All Stories

  1. Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α
  2. Role of the Outer Pore Domain in Transient Receptor Potential Vanilloid 1 Dynamic Permeability to Large Cations
  3. A Nudix Hydrolase Necessary for Mycobacterium Tuberculosis Survival under Oxidative Stress
  4. A Novel Approach to Analyzing Binding Data from Na+ Driven Transporters: Beyond Non-Integer Hill Coefficients
  5. Effect of Mutations on Transport by the Sodium/Iodide Symporter (NIS)
  6. Cardiac Sodium Channel: Activation by CaM Involves a NaV1.5-NaV1.5 Interaction
  7. Regulation of the NaV1.5 cytoplasmic domain by calmodulin
  8. Physiological sodium concentrations enhance the iodide affinity of the Na+/I− symporter
  9. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates
  10. Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects
  11. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis
  12. A UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan Biosynthesis
  13. Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells
  14. Coordination of peroxide to the CuM center of peptidylglycine α-hydroxylating monooxygenase (PHM): structural and computational study
  15. Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2
  16. Estimation of Free-Energy Differences from Computed Work Distributions: An Application of Jarzynski’s Equality
  17. Design, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase
  18. Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects
  19. Coordination of Hydrogen Peroxide by a Copper Center in Peptidylglycine Alpha-Hydroxylating Monooxygenase (PHM). Structural and Computational Study
  20. Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
  21. Peptidyl-α-Hydroxyglycine α-Amidating Lyase (PAL)
  22. Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity
  23. Structural studies of the Nudix GDP‐mannose hydrolase from E. coli reveals a new motif for mannose recognition
  24. Disaccharide Binding to Galectin-1: Free Energy Calculations and Molecular Recognition Mechanism
  25. The Hypoxic Regulator of Sterol Synthesis Nro1 Is a Nuclear Import Adaptor
  26. Inhibitors of Leishmania Major Farnesyl Diphosphate Synthase: Crystallographic and Calorimetric Studies
  27. CDP-Chase, a CDP-Choline Pyrophosphatase, is a Member of a Novel Nudix Family in Gram-Positive Bacteria
  28. Crystal Structure of the C-Terminal Domain of the Hypoxia Regulator Ofd1
  29. Direct Activation of Epac by Sulfonylurea Is Isoform Selective
  30. Disaccharide Binding to Galectin-1: Free Energy Calculations and Insight of the Molecular Recognition Mechanism
  31. Capitalizing on tumor genotyping: Towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase
  32. Peptidyl-α-Hydroxyglycine α-Amidating Lyase (PAL)
  33. Peptidylglycine α-Hydroxylating Monooxygenase (PHM)
  34. Differential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase
  35. Structure and Specificity of a Binary Tandem Domain F-Lectin from Striped Bass (Morone saxatilis)
  36. α-Helix peptides designed from EBV-gH protein display higher antigenicity and induction of monocyte apoptosis than the native peptide
  37. Mutation of Asn28 Disrupts the Dimerization and Enzymatic Activity of SARS 3CLpro,
  38. T1871 NHE3 Activity is Dependent on Direct Phosphatidylinositide Binding at Its Proximal Cytosolic Region
  39. Somatic mutations in PI3Kα: Structural basis for enzyme activation and drug design
  40. How Much Binding Affinity Can be Gained by Filling a Cavity?
  41. Structural Effects of Oncogenic PI3Kα Mutations
  42. Helix propensities calculations for amino acids in alanine based peptides using Jarzynski's equality
  43. Binding of nitrogen‐containing bisphosphonates (N‐BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer
  44. Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme
  45. Impact of linker strain and flexibility in the design of a fragment-based inhibitor
  46. Structure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus
  47. Correctly folded proteins make twice as many hydrophobic contacts
  48. Structural Aspects of Lectin–Ligand Interactions
  49. F-Type Lectins
  50. Structural comparisons of class I phosphoinositide 3-kinases
  51. Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro
  52. Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110α/p85α
  53. Structure, Function, and Mechanism of Cytosolic Quinone Reductases
  54. Enzymatic capture of an extrahelical thymine in the search for uracil in DNA
  55. Structure and Function of the E. coli Dihydroneopterin Triphosphate Pyrophosphatase: A Nudix Enzyme Involved in Folate Biosynthesis
  56. Making the Right Moves
  57. Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization
  58. Faculty Opinions recommendation of Structure of a heparin-dependent complex of Hedgehog and Ihog.
  59. The Catalytic Mechanism of Peptidylglycine α-Hydroxylating Monooxygenase Investigated by Computer Simulation
  60. X-ray, NMR, and Mutational Studies of the Catalytic Cycle of the GDP-Mannose Mannosyl Hydrolase Reaction,
  61. Mechanism of Titin Unfolding by Force: Insight from Quasi-Equilibrium Molecular Dynamics Calculations
  62. Faculty Opinions recommendation of Verification of the Crooks fluctuation theorem and recovery of RNA folding free energies.
  63. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design
  64. The Catalytic Copper of Peptidylglycine α-Hydroxylating Monooxygenase also Plays a Critical Structural Role
  65. Thermodynamic calculations in biological systems
  66. Faculty Opinions recommendation of Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket.
  67. Local conformational similarity between native and denatured states
  68. Faculty Opinions recommendation of A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.
  69. Mutational, Structural, and Kinetic Evidence for a Dissociative Mechanism in the GDP-Mannose Mannosyl Hydrolase Reaction
  70. Faculty Opinions recommendation of Structure of a glutamate transporter homologue from Pyrococcus horikoshii.
  71. Faculty Opinions recommendation of A synthetic conjugate polysaccharide vaccine against Haemophilus influenzae type b.
