All Stories

  1. Identification and Characterization of Efflux Transporters That Modulate the Subtoxic Disposition of Diclofenac and Its Metabolites

    Article • Drug Metabolism and Disposition, August 2019, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  2. Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics

    Article • Current Medicinal Chemistry, May 2019, Bentham Science Publishers

    Dr. José E Manautou

  3. The Role of Cyclic Nucleotides in Compensatory Hepatocyte Proliferation

    Article • Current Drug Metabolism, February 2018, Bentham Science Publishers

    Dr. José E Manautou, Dr Li Wang

  4. The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2)

    Article • Toxicology and Applied Pharmacology, August 2016, Elsevier

    Dr. José E Manautou

  5. From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective

    Article • F1000Research, July 2016, Faculty of 1000, Ltd.

    Dr. José E Manautou

  6. Preventing Liver Toxicity

    Article • F1000Research, July 2016, Faculty of 1000, Ltd.

    Dr. José E Manautou

  7. Acetaminophen Attenuates House Dust Mite-Induced Allergic Airway Disease in Mice

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  8. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity

    Article • Pharmacological Research, July 2016, Elsevier

    Dr. José E Manautou

  9. Reduced in vivo toxicity of doxorubicin by encapsulation in cholesterol-containing self-assembled nanoparticles

    Article • Pharmacological Research, May 2016, Elsevier

    Dr. José E Manautou

  10. Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, April 2016, Elsevier

    Dr. José E Manautou

  11. Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3) gene expression in HepG2 cells

    Article • Toxicology in Vitro, March 2016, Elsevier

    Dr. José E Manautou, Ronald N. Hines

  12. Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet

    Article • Molecular Nutrition & Food Research, February 2016, Wiley

    Dr. José E Manautou

  13. Elucidation of the Mechanisms through Which the Reactive Metabolite Diclofenac Acyl Glucuronide Can Mediate Toxicity

    Article • Journal of Pharmacology and Experimental Therapeutics, February 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  14. Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice

    Article • Environmental Health Perspectives, October 2015, Environmental Health Perspectives

    Dr. José E Manautou

  15. Identifying and prioritising emerging issues in human & environmental sciences

    Article • Toxicology Letters, October 2015, Elsevier

    Dr. José E Manautou

  16. Antioxidant fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr. induce nuclear translocation of Nrf2 in HC-04 cells

    Article • Cell Stress and Chaperones, August 2015, Springer Science + Business Media

    Dr. José E Manautou

  17. Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions

    Article • Current Medicinal Chemistry, July 2015, Bentham Science Publishers

    Dr. José E Manautou

  18. Multidrug Resistance-Associated Protein 3 Plays an Important Role in Protection against Acute Toxicity of Diclofenac

    Article • Drug Metabolism and Disposition, April 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  19. Role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the transcriptional regulation of brain ABC transporters during acute acetaminophen (APAP) intoxication in mice

    Article • Biochemical Pharmacology, April 2015, Elsevier

    Dr. José E Manautou

  20. Altered Regulation of Hepatic Efflux Transporters Disrupts Acetaminophen Disposition in Pediatric Nonalcoholic Steatohepatitis

    Article • Drug Metabolism and Disposition, March 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  21. Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice

    Article • Toxicology, November 2014, Elsevier

    Dr. José E Manautou

  22. Is Nuclear Factor Erythroid 2–Related Factor 2 Responsible for Sex Differences in Susceptibility to Acetaminophen-Induced Hepatotoxicity in Mice?

    Article • Drug Metabolism and Disposition, August 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  23. Tolerance to Acetaminophen Hepatotoxicity in the Mouse Model of Autoprotection Is Associated with Induction of Flavin-Containing Monooxygenase-3 (FMO3) in Hepatocytes

    Article • Toxicological Sciences, June 2014, Oxford University Press (OUP)

    Dr. José E Manautou, Ronald N. Hines

  24. Transgenic Expression of the Human MRP2 Transporter Reduces Cisplatin Accumulation and Nephrotoxicity in Mrp2-Null Mice

    Article • American Journal Of Pathology, May 2014, Elsevier

    Dr. José E Manautou

  25. ChemInform Abstract: Rubescins A (I), B (II) and C (III): New Havanensin Type Limonoids from Root Bark of Trichilia rubescens (Meliaceae).

