All Stories

  1. Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase

    Article • Communications Biology, June 2018, Springer Science + Business Media

    Dr Sandra B Gabelli

  2. Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions

    Article • Nature Materials, November 2017, Springer Science + Business Media

    Dr Sandra B Gabelli

  3. Corrigendum to “Rapid PD-L1 detection in tumors with PET using a highly specific peptide” [Biochemical and Biophysical Research Communications 483/1 (2017) 258–263]

    Article • Biochemical and Biophysical Research Communications, September 2017, Elsevier

    Dr Sandra B Gabelli

  4. Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition

    Article • Journal of Biological Chemistry, July 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Sandra B Gabelli

  5. Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes

    Article • Molecular Biology of the Cell, July 2017, American Society for Cell Biology (ASCB)

    Dr Sandra B Gabelli

  6. A Tunable Brake for HECT Ubiquitin Ligases

    Article • Molecular Cell, May 2017, Elsevier

    Dr Sandra B Gabelli

  7. Intracellular production of hydrogels and synthetic RNA granules by multivalent enhancers

    Article • March 2017, Cold Spring Harbor Laboratory Press

    Dr Sandra B Gabelli

  8. Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design

    Article • Bioorganic & Medicinal Chemistry, February 2017, Elsevier

    Dr Sandra B Gabelli

  9. Rapid PD-L1 detection in tumors with PET using a highly specific peptide

    Article • Biochemical and Biophysical Research Communications, January 2017, Elsevier

    Dr Sandra B Gabelli

  10. Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis

    Article • Journal of Bioenergetics and Biomembranes, September 2016, Springer Science + Business Media

    Dr Sandra B Gabelli

  11. Nudix hydrolases degrade protein-conjugated ADP-ribose

    Article • Scientific Reports, December 2015, Springer Science + Business Media

    Dr Sandra B Gabelli

  12. Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus

    Article • PLoS ONE, November 2015, PLOS

    Dr Sandra B Gabelli

  13. Calmodulin and Ca2+control of voltage gated Na+channels

    Article • Channels, July 2015, Taylor & Francis

    Dr Sandra B Gabelli

  14. Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes

    Article • Proceedings of the National Academy of Sciences, July 2015, Proceedings of the National Academy of Sciences

    Dr Sandra B Gabelli

  15. Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α

    Article • FEBS Journal, July 2015, Wiley

    Dr Leon Mario Amzel, Dr Sandra B Gabelli

  16. A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development

    Article • PLoS Pathogens, April 2015, PLOS

    Dr Sandra B Gabelli

  17. A Nudix Hydrolase Necessary for Mycobacterium Tuberculosis Survival under Oxidative Stress

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Leon Mario Amzel, Dr Sandra B Gabelli

  18. Cardiac Sodium Channel: Activation by CaM Involves a NaV1.5-NaV1.5 Interaction

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Leon Mario Amzel, Dr Sandra B Gabelli

  19. Regulation of the NaV1.5 cytoplasmic domain by calmodulin

    Article • Nature Communications, November 2014, Springer Science + Business Media

    Dr Leon Mario Amzel, Dr Sandra B Gabelli

  20. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates

    Article • Acta Crystallographica Section D Biological Crystallography, February 2014, International Union of Crystallography

    Dr Leon Mario Amzel, Dr Sandra B Gabelli

  21. Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects

    Article • Biophysical Reviews, January 2014, Springer Science + Business Media

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  22. Gel Filtration Chromatography (Size Exclusion Chromatography) of Proteins

    Article • January 2014, Elsevier

    Dr Sandra B Gabelli

  23. Salting out of Proteins Using Ammonium Sulfate Precipitation

    Article • January 2014, Elsevier

    Dr Sandra B Gabelli

  24. Explanatory Chapter: Troubleshooting Recombinant Protein Expression

    Article • January 2014, Elsevier

    Dr Sandra B Gabelli

  25. Explanatory Chapter: Troubleshooting Protein Expression

    Article • January 2014, Elsevier

    Dr Sandra B Gabelli

  26. Using Ion Exchange Chromatography to Purify a Recombinantly Expressed Protein

    Article • January 2014, Elsevier

    Dr Sandra B Gabelli

  27. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

    Article • eLife, July 2013, eLife

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  28. A UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan Biosynthesis

    Article • PLoS ONE, May 2013, PLOS

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  29. Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells

    Article • Journal of Medicinal Chemistry, May 2013, American Chemical Society (ACS)

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  30. Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

    Article • Bioorganic & Medicinal Chemistry, May 2013, Elsevier

    Dr Sandra B Gabelli

  31. Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

    Article • Journal of Medicinal Chemistry, July 2012, American Chemical Society (ACS)

    Dr Sandra B Gabelli, Dr Leon Mario Amzel, Professor Roberto Docampo

  32. Structural studies of the Nudix GDP‐mannose hydrolase from E. coli reveals a new motif for mannose recognition

    Article • Proteins Structure Function and Bioinformatics, June 2011, Wiley

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  33. The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities

