocytes

    Article • Pathology International, July 2001, Wiley

    Dr Akihito Ishigami, Professor amedeo columbano

  73. Cyclin D1 is an early target in hepatocyte proliferation induced by thyroid hormone (T3)

    Article • The FASEB Journal, April 2001, Federation of American Societies For Experimental Biology (FASEB)

    Professor amedeo columbano

  74. Ciprofibrate and triiodothyronine do not suppress in vivo induction of placental glutathione S-transferase expression in rat hepatocytes

    Article • Cancer Letters, April 2000, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  75. Early Increase in Cyclin-D1 Expression and Accelerated Entry of Mouse Hepatocytes into S Phase after Administration of the Mitogen 1,4-Bis[2-(3,5-Dichloropyridyloxy)] Benzene

    Article • American Journal Of Pathology, January 2000, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  76. Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-?B and AP-1 or with expression of tumor necrosis factor ?

    Article • Hepatology, March 1997, Wiley

    Professor amedeo columbano

  77. Increased expression of c-fos, c-jun and LRF-1 is not required for in vivo priming of hepatocytes by the mitogen TCPOBOP

    Article • Oncogene, January 1997, Nature

    Professor amedeo columbano

  78. Qualitative and quantitative analysis of AgNOR proteins in chemically induced rat liver carcinogenesis

    Article • Hepatology, November 1996, Wiley

    Professor amedeo columbano

  79. Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor alpha

    Article • Hepatology, June 1996, Wiley

    Professor amedeo columbano

  80. 9-Cis retinoic acid is a direct hepatocyte mitogen in rats

    Article • Life Sciences, February 1996, Elsevier

    Professor amedeo columbano

  81. Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis

    Article • Carcinogenesis, January 1996, Oxford University Press (OUP)

    Professor amedeo columbano

  82. Genetic mapping and expression analysis of the murine DNA ligase I gene

    Article • Molecular Carcinogenesis, October 1995, Wiley

    Professor amedeo columbano

  83. Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo

    Article • Journal of Cellular Biochemistry, June 1995, Wiley

    Professor amedeo columbano

  84. Genotoxic and non-genotoxic activities of 2,4- and 2,6-diaminotoluene, as evaluated in Fischer-344 rat liver

    Article • Toxicology, May 1995, Elsevier

    Professor amedeo columbano

  85. Different Effects of Regenerative and Direct Mitogenic Stimuli on the Growth of Initiated Cells in the Resistant Hepatocyte Model

    Article • Japanese Journal of Cancer Research, May 1993, Wiley

    Professor amedeo columbano

  86. Involvement of DNA polymerase β in proliferation of rat liver induced by lead nitrate or partial hepatectomy

    Article • FEBS Letters, September 1992, Wiley

    Professor amedeo columbano

  87. Expression of the gene for poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues and in proliferating cells

    Article • January 1992, Springer Science + Business Media

    Professor amedeo columbano

  88. Stimulation of DNA synthesis by rat plasma following in vivo treatment with three liver mitogens

    Article • Cancer Letters, January 1992, Elsevier

    Professor amedeo columbano

  89. Regulation of poly(ADP-ribose) polymerase mRNA levels during compensatory and mitogen-induced growth of rat liver

    Article • Archives of Biochemistry and Biophysics, June 1990, Elsevier

    Professor amedeo columbano

  90. Studies on the kinetics of expression of cell cycle dependent proto-oncogenes during mitogen-induced liver cell proliferation

    Article • Cancer Letters, September 1989, Elsevier

    Professor amedeo columbano

  91. Induction of rat liver glutathione transferase subunit 7 by lead nitrate

    Article • Cancer Letters, August 1989, Elsevier

    Professor amedeo columbano

  92. Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethylnitrosamine

    Article • Cancer Letters, September 1987, Elsevier

    Professor amedeo columbano

  93. Cell proliferation in rat kidney induced by 1,2-dibromoethane

    Article • Toxicology Letters, June 1987, Elsevier

    Professor amedeo columbano

  94. Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis

    Article • Carcinogenesis, January 1987, Oxford University Press (OUP)

    Professor amedeo columbano

  95. Hexose monophosphate shunt and cholesterogenesis in lead-induced kidney hyperplasia

    Article • Chemico-Biological Interactions, January 1987, Elsevier

    Professor amedeo columbano

  96. Lead nitrate induces certain biochemical properties characteristic of hepatocyte nodules

    Article • Carcinogenesis, January 1986, Oxford University Press (OUP)

    Professor amedeo columbano

  97. Enhancement of cholesterol synthesis and pentose phosphate pathway activity in proliferating hepatocyte nodules

    Article • Carcinogenesis, January 1985, Oxford University Press (OUP)

    Professor amedeo columbano

  98. Stimulation of DNA synthesis after a single administration of cadmium nitrate

    Article • Toxicology Letters, December 1984, Elsevier

    Professor amedeo columbano

  99. Stimulation of rat liver growth by a single administration of lead nitrate

    Article • Toxicology and Applied Pharmacology, September 1982, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  100. Dietary orotic acid, a new selective growth stimulus for carcinogen altered hepatocytes in rat☆

    Article • Cancer Letters, July 1982, Elsevier

    Professor amedeo columbano

  101. Requirement of cell proliferation for the induction of presumptive preneoplastic lesions in rat liver by a single dose of 1,2-dimethylhydrazine

    Article • Chemico-Biological Interactions, November 1980, Elsevier

    Professor amedeo columbano

  102. Susceptibility of dimethylnitrosamine induced O6-methylguanine containing regions in in vivo replicated, hybrid rat liver DNA towards S1 nuclease☆

    Article • Cancer Letters, October 1980, Elsevier

    Professor amedeo columbano

  103. In vivo replication of carcinogen-modified rat liver DNA: Increased susceptibility of 06-methylguanine compared to N-7-methylguanine in replicated DNA to S1-nuclease

    Article • Biochemical and Biophysical Research Communications, July 1980, Elsevier

    Professor amedeo columbano

  104. Differential effects of choline administration on liver microsomes of female and male rats

    Article • Experimental and Molecular Pathology, April 1978, Elsevier

    Professor amedeo columbano

  105. Effect of choline administration on the toxicity of N-nitrosodimethylamine in female rats

    Article • Toxicology and Applied Pharmacology, December 1977, Elsevier

    Professor amedeo columbano