All Stories

  1. Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model

    Article • Proceedings of the National Academy of Sciences, February 2021, Proceedings of the National Academy of Sciences

    Dr Nathaniel J Szewczyk

  2. Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans

    Article • iScience, February 2021, Elsevier

    Dr Nathaniel J Szewczyk

  3. Links Between Testosterone, Oestrogen, and the Growth Hormone/Insulin-Like Growth Factor Axis and Resistance Exercise Muscle Adaptations

    Article • Frontiers in Physiology, January 2021, Frontiers

    Dr Nathaniel J Szewczyk

  4. The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo

    Article • The Journal of Physiology, December 2020, Wiley

    Dr Nathaniel J Szewczyk

  5. A New Era for Space Life Science: International Standards for Space Omics Processing

    Article • Patterns, December 2020, Elsevier

    Dr Nathaniel J Szewczyk

  6. Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity in Caenorhabditis elegans

    Article • iScience, December 2020, Elsevier

    Dr Nathaniel J Szewczyk

  7. Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy

    Article • Molecular Metabolism, December 2020, Elsevier

    Dr Nathaniel J Szewczyk

  8. Revamping Space-omics in Europe

    Article • Cell Systems, December 2020, Elsevier

    Dr Nathaniel J Szewczyk

  9. Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Dr Nathaniel J Szewczyk

  10. NemaLife chip: a micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans

    Article • Scientific Reports, October 2020, Springer Science + Business Media

    Dr Nathaniel J Szewczyk

  11. Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments

    Article • Astrobiology, August 2020, Mary Ann Liebert Inc

    Dr Nathaniel J Szewczyk

  12. Network analysis of human muscle adaptation to aging and contraction

    Article • Aging, January 2020, Impact Journals, LLC

    Dr Nathaniel J Szewczyk

  13. Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans

    Article • Scientific Reports, October 2019, Springer Science + Business Media

    Dr Nathaniel J Szewczyk

  14. Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men

    Article • Journal of Cachexia Sarcopenia and Muscle, September 2019, Wiley

    Dr Nathaniel J Szewczyk

  15. Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae

    Article • International Journal of Molecular Sciences, August 2019, MDPI AG

    Dr Nathaniel J Szewczyk

  16. Mitochondrial dysfunction causes Ca2+ overload and ECM degradation–mediated muscle damage in C. elegans

    Article • The FASEB Journal, June 2019, Federation of American Societies For Experimental Biology (FASEB)

    Dr Nathaniel J Szewczyk, Kubota Yukihiko

  17. Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Dr Nathaniel J Szewczyk

  18. The acute transcriptional response to resistance exercise: impact of age and contraction mode

    Article • Aging, April 2019, Impact Journals, LLC

    Dr Nathaniel J Szewczyk

  19. Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans

    Article • Aging, November 2018, Impact Journals, LLC

    Dr Nathaniel J Szewczyk

  20. Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs

    Article • Disease Models & Mechanisms, November 2018, The Company of Biologists

    Dr Nathaniel J Szewczyk

  21. NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength ofC. elegans

    Article • Lab on a Chip, January 2018, Royal Society of Chemistry

    Dr Nathaniel J Szewczyk

  22. A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle

    Article • AJP Endocrinology and Metabolism, December 2017, American Physiological Society

    Dr Nathaniel J Szewczyk

  23. Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism

    Article • Clinical Nutrition, October 2017, Elsevier

    Dr Nathaniel J Szewczyk

  24. Muscle and Tendon Contributions to Reduced Rate of Torque Development in Healthy Older Males

    Article • The Journals of Gerontology Series A, August 2017, Oxford University Press (OUP)

    Dr Nathaniel J Szewczyk

  25. Phosphatases that regulate muscle protein degradation

    Article • Journal of Cachexia Sarcopenia and Muscle, May 2017, Wiley

    Dr Nathaniel J Szewczyk, Dr Susann Lehmann

  26. Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans

    Article • The Journal of Physiology, November 2016, Wiley

    Dr Nathaniel J Szewczyk

  27. Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development

    Article • Free Radical Biology and Medicine, July 2016, Elsevier

    Dr Nathaniel J Szewczyk

  28. An overview of technical considerations for Western blotting applications to physiological research

    Article • Scandinavian Journal of Medicine and Science in Sports, June 2016, Wiley

    Dr Nathaniel J Szewczyk

  29. Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling

    Article • npj Microgravity, April 2016, Nature

    Dr Nathaniel J Szewczyk

  30. Commentaries on Viewpoint: A call for research to assess and promote functional resilience in astronaut crewsCommentaries on Viewpoint: A call for research to assess and promote functional resilience in astronaut crewsCommentaries on Viewpoint: A call ...

