All Stories

  1. RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions

    Article • Journal of Parkinson s Disease, July 2023, IOS Press

    Professor Tiago F Outeiro

  2. miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy

    Article • Journal of Parkinson s Disease, March 2023, IOS Press

    Professor Tiago F Outeiro

  3. Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity

    Article • Journal of Parkinson s Disease, December 2022, IOS Press

    Professor Tiago F Outeiro

  4. Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease

    Article • Journal of Parkinson s Disease, February 2018, IOS Press

    Professor Tiago F Outeiro

  5. α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

    Article • Neurobiology of Disease, October 2014, Elsevier

    Professor Tiago F Outeiro

  6. Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells

    Article • Molecular and Cellular Neuroscience, September 2014, Elsevier

    Professor Tiago F Outeiro

  7. Protein phosphorylation in neurodegeneration: friend or foe?

    Article • Frontiers in Molecular Neuroscience, May 2014, Frontiers

    Professor Tiago F Outeiro

  8. Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease

    Article • PLoS Genetics, May 2014, PLOS

    Professor Tiago F Outeiro

  9. Challenges and Promises in the Development of Neurotrophic Factor-Based Therapies for Parkinson’s Disease

    Article • Drugs & Aging, March 2014, Springer Science + Business Media

    Professor Tiago F Outeiro

  10. Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator

    Article • Lab on a Chip, January 2014, Royal Society of Chemistry

    Joao Conde, Professor Tiago F Outeiro

  11. Studying the Molecular Determinants of Protein Oligomerization in Neurodegenerative Disorders by Bimolecular Fluorescence Complementation

    Article • January 2014, Elsevier

    Professor Tiago F Outeiro

  12. MeCP2: a novel Huntingtin interactor

    Article • Human Molecular Genetics, October 2013, Oxford University Press (OUP)

    Professor Tiago F Outeiro

  13. Off-pathwayα-synuclein oligomers seem to alterα-synuclein turnover in a cell model but lack seeding capabilityin vivo

    Article • Amyloid, September 2013, Taylor & Francis

    Professor Tiago F Outeiro

  14. The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

    Article • The EMBO Journal, September 2013, Wiley

    Professor Tiago F Outeiro

  15. Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, August 2013, Elsevier

    Professor Tiago F Outeiro

  16. P4–053: Alpha‐synuclein oligomers can act as seed in a fibrillation assay but do not cause increased aggregation in living cells

    Article • Alzheimer s & Dementia, July 2013, Wiley

    Professor Tiago F Outeiro

  17. β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons

    Article • Annals of Neurology, July 2013, Wiley

    Professor Tiago F Outeiro

  18. PLK2 Modulates α-Synuclein Aggregation in Yeast and Mammalian Cells

    Article • Molecular Neurobiology, May 2013, Springer Science + Business Media

    Professor Tiago F Outeiro

  19. Harnessing the power of yeast to unravel the molecular basis of neurodegeneration

    Article • Journal of Neurochemistry, May 2013, Wiley

    Professor Tiago F Outeiro

  20. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease

    Article • Journal of Molecular Medicine, May 2013, Springer Science + Business Media

    Professor Tiago F Outeiro

  21. alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology

    Article • Journal of Molecular Medicine, April 2013, Springer Science + Business Media

    Professor Tiago F Outeiro

  22. Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications

    Article • Journal of Neurochemistry, April 2013, Wiley

    Professor Tiago F Outeiro

  23. Crystal Structure of kynurenine 3-monooxygenase - truncated at position 394 plus HIS tag cleaved.

    Article • April 2013, Protein Data Bank, Rutgers University

    Professor Tiago F Outeiro

  24. Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)

    Article • April 2013, Protein Data Bank, Rutgers University

    Professor Tiago F Outeiro

  25. Crystal Structure of kynurenine 3-monooxygenase (KMO-394)

    Article • April 2013, Protein Data Bank, Rutgers University

    Professor Tiago F Outeiro

  26. Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot)

    Article • April 2013, Protein Data Bank, Rutgers University

    Professor Tiago F Outeiro

  27. Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot-Se)

