All Stories

  1. α2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons

    Article • Neuroscience, September 2016, Elsevier

    Dr. Andrea Perra

  2. Abstract 1009: Metabolic reprogramming discriminates aggressive vs. slowly growing preneoplastic lesions at early stages of HCC development

    Article • Cancer Research, July 2016, American Association for Cancer Research (AACR)

    Dr. Andrea Perra

  3. Reactivation of thyroid hormone receptors in fully developed rat hepatocellular carcinomas causes their regression and prevents lung metastasis

    Article • European Journal of Cancer, July 2016, Elsevier

    Dr. Andrea Perra

  4. T3/TRs axis in hepatocellular carcinoma: new concepts for an old pair

    Article • Endocrine Related Cancer, June 2016, Bioscientifica

    Professor amedeo columbano, Dr. Andrea Perra

  5. Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

    Article • Oncotarget, April 2016, Impact Journals, LLC

    Dr. Andrea Perra, Professor amedeo columbano

  6. The metabolic gene HAO2 is downregulated in hepatocellular carcinoma and predicts metastasis and poor survival

    Article • Journal of Hepatology, April 2016, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  7. Abstract A02: OXPHOS inhibition and pentose phosphate pathway induction are early events priming preneoplastic lesions toward HCC development

    Article • Molecular Cancer Research, January 2016, American Association for Cancer Research (AACR)

    Dr. Andrea Perra

  8. Analysis of NRF2-KEAP1 Pathway and Metabolic Reprogramming in Two Distinct Models of Rat Liver Proliferation

    Article • Journal of Hepatology, January 2016, Elsevier

    Dr. Andrea Perra

  9. Metabolic Reprogramming toward Awarburg Phenotype Characterizes Early Phases of Hepatic Carcinogenesis

    Article • Journal of Hepatology, January 2016, Elsevier

    Dr. Andrea Perra

  10. Reply to: “YAP in tumorigenesis: Friend or foe?”

    Article • Journal of Hepatology, June 2015, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  11. Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis

    Article • Hepatology, April 2015, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  12. P0306 : Impairment of autophagy in the early stages of hepatocarcinogenesis

    Article • Journal of Hepatology, April 2015, Elsevier

    Dr. Andrea Perra

  13. P0397 : Nrf2 mutations are an early and frequent event in the development of rat hepatocellular carcinoma

    Article • Journal of Hepatology, April 2015, Elsevier

    Dr. Andrea Perra

  14. P0317 : Down-regulation of Hao2 is associated with the onset and development of hepatocellular carcinoma in rodents

    Article • Journal of Hepatology, April 2015, Elsevier

    Dr. Andrea Perra

  15. Local hypothyroidism favors the progression of preneoplastic lesions to hepatocellular carcinoma in rats

    Article • Hepatology, November 2014, Wiley

    Professor amedeo columbano, Dr. Andrea Perra

  16. YAP activation is an early event and a potential therapeutic target in liver cancer development

    Article • Journal of Hepatology, November 2014, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  17. Abstract 1399: NRF2 mutations are frequent in early rat preneoplastic hepatic lesions and in human hepatocellular carcinomas positive for the stem/progenitor cell marker KRT-19

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Dr. Andrea Perra

  18. P59 YES-ASSOCIATED PROTEIN (YAP) IS REQUIRED FOR THE CLONAL EXPANSION OF PRENEOPLASTIC HEPATOCYTES AND OVAL CELL PROLIFERATION

    Article • Journal of Hepatology, April 2014, Elsevier

    Dr. Andrea Perra

  19. MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC)

    Article • Hepatology, November 2013, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  20. Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression

    Article • Oncogene, January 2012, Nature

    Dr. Andrea Perra, Professor amedeo columbano, Full Professor in Experimental Biology Giuseppina De Petro

  21. Reply

    Article • Hepatology, August 2011, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  22. Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice

    Article • Hepatology, May 2011, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  23. 216 MIR-100 IS DOWNREGULATED FROM EARLY STAGES OF HEPATOCARCINOGENESIS AND CORRELATES WITH OVEREXPRESSION OF ITS TARGET PLK1