    Article • Journal of Bacteriology, April 2011, ASM Journals

    Dr Sandra B Gabelli

  34. Inhibitors of Leishmania Major Farnesyl Diphosphate Synthase: Crystallographic and Calorimetric Studies

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  35. CDP-Chase, a CDP-Choline Pyrophosphatase, is a Member of a Novel Nudix Family in Gram-Positive Bacteria

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  36. Capitalizing on tumor genotyping: Towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase

    Article • Advances in Enzyme Regulation, January 2011, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  37. Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic Acid

    Article • The Plant Cell, September 2010, American Society of Plant Biologists (ASPB)

    Dr Sandra B Gabelli

  38. NHE3 Activity Is Dependent on Direct Phosphoinositide Binding at the N Terminus of Its Intracellular Cytosolic Region

    Article • Journal of Biological Chemistry, August 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Sandra B Gabelli

  39. Mutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CLpro,

    Article • Biochemistry, May 2010, American Chemical Society (ACS)

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  40. T1871 NHE3 Activity is Dependent on Direct Phosphatidylinositide Binding at Its Proximal Cytosolic Region

    Article • Gastroenterology, May 2010, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  41. Somatic mutations in PI3Kα: Structural basis for enzyme activation and drug design

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, March 2010, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  42. Structural Effects of Oncogenic PI3Kα Mutations

    Article • January 2010, Springer Science + Business Media

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  43. Binding of nitrogen‐containing bisphosphonates (N‐BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

    Article • Proteins Structure Function and Bioinformatics, October 2009, Wiley

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  44. A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

    Article • Proceedings of the National Academy of Sciences, October 2009, Proceedings of the National Academy of Sciences

    Dr Sandra B Gabelli

  45. Structure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus

    Article • Structure, March 2009, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  46. Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase

    Article • Journal of Bacteriology, October 2008, ASM Journals

    Dr Sandra B Gabelli

  47. Structural comparisons of class I phosphoinositide 3-kinases

    Article • Nature Reviews Cancer, July 2008, Springer Science + Business Media

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  48. Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

    Article • Chemical Biology & Drug Design, June 2008, Wiley

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  49. Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110α/p85α

    Article • Cell Cycle, May 2008, Taylor & Francis

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  50. The Structure of a Human p110 /p85  Complex Elucidates the Effects of Oncogenic PI3K  Mutations

    Article • Science, December 2007, American Association for the Advancement of Science

    Dr Sandra B Gabelli

  51. Structure and Function of the E. coli Dihydroneopterin Triphosphate Pyrophosphatase: A Nudix Enzyme Involved in Folate Biosynthesis

    Article • Structure, August 2007, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  52. X-ray, NMR, and Mutational Studies of the Catalytic Cycle of the GDP-Mannose Mannosyl Hydrolase Reaction,

    Article • Biochemistry, August 2006, American Chemical Society (ACS)

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  53. Hydrogen bonding in the mechanism of GDP-mannose mannosyl hydrolase

    Article • Journal of Molecular Structure, June 2006, Elsevier

    Dr Sandra B Gabelli

  54. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design

    Article • Proteins Structure Function and Bioinformatics, November 2005, Wiley

    Dr Sandra B Gabelli, Dr Leon Mario Amzel, Professor Roberto Docampo

  55. Structure and activity of the axon guidance protein MICAL

    Article • Proceedings of the National Academy of Sciences, November 2005, Proceedings of the National Academy of Sciences

    Dr Sandra B Gabelli

  56. C-terminal Recognition by 14-3-3 Proteins for Surface Expression of Membrane Receptors

    Article • Journal of Biological Chemistry, August 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Sandra B Gabelli

  57. Mutational, Structural, and Kinetic Evidence for a Dissociative Mechanism in the GDP-Mannose Mannosyl Hydrolase Reaction

    Article • Biochemistry, June 2005, American Chemical Society (ACS)

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  58. Structures and mechanisms of Nudix hydrolases

    Article • Archives of Biochemistry and Biophysics, January 2005, Elsevier

    Dr Sandra B Gabelli

  59. Structure and Mechanism of GDP-Mannose Glycosyl Hydrolase, a Nudix Enzyme that Cleaves at Carbon Instead of Phosphorus

    Article • Structure, June 2004, Elsevier

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  60. Structure and Mechanism of MT-ADPRase, a Nudix Hydrolase from Mycobacterium tuberculosis

    Article • Structure, August 2003, Elsevier

    Dr Sandra B Gabelli

  61. Structure of a Coenzyme A Pyrophosphatase from Deinococcus radiodurans: a Member of the Nudix Family

    Article • Journal of Bacteriology, July 2003, ASM Journals

    Dr Sandra B Gabelli

  62. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

    Article • Nature, February 2003, Springer Science + Business Media

    Dr Sandra B Gabelli

  63. Mechanism of the Escherichia coli ADP-Ribose Pyrophosphatase, a Nudix Hydrolase,

    Article • Biochemistry, July 2002, American Chemical Society (ACS)

    Dr Sandra B Gabelli, Dr Leon Mario Amzel

  64. Article • Nature Structural Biology, May 2001, Springer Science + Business Media

    Dr Sandra B Gabelli