    Article • Journal of Applied Physiology, February 2016, American Physiological Society

    Dr Nathaniel J Szewczyk

  31. Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans

    Article • npj Microgravity, January 2016, Nature

    Dr Nathaniel J Szewczyk

  32. Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling

    Article • The FASEB Journal, July 2015, Federation of American Societies For Experimental Biology (FASEB)

    Dr Nathaniel J Szewczyk

  33. Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adultC. elegansmuscle

    Article • Journal of Cachexia Sarcopenia and Muscle, June 2015, Wiley

    Dr Nathaniel J Szewczyk

  34. The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans

    Article • The FASEB Journal, December 2014, Federation of American Societies For Experimental Biology (FASEB)

    Dr Nathaniel J Szewczyk

  35. Methods to Assess Subcellular Compartments of Muscle in C. elegans

    Article • Journal of Visualized Experiments, November 2014, MyJove Corporation

    Dr Nathaniel J Szewczyk

  36. The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans

    Article • NeuroToxicology, March 2014, Elsevier

    Dr Nathaniel J Szewczyk

  37. Protective Role of DNJ-27/ERdj5 in Caenorhabditis elegans Models of Human Neurodegenerative Diseases

    Article • Antioxidants & Redox Signaling, January 2014, Mary Ann Liebert Inc

    Dr Nathaniel J Szewczyk

  38. Spaceflight and Ageing: Reflecting onCaenorhabditis elegansin Space

    Article • Gerontology, January 2014, Karger Publishers

    Dr Nathaniel J Szewczyk

  39. A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans

    Article • AJP Endocrinology and Metabolism, December 2013, American Physiological Society

    Dr Nathaniel J Szewczyk

  40. Knockdown of the C. elegans Kinome identifies Kinases required for normal protein Homeostasis, Mitochondrial network structure, and Sarcomere structure in muscle

    Article • Cell Communication and Signaling, September 2013, Springer Science + Business Media

    Dr Nathaniel J Szewczyk, Dr Susann Lehmann

  41. Space Flight Induces Reduction of Paramyosin and Troponin T: Proteomic Analysis of Space-Flown Caenorhabditis elegans

    Article • Current Biotechnology, September 2013, Bentham Science Publishers

    Dr Nathaniel J Szewczyk

  42. Space Flight Induces Reduction of Paramyosin and Troponin T: Proteomic Analysis of Space-Flown Caenorhabditis elegans

    Article • Current Biotechnology, August 2013, Bentham Science Publishers

    Dr Nathaniel J Szewczyk

  43. Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway

    Article • AJP Endocrinology and Metabolism, July 2013, American Physiological Society

    Dr Nathaniel J Szewczyk

  44. Evaluation of the fluids mixing enclosure system for life science experiments during a commercial Caenorhabditis elegans spaceflight experiment

    Article • Advances in Space Research, June 2013, Elsevier

    Dr Nathaniel J Szewczyk

  45. Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism

    Article • The Journal of Physiology, April 2013, Wiley

    Professor Stuart M Phillips, Dr Nathaniel J Szewczyk

  46. Using Multiple Phenotype Assays and Epistasis Testing to Enhance the Reliability of RNAi Screening and Identify Regulators of Muscle Protein Degradation

    Article • Genes, November 2012, MDPI AG

    Dr Nathaniel J Szewczyk, Dr Susann Lehmann

  47. Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans

    Article • NeuroToxicology, October 2012, Elsevier

    Dr Nathaniel J Szewczyk

  48. Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans

    Article • Scientific Reports, July 2012, Springer Science + Business Media

    Dr Nathaniel J Szewczyk

  49. Integrated control of protein degradation in C. elegans muscle

    Article • Worm, July 2012, Taylor & Francis

    Dr Nathaniel J Szewczyk, Dr Susann Lehmann

  50. Calpains Mediate Integrin Attachment Complex Maintenance of Adult Muscle in Caenorhabditis elegans

    Article • PLoS Genetics, January 2012, PLOS

    Dr Nathaniel J Szewczyk, Dr Susann Lehmann

  51. Remote automated multi-generational growth and observation of an animal in low Earth orbit

    Article • Journal of The Royal Society Interface, November 2011, Royal Society Publishing

    Dr Nathaniel J Szewczyk

  52. The next phase of life-sciences spaceflight research: Harnessing the power of functional genomics

    Article • Communicative & Integrative Biology, November 2011, Taylor & Francis

    Dr Nathaniel J Szewczyk

  53. Identification and Functional Clustering of Genes Regulating Muscle Protein Degradation from amongst the Known C. elegans Muscle Mutants

    Article • PLoS ONE, September 2011, PLOS

    Dr Nathaniel J Szewczyk

  54. The Effectiveness of RNAi in Caenorhabditis elegans Is Maintained during Spaceflight

    Article • PLoS ONE, June 2011, PLOS

    Dr Nathaniel J Szewczyk

  55. Chapter 5. Regulation of Muscle Proteostasis via Extramuscular Signals

    Article • January 2011, Royal Society of Chemistry

    Dr Nathaniel J Szewczyk

  56. Don't 'agonise' over the mechanisms underlying  -agonist-induced muscle hypertrophy!

    Article • The Journal of Physiology, January 2011, Wiley

    Dr Nathaniel J Szewczyk

  57. The Glutaredoxin GLRX-21 Functions to Prevent Selenium-Induced Oxidative Stress in Caenorhabditis elegans

    Article • Toxicological Sciences, September 2010, Oxford University Press (OUP)

