Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans muscle

  • Muscle functional phosphatome
  • Susann Lehmann, Joseph J. Bass, Thomas F. Barratt, Mohammed Z. Ali, Nathaniel J. Szewczyk
  • Journal of Cachexia Sarcopenia and Muscle, May 2017, Wiley
  • DOI: 10.1002/jcsm.12196

Phosphatases that regulate muscle protein degradation

What is it about?

This paper describes genetic screens in the worm C. elegans that attempt to identify what phosphatases regulate muscle.

Why is it important?

Muscle loss is an important problem in the clinic both for people as they naturally age (a growing problem) and in a diverse set of clinical diagnoses. Unfortunately, we do not have good pharmacologic interventions to prevent muscle loss. This gap in knowledge is largely down to lack of molecular understanding, and therefore ability to target, mechanisms of loss of muscle mass.


Dr Nathaniel J Szewczyk
University of Nottingham

It was cool to describe the first set of phosphatase that appear to regulate muscle, even if it will take many years for this work to be appreciated (if at all).

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The following have contributed to this page: Dr Nathaniel J Szewczyk and Dr Susann Lehmann