    Article • ChemInform, April 2014, Wiley

    Dr. José E Manautou

  26. Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection)

    Article • Toxicology and Applied Pharmacology, January 2014, Elsevier

    Dr. José E Manautou

  27. CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis

    Article • Toxicology and Applied Pharmacology, January 2014, Elsevier

    Dr. José E Manautou

  28. Cholesterol-Secreting and Statin-Responsive Hepatocytes from Human ES and iPS Cells to Model Hepatic Involvement in Cardiovascular Health

    Article • PLoS ONE, July 2013, PLOS

    Dr. José E Manautou

  29. Acute glutathione depletion induces hepatic methylglyoxal accumulation by impairing its detoxification to d-lactate

    Article • Experimental Biology and Medicine, April 2013, SAGE Publications

    Dr. José E Manautou

  30. Rubescins A, B and C: New Havanensin Type Limonoids from Root Bark of Trichilia rubescens (Meliaceae)

    Article • Chemical and Pharmaceutical Bulletin, January 2013, Pharmaceutical Society of Japan

    Dr. José E Manautou

  31. Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease

    Article • Drug Metabolism and Disposition, December 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  32. Nrf2: A Potential Target for New Therapeutics in Liver Disease

    Article • Clinical Pharmacology & Therapeutics, August 2012, Nature

    Dr. José E Manautou

  33. Drug Transporters

    Article • Current Protocols in Toxicology, May 2012, Wiley

    Dr. José E Manautou

  34. Molecular mechanisms underlying chemical liver injury

    Article • Expert Reviews in Molecular Medicine, February 2012, Cambridge University Press

    Dr. José E Manautou

  35. Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1

    Article • Journal of Biochemical and Molecular Toxicology, May 2011, Wiley

    Dr. José E Manautou

  36. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

    Article • The Journal of Nutritional Biochemistry, April 2011, Elsevier

    Dr Richard S Bruno, Dr. José E Manautou

  37. Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  38. Vanin-1 deficient mice have enhanced susceptibility to acetaminophen hepatotoxicity

    Article • Toxicology Letters, July 2010, Elsevier

    Dr. José E Manautou

  39. Regulation of hepatic ABCC transporters by xenobiotics and in disease states

    Article • Drug Metabolism Reviews, March 2010, Taylor & Francis

    Dr. José E Manautou

  40. Regulation of Hepatobiliary Transporters during Liver Injury

    Article • January 2010, Elsevier

    Dr. José E Manautou

  41. Effect of allyl alcohol on hepatic transporter expression: Zonal patterns of expression and role of Kupffer cell function

    Article • Toxicology and Applied Pharmacology, April 2009, Elsevier

    Dr. José E Manautou

  42. Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity

    Article • Toxicology and Applied Pharmacology, September 2008, Elsevier

    Dr. José E Manautou

  43. Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment

    Article • Toxicology, September 2008, Elsevier

    Dr. José E Manautou

  44. Nrf2- and PPAR -Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid

    Article • Toxicological Sciences, August 2008, Oxford University Press (OUP)

    Dr. José E Manautou

  45. Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

    Article • AJP Gastrointestinal and Liver Physiology, June 2008, American Physiological Society

    Dr. José E Manautou

  46. Drug-Metabolizing Enzyme and Transporter Expression in a Mouse Model of Diabetes and Obesity

    Article • Molecular Pharmaceutics, February 2008, American Chemical Society (ACS)

    Dr. José E Manautou

  47. Renal and Hepatic Transporter Expression in Type 2 Diabetic Rats

    Article • Drug Metabolism Letters, January 2008, Bentham Science Publishers

    Dr. José E Manautou

  48. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

    Article • Toxicology and Applied Pharmacology, January 2008, Elsevier

    Dr. José E Manautou

  49. Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes

    Article • Toxicological Sciences, December 2007, Oxford University Press (OUP)

    Dr. José E Manautou

  50. Influence of Acetaminophen Vehicle on Regulation of Transporter Gene Expression During Hepatotoxicity

    Article • Journal of Toxicology and Environmental Health Part A, September 2007, Taylor & Francis

    Dr. José E Manautou

  51. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway

    Article • Hepatology, August 2007, Wiley

    Dr. José E Manautou

  52. Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease

    Article • Drug Metabolism and Disposition, July 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  53. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate☆

    Article • Toxicology and Applied Pharmacology, July 2007, Elsevier

    Dr. José E Manautou

  54. Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases

    Article • Drug Metabolism and Disposition, July 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. José E Manautou

  55. Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease

    Article • Toxicologic Pathology, June 2007, SAGE Publications

    Dr. José E Manautou

  56. Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 2007, Elsevier

    Dr. José E Manautou

  57. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen

    Article • Toxicology, February 2007, Elsevier

    Dr. José E Manautou

  58. Cholestasis induced by model organic anions protects from acetaminophen hepatotoxicity in male CD-1 mice

    Article • Toxicology Letters, January 2006, Elsevier

    Dr. José E Manautou

  59. Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis

    Article • Cell Stress and Chaperones, January 2006, Springer Science + Business Media