    Article • April 2013, Protein Data Bank, Rutgers University

    Professor Tiago F Outeiro

  28. Structural basis of kynurenine 3-monooxygenase inhibition

    Article • Nature, April 2013, Springer Science + Business Media

    Professor Tiago F Outeiro

  29. Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

    Article • Journal of Neurochemistry, March 2013, Wiley

    Professor Tiago F Outeiro

  30. Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system

    Article • Biochemical Pharmacology, March 2013, Elsevier

    Professor Tiago F Outeiro

  31. SIRT1 and SIRT2: emerging targets in neurodegeneration

    Article • EMBO Molecular Medicine, February 2013, EMBO

    Professor Tiago F Outeiro

  32. Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy

    Article • Molecular Neurobiology, February 2013, Springer Science + Business Media

    Professor Tiago F Outeiro

  33. Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice

    Article • Neurobiology of Aging, February 2013, Elsevier

    Professor Tiago F Outeiro

  34. Sirtuins in Biology and Disease

    Article • January 2013

    Professor Tiago F Outeiro

  35. The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival

    Article • Brain Research Bulletin, January 2013, Elsevier

    Professor Tiago F Outeiro

  36. LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

    Article • Journal of Molecular Medicine, November 2012, Springer Science + Business Media

    Professor Tiago F Outeiro

  37. Parkinson’s disease-associated mutations in DJ-1 modulate its dimerization in living cells

    Article • Journal of Molecular Medicine, November 2012, Springer Science + Business Media

    Professor Tiago F Outeiro

  38. SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

    Article • Autophagy, October 2012, Taylor & Francis

    Professor Tiago F Outeiro, Paula Ludovico

  39. Epigenetic regulation of BACE1 in Alzheimer’s disease patients and in transgenic mice

    Article • Neuroscience, September 2012, Elsevier

    Professor Tiago F Outeiro

  40. B10 The role of n-terminal phosphorylation in huntingtin's oligomerisation, aggregation and toxicity

    Article • Journal of Neurology Neurosurgery & Psychiatry, August 2012, BMJ

    Professor Tiago F Outeiro

  41. Epigenetics in Parkinson’s and Alzheimer’s Diseases

    Article • June 2012, Springer Science + Business Media

    Professor Tiago F Outeiro

  42. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

    Article • Neurobiology of Aging, June 2012, Elsevier

    Professor Tiago F Outeiro

  43. Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease

    Article • EMBO Molecular Medicine, May 2012, EMBO

    Professor Tiago F Outeiro

  44. Novel Molecular Therapeutics in Parkinson's Disease

    Article • February 2012, Wiley

    Professor Tiago F Outeiro

  45. High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment

    Article • Biomicrofluidics, February 2012, American Institute of Physics

    Professor Tiago F Outeiro

  46. Editorial on Special Topic: Sirtuins in Metabolism, Aging, and Disease

    Article • Frontiers in Pharmacology, January 2012, Frontiers

    Professor Tiago F Outeiro

  47. SIRT2 as a Therapeutic Target for Age-Related Disorders

    Article • Frontiers in Pharmacology, January 2012, Frontiers

    Professor Tiago F Outeiro

  48. Imaging Protein Oligomerization in Neurodegeneration Using Bimolecular Fluorescence Complementation

    Article • January 2012, Elsevier

    Professor Tiago F Outeiro

  49. Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice

    Article • PLoS ONE, December 2011, PLOS

    Professor Tiago F Outeiro, Dr L. Miguel Martins

  50. Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes

    Article • Bioorganic & Medicinal Chemistry, December 2011, Elsevier

    Professor Tiago F Outeiro

  51. α-Synuclein modifies huntingtin aggregation in living cells

    Article • FEBS Letters, November 2011, Wiley

    Professor Tiago F Outeiro

  52. Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice

    Article • Journal of the Neurological Sciences, November 2011, Elsevier

    Professor Tiago F Outeiro

  53. Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells

    Article • PLoS ONE, October 2011, PLOS

    Professor Tiago F Outeiro

  54. Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy

    Article • PLoS ONE, October 2011, PLOS

    Professor Tiago F Outeiro, Jordi Clarimon

  55. Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

    Article • PLoS ONE, October 2011, PLOS

    Professor Tiago F Outeiro

  56. Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast

    Article • Biochemical Society Transactions, October 2011, Portland Press Ltd.