    Dr Nathaniel J Szewczyk

  58. Cyclic stretch reduces myofibrillar protein synthesis despite increases in FAK and anabolic signalling in L6 cells

    Article • The Journal of Physiology, July 2009, Wiley

    Dr Nathaniel J Szewczyk

  59. Review of the results from the International C. elegans first experiment (ICE-FIRST)

    Article • Advances in Space Research, July 2009, Elsevier

    Dr Nathaniel J Szewczyk

  60. C. elegans RNAi space experiment (CERISE) in Japanese Experiment Module KIBO

    Article • Biological Sciences in Space, January 2009, Japanese Society for Biological Sciences in Space

    Dr Nathaniel J Szewczyk

  61. Description of International Caenorhabditis elegans Experiment first flight (ICE-FIRST)

    Article • Advances in Space Research, September 2008, Elsevier

    Dr Nathaniel J Szewczyk

  62. Genomic response of the nematode Caenorhabditis elegans to spaceflight

    Article • Advances in Space Research, January 2008, Elsevier

    Dr Nathaniel J Szewczyk

  63. unc-94 Encodes a Tropomodulin in Caenorhabditis elegans

    Article • Journal of Molecular Biology, December 2007, Elsevier

    Dr Nathaniel J Szewczyk

  64. Biochemical and molecular biological analyses of space-flown nematodes in Japan, the first international caenorhabditis elegans experiment (ICE-First)

    Article • Microgravity Science and Technology, September 2007, Springer Science + Business Media

    Dr Nathaniel J Szewczyk

  65. Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans

    Article • The EMBO Journal, February 2007, Wiley

    Dr Nathaniel J Szewczyk

  66. Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station

    Article • Advances in Space Research, January 2007, Elsevier

    Dr Nathaniel J Szewczyk

  67. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction

    Article • Journal of Experimental Biology, October 2006, The Company of Biologists

    Dr Nathaniel J Szewczyk

  68. The Utility of C. Elegans for Space Exploration

    Article • September 2006, American Institute of Aeronautics and Astronautics (AIAA)

    Dr Nathaniel J Szewczyk

  69. Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight

    Article • Journal of Experimental Biology, September 2006, The Company of Biologists

    Dr Nathaniel J Szewczyk

  70. Decreased expression of myogenic transcription factors and myosin heavy chains in Caenorhabditis elegans muscles developed during spaceflight

    Article • Journal of Experimental Biology, August 2006, The Company of Biologists

    Dr Nathaniel J Szewczyk

  71. Caenorhabditis elegans Survives Atmospheric Breakup of STS-107, Space Shuttle Columbia

    Article • Astrobiology, December 2005, Mary Ann Liebert Inc

    Dr Nathaniel J Szewczyk

  72. Signal-transduction networks and the regulation of muscle protein degradation

    Article • The International Journal of Biochemistry & Cell Biology, October 2005, Elsevier

    Dr Nathaniel J Szewczyk

  73. Checkpoint and physiological apoptosis in germ cells proceeds normally in spaceflown Caenorhabditis elegans

    Article • APOPTOSIS, October 2005, Springer Science + Business Media

    Dr Nathaniel J Szewczyk

  74. Surviving Atmospheric Spacecraft Breakup

    Article • Wilderness and Environmental Medicine, March 2005, Elsevier

    Dr Nathaniel J Szewczyk

  75. Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans

    Article • The EMBO Journal, October 2003, Wiley

    Dr Nathaniel J Szewczyk

  76. Article • BMC Biotechnology, January 2003, Springer Science + Business Media

    Dr Nathaniel J Szewczyk

  77. Activation of Ras and the Mitogen-Activated Protein Kinase Pathway Promotes Protein Degradation in Muscle Cells of Caenorhabditis elegans

    Article • Molecular and Cellular Biology, June 2002, ASM Journals

    Dr Nathaniel J Szewczyk

  78. Transgene‐coded chimeric proteins as reporters of intracellular proteolysis: Starvation‐induced catabolism of a lacZ fusion protein in muscle cells of Caenorhabditis elegans

    Article • Journal of Cellular Biochemistry, October 1997, Wiley

    Dr Nathaniel J Szewczyk

  79. Transgene-coded chimeric proteins as reporters of intracellular proteolysis: Starvation-induced catabolism of alacZ fusion protein in muscle cells ofCaenorhabditis elegans

    Article • Journal of Cellular Biochemistry, October 1997, Wiley

    Dr Nathaniel J Szewczyk