    Dr. José E Manautou

  60. Transport deficient (TR−) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity

    Article • Biochemical Pharmacology, December 2005, Elsevier

    Dr. José E Manautou

  61. Altered disposition of acetaminophen in mice with a disruption of theMrp3 gene

    Article • Hepatology, January 2005, Wiley

    Dr. José E Manautou

  62. The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding

    Article • Toxicology, October 2004, Elsevier

    Dr. José E Manautou

  63. Collection of Bile and Urine Samples for Determining the Urinary and Hepatobiliary Disposition of Xenobiotics in Mice

    Article • Current Protocols in Toxicology, January 2004, Wiley

    Dr. José E Manautou

  64. CAR inhibitors: new line of treatment for APAP poisoning?

    Article • Journal of Hepatology, August 2003, Elsevier

    Dr. José E Manautou

  65. Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: Role of catalase induction

    Article • Journal of Biochemical and Molecular Toxicology, January 2002, Wiley

    Dr. José E Manautou

  66. Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green

    Article • Food and Chemical Toxicology, March 2001, Elsevier

    Dr. José E Manautou

  67. Effects of clofibrate and indocyanine green on the hepatobiliary disposition of acetaminophen and its metabolites in male CD-1 mice

    Article • Xenobiotica, January 2000, Taylor & Francis

    Dr. José E Manautou

  68. In vivo covalent binding of acetaminophen to canalicular and basolateral membrane proteins in mouse liver

    Article • Toxicology Letters, July 1998, Elsevier

    Dr. José E Manautou

  69. Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice1Presented in part at the at the 35th Annual Meeting of the Society of Toxicology, Anaheim, CA, 1996.1

    Article • Toxicology, May 1998, Elsevier

    Dr. José E Manautou

  70. Protection by Clofibrate against Acetaminophen Hepatotoxicity in Male CD-1 Mice Is Associated with an Early Increase in Biliary Concentration of Acetaminophen–Glutathione Adducts

    Article • Toxicology and Applied Pharmacology, September 1996, Elsevier

    Dr. José E Manautou

  71. Protection against Acetaminophen Hepatotoxicity by a Single Dose of Clofibrate: Effects on Selective Protein Arylation and Glutathione Depletion

    Article • Fundamental and Applied Toxicology, February 1996, Elsevier

    Dr. José E Manautou

  72. Protection against Acetaminophen Hepatotoxicity by a Single Dose of Clofibrate: Effects on Selective Protein Arylation and Glutathione Depletion

    Article • Toxicological Sciences, January 1996, Oxford University Press (OUP)

    Dr. José E Manautou

  73. Evidence Suggesting the 58-kDa Acetaminophen Binding Protein Is a Preferential Target for Acetaminophen Electrophile

    Article • Toxicological Sciences, January 1996, Oxford University Press (OUP)

    Dr. José E Manautou

  74. Evidence for common binding of acetaminophen and bromobenzene to the 58‐kda acetaminophen‐binding protein

    Article • Journal of Toxicology and Environmental Health, November 1995, Taylor & Francis

    Dr. José E Manautou

  75. Clofibrate Pretreatment Diminishes Acetaminophen′s Selective Covalent Binding and Hepatotoxicity

    Article • Toxicology and Applied Pharmacology, December 1994, Elsevier

    Dr. José E Manautou

  76. Oxidative and non-oxidative metabolism of ethanol by the rabbit lung

    Article • Toxicology Letters, August 1992, Elsevier

    Dr. José E Manautou

  77. Comparison of rat pulmonary and hepatic cytosolic alcohol dehydrogenase activities

    Article • Journal of Toxicology and Environmental Health, January 1992, Taylor & Francis

    Dr. José E Manautou

  78. Comparison of pulmonary and hepatic glucuronidation and sulphation of ethanol in rat and rabbit in vitro

    Article • Xenobiotica, January 1992, Taylor & Francis

    Dr. José E Manautou

  79. Ethanol-induced fatty acid ethyl ester formation in vivo and in vitro in rat lung

    Article • Toxicology, January 1991, Elsevier

    Dr. José E Manautou

  80. Effect of the intrauterine contraceptive device upon the biochemical composition of human endometrium

    Article • American Journal of Obstetrics and Gynecology, September 1972, Elsevier

    Dr. José E Manautou