    Professor Tiago F Outeiro

  57. FlAsH illuminates Aβ aggregation

    Article • Nature Chemical Biology, August 2011, Springer Science + Business Media

    Professor Tiago F Outeiro

  58. Impaired Proteostasis Contributes to Renal Tubular Dysgenesis

    Article • PLoS ONE, June 2011, PLOS

    Professor Tiago F Outeiro

  59. Assessment of the Efficacy of Solutes from Extremophiles on Protein Aggregation in Cell Models of Huntington’s and Parkinson’s Diseases

    Article • Neurochemical Research, March 2011, Springer Science + Business Media

    Professor Tiago F Outeiro

  60. Epigenetics in neurodegeneration: A new layer of complexity

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, March 2011, Elsevier

    Professor Tiago F Outeiro

  61. Visualization of cell-to-cell transmission of mutant huntingtin oligomers

    Article • PLoS Currents, February 2011, PLOS

    Professor Tiago F Outeiro

  62. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

    Article • Journal of Clinical Investigation, February 2011, American Society for Clinical Investigation

    Professor Tiago F Outeiro

  63. Editorial [Hot Topic: Drug Discovery for CNS Disorders: From Bench to Bedside (Guest Editor: Tiago Fleming Outeiro)]

    Article • CNS & Neurological Disorders - Drug Targets, December 2010, Bentham Science Publishers

    Professor Tiago F Outeiro

  64. Neurotrophic Factors as a Protective Strategy in Parkinsons Disease

    Article • CNS & Neurological Disorders - Drug Targets, December 2010, Bentham Science Publishers

    Professor Tiago F Outeiro

  65. Simple is good: yeast models of neurodegeneration

    Article • FEMS Yeast Research, November 2010, Oxford University Press (OUP)

    Professor Tiago F Outeiro

  66. Zooming into protein oligomerization in neurodegeneration using BiFC

    Article • Trends in Biochemical Sciences, November 2010, Elsevier

    Professor Tiago F Outeiro

  67. Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner

    Article • PLoS ONE, October 2010, PLOS

    Professor Tiago F Outeiro

  68. Sirtuins: Common Targets in Aging and in Neurodegeneration

    Article • Current Drug Targets, October 2010, Bentham Science Publishers

    Professor Tiago F Outeiro

  69. Synaptic Dysfunction in Parkinson’s Disease: From Protein Misfolding to Functional Alterations

    Article • September 2010, Springer Science + Business Media

    Professor Tiago F Outeiro

  70. A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS

    Article • PROTEOMICS - CLINICAL APPLICATIONS, June 2010, Wiley

    Professor Tiago F Outeiro

  71. Increased serum HSP70 levels are associated with the duration of diabetes

    Article • Cell Stress and Chaperones, May 2010, Springer Science + Business Media

    Professor Tiago F Outeiro

  72. The sour side of neurodegenerative disorders: the effects of protein glycation

    Article • The Journal of Pathology, December 2009, Wiley

    Professor Tiago F Outeiro

  73. Current and Future Therapeutic Strategies for Parkinsons Disease

    Article • Current Pharmaceutical Design, December 2009, Bentham Science Publishers