  72. Structure and Mechanism of GDP-Mannose Glycosyl Hydrolase, a Nudix Enzyme that Cleaves at Carbon Instead of Phosphorus
  73. A structural and thermodynamic escape mechanism from a drug resistant mutation of the HIV-1 protease
  74. Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)
  75. Faculty Opinions recommendation of Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity.
  76. Loss of translational entropy in molecular associations
  77. Role of Entropy in Increased Rates of Intramolecular Reactions
  78. Electrostatic Guidance of Glycosyl Cation Migration along the Reaction Coordinate of Uracil DNA Glycosylase,
  79. On the molecular basis of the recognition of angiotensin II (AII)
  80. Faculty Opinions recommendation of Structure and mechanism of the lactose permease of Escherichia coli.
  81. Faculty Opinions recommendation of Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab.
  82. Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)
  83. Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)
  84. Interactions of the Products, 8-Oxo-dGMP, dGMP, and Pyrophosphate with the MutT Nucleoside Triphosphate Pyrophosphohydrolase †
  85. Faculty Opinions recommendation of Structure of the extracellular region of HER3 reveals an interdomain tether.
  86. Na+/I−Symporter Activity Requires a Small and Uncharged Amino Acid Residue at Position 395
  87. Mechanism of the Escherichia coli ADP-Ribose Pyrophosphatase, a Nudix Hydrolase,
  88. A novel fucose recognition fold involved in innate immunity
  89. Faculty Opinions recommendation of Probing protein electrostatics with a synthetic fluorescent amino acid.
  90. Anti-Idiotypic Antibodies
  91. Characterization of a Mechanism-Based Inhibitor of NAD(P)H:Quinone Oxidoreductase 1 by Biochemical, X-ray Crystallographic, and Mass Spectrometric Approaches †
  92. Structure-Based Development of Anticancer Drugs
  93. Mechanism of NAD(P)H:Quinone reductase: Ab initio studies of reduced flavin
  94. Structure, Motion, Interaction and Expression of Biological Macromolecules R. H. Sarma M. H. Sarma
  95. Mechanism of NAD(P)H:Quinone reductase: Ab initio studies of reduced flavin
  96. Structures of mammalian cytosolic quinone reductases
  97. Soluble ?-galactosyl-binding lectin (galectin) from toad ovary: Crystallographic studies of two protein-sugar complexes
  98. Binding of small organic molecules to macromolecular targets: Evaluation of conformational entropy changes
  99. Binding of small organic molecules to macromolecular targets: Evaluation of conformational entropy changes
  100. Crystal Structure of Human Quinone Reductase Type 2, a Metalloflavoprotein † , ‡
  101. Structure of F1 -ATPase and the Mechanism of ATP Synthesis— Hydrolysis
  102. Structure-based drug design
  103. Thermodynamics of Bovine Spleen Galectin-1 Binding to Disaccharides: Correlation with Structure and Its Effect on Oligomerization at the Denaturation Temperature †
  104. Relation between positional specificity and chirality in mammalian lipoxygenases
  105. Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme
  106. Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme
  107. Loss of translational entropy in binding, folding, and catalysis
  108. Loss of translational entropy in binding, folding, and catalysis
  109. Galectins from Amphibian Species: Carbohydrate Specificity, Molecular Structure, and Evolution.
  110. The Three-Dimensional Structure of Soybean Lipoxygenase-1: An Arachidonic Acid 15-Lipoxygenase
  111. The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition
  112. Lipoxygenases
  113. The magnitude of the backbone conformational entropy change in protein folding
  114. The magnitude of the backbone conformational entropy change in protein folding
  115. Structure conservation in lipoxygenases: Structural analysis of soybean lipoxygenase-1 and modeling of human lipoxygenases
  116. Structure conservation in lipoxygenases: Structural analysis of soybean lipoxygenase‐1 and modeling of human lipoxygenases
  117. Estimation of changes in side chain configurational entropy in binding and folding: General methods and application to helix formation
  118. The three-dimensional structure of rat liver mitochodria F1-ATPase: X-ray diffraction studies
  119. Structure of F0F1ATPases Determined by Direct and Indirect Methods
  120. Entropy in biological binding processes: Estimation of translational entropy loss
  121. Sodium- and chloride-dependent transporters in brain, kidney, and gut
  122. Structural energetics of peptide recognition: Angiotensin II/antibody binding
  123. Kinetics of A Glycine for Arg-47 Human Alcohol Dehydrogenase Mutant Can be Explained by Lys-228 Recruitment into the Pyrophosphate Binding Site
  124. F-type ATPases: Are Nucleotide Domains in Adenylate Kinase Appropriate Models for Nucleotide Domains in ATP Synthase/ATPase Complexes?
  125. Modeling the variable region of immunoglobulins
  126. Introduction
  127. Quaternary structure of ATP synthases: Symmetry and asymmetry in the F1 moiety
  128. ATP synthase: structure-function relationships
  129. Recognition in cell adhesion. A comparative study of the conformations of RGD-containing peptides by Monte Carlo and NMR methods
  130. ATP synthases?Structure of the F1-moiety and its relationship to function and mechanism
  131. Preliminary x-ray diffraction analysis ofHhaII endonuclease-DNA cocrystals
  132. Calculating three-dimensional changes in protein structure due to amino-acid substitutions: The variable region of immunoglobulins
  133. True identity of a diffraction pattern attributed to valyl tRNA
  134. THE THREE-DIMENSIONAL STRUCTURE OF F1ATPases
  135. Structure of F1-ATPases
  136. The ATP Synthesizing System of Liver Mitochondria