    Article • Journal of Hepatology, March 2011, Elsevier

    Dr. Andrea Perra

  24. TRβ is the critical thyroid hormone receptor isoform in T3-induced proliferation of hepatocytes and pancreatic acinar cells

    Article • Journal of Hepatology, October 2010, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  25. Abstract 2173: Cytokeratin-19, a predictive marker and an early determinant of progenitor-derived hepatocellular carcinoma

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Dr. Andrea Perra

  26. Progenitor-derived hepatocellular carcinoma model in the rat

    Article • Hepatology, December 2009, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  27. Hepatic stellate cell: A star cell in the liver

    Article • The International Journal of Biochemistry & Cell Biology, August 2009, Elsevier

    Dr. Andrea Perra

  28. 535 THYROID HORMONE RECEPTOR LIGANDS INDUCE REGRESSION OF RAT PRENEOPLASTIC LIVER LESIONS CAUSING THEIR REVERSION TO A DIFFERENTIATED PHENOTYPE

    Article • Journal of Hepatology, April 2009, Elsevier

    Dr. Andrea Perra

  29. Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype

    Article • Hepatology, November 2008, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  30. Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration

    Article • Cell Proliferation, June 2008, Wiley

    Dr. Andrea Perra, Professor amedeo columbano

  31. Thyroid hormone (T3) and TR  agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats

    Article • The FASEB Journal, April 2008, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Andrea Perra, Professor amedeo columbano

  32. Potential utility of xenobiotic mitogens in the context of liver regeneration in the elderly and living-related transplantation

    Article • Laboratory Investigation, February 2008, Nature

    Dr. Andrea Perra, Professor amedeo columbano

  33. 961 THE SELECTIVE TR-BETA AGONIST, GC-1 AND TRIIODOTHYRONINE PREVENT AND REVERSE STEATOHEPATITIS INDUCED BY A CHOLINE-DEFICIENT DIET IN RATS

    Article • Journal of Hepatology, January 2008, Elsevier

    Dr. Andrea Perra

  34. 509 POTENTIAL UTILITY OF XENOBIOTIC MITOGENS IN THE CONTEXT OF LIVER REGENERATION IN THE ELDERLY AND LIVING-RELATED TRANSPLANTATION

    Article • Journal of Hepatology, January 2008, Elsevier

    Dr. Andrea Perra

  35.  -lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model

    Article • Carcinogenesis, November 2007, Oxford University Press (OUP)

    Dr. Andrea Perra, Professor amedeo columbano

  36. [372] ALPHA-LIPOIC ACID ENHANCES CHOLINE DEFICIENT DIET-INDUCED FATTY LIVER AND STEATOHEPATITIS, AND PROMOTES THE GROWTH OF PRENEOPLASTIC LESIONS IN RAT LIVER

    Article • Journal of Hepatology, April 2007, Elsevier

    Dr. Andrea Perra

  37. α-Lipoic acid promotes preneoplastic growth in rat liver

    Article • Seminars in Musculoskeletal Radiology, January 2007, Thieme Publishing Group

    Dr. Andrea Perra

  38. Different Effects of the Liver Mitogens Triiodo-Thyronine and Ciprofibrate on the Development of Rat Hepatocellular Carcinoma

    Article • Toxicologic Pathology, January 2003, SAGE Publications

    Dr. Andrea Perra

  39. Different Effects of the Liver Mitogens Triiodo-Thyronine and Ciprofibrate on the Development of Rat Hepatocellular Carcinoma

    Article • Toxicologic Pathology, January 2003, SAGE Publications

    Dr. Andrea Perra, Professor amedeo columbano

  40. Ciprofibrate and triiodothyronine do not suppress in vivo induction of placental glutathione S-transferase expression in rat hepatocytes

    Article • Cancer Letters, April 2000, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  41. Early Increase in Cyclin-D1 Expression and Accelerated Entry of Mouse Hepatocytes into S Phase after Administration of the Mitogen 1,4-Bis[2-(3,5-Dichloropyridyloxy)] Benzene

    Article • American Journal Of Pathology, January 2000, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano

  42. Stimulation of rat liver growth by a single administration of lead nitrate

    Article • Toxicology and Applied Pharmacology, September 1982, Elsevier

    Dr. Andrea Perra, Professor amedeo columbano