    Professor Tiago F Outeiro

  74. P3.009 Aging and neurodegeneration: common targets, common hopes

    Article • Parkinsonism & Related Disorders, December 2009, Elsevier

    Professor Tiago F Outeiro

  75. Dopamine-Induced Conformational Changes in Alpha-Synuclein

    Article • PLoS ONE, September 2009, PLOS

    Professor Tiago F Outeiro

  76. Novel insights into alpha syynuclein intracellular dynamics

    Article • Frontiers in Neuroscience, January 2009, Frontiers

    Professor Tiago F Outeiro

  77. Dopamine-Induced Conformational Changes in a-Synuclein

    Article • Frontiers in Neuroscience, January 2009, Frontiers

    Professor Tiago F Outeiro

  78. Unraveling the role of A-synuclein phosphorylation in the etiology of parkinson's disease

    Article • Frontiers in Neuroscience, January 2009, Frontiers

    Professor Tiago F Outeiro

  79. Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

    Article • Experimental Neurology, October 2008, Elsevier

    Professor Tiago F Outeiro

  80. From Mad Cows to Neurotic Yeast: Novel Molecular Approaches to Understand Neurodegeneration

    Article • Microscopy and Microanalysis, September 2008, Cambridge University Press

    Professor Tiago F Outeiro

  81. Therapeutic role of sirtuins in neurodegenerative disease

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, June 2008, Elsevier

    Professor Tiago F Outeiro

  82. Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

    Article • PLoS ONE, May 2008, PLOS

    Professor Tiago F Outeiro

  83. CHIP Targets Toxic  -Synuclein Oligomers for Degradation

    Article • Journal of Biological Chemistry, April 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Tiago F Outeiro

  84. Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

    Article • PLoS ONE, April 2008, PLOS

    Professor Tiago F Outeiro

  85. Yeast as a model for studying human neurodegenerative disorders

    Article • Biotechnology Journal, March 2008, Wiley

    Professor Tiago F Outeiro

  86. Yeast as a model for studying human neurodegenerative disorders

    Article • Biotechnology Journal, March 2008, Wiley

    Professor Tiago F Outeiro

  87. Detection of Compounds That Rescue Rab1‐Synuclein Toxicity

    Article • January 2008, Elsevier

    Professor Tiago F Outeiro

  88. Angiotensin II protects against α-synuclein toxicity and reduces protein aggregation in vitro

    Article • Biochemical and Biophysical Research Communications, November 2007, Elsevier

    Professor Tiago F Outeiro

  89. Pharmacological inhibition of PARP-1 reduces α-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models

    Article • Biochemical and Biophysical Research Communications, June 2007, Elsevier

    Professor Tiago F Outeiro

  90. Mechanisms of Disease II: Cellular Protein Quality Control

    Article • Seminars in Pediatric Neurology, March 2007, Elsevier

    Professor Tiago F Outeiro, Julie Tetzalff

  91. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra

    Article • Journal of Neurochemistry, January 2007, Wiley

    Professor Tiago F Outeiro

  92. Protein Aggregation Disorders

    Article • January 2007, Elsevier

    Professor Tiago F Outeiro

  93. Small heat shock proteins protect against α-synuclein-induced toxicity and aggregation

    Article • Biochemical and Biophysical Research Communications, December 2006, Elsevier

    Professor Tiago F Outeiro

  94. Yeast as a drug discovery platform in Huntington's and Parkinson's diseases

    Article • Biotechnology Journal, March 2006, Wiley

    Professor Tiago F Outeiro

  95. Stress Tolerance, Metabolism, and Development

    Article • October 2005, Taylor & Francis

    Professor Tiago F Outeiro

  96. Yeast Cells as a Discovery Platform for Neurodegenerative Disease

    Article • January 2005, Springer Science + Business Media

    Professor Tiago F Outeiro

  97. Molecular Genetics Approaches in Yeast to Study Amyloid Diseases

    Article • Journal of Molecular Neuroscience, January 2004, Springer Science + Business Media

    Professor Tiago F Outeiro

  98. Interactions Among α-Synuclein, Dopamine, and Biomembranes: Some Clues for Understanding Neurodegeneration in Parkinson's Disease

    Article • Journal of Molecular Neuroscience, January 2004, Springer Science + Business Media

    Professor Tiago F Outeiro

  99. Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

    Article • Science, December 2003, American Association for the Advancement of Science

    Professor Tiago F Outeiro

  100. Prion protein gene polymorphisms in Saccharomyces cerevisiae

    Article • Molecular Microbiology, July 2003, Wiley

    Professor Tiago F Outeiro