All Stories

  1. Machine learning classifies cancer

    Article • Nature, March 2018, Springer Science + Business Media

    Dr Stephen Yip

  2. A case of primary central nervous system lymphoma arising at the site of remote herpes encephalitis.

    Article • World Neurosurgery, January 2018, Elsevier

    Dr Stephen Yip

  3. Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer

    Article • Clinical Cancer Research, December 2017, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  4. The driver landscape of sporadic chordoma

    Article • Nature Communications, October 2017, Nature

    Dr Stephen Yip

  5. Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer

    Article • Annals of Oncology, September 2017, Oxford University Press (OUP)

    Dr Stephen Yip

  6. Detection and genomic characterization of a mammary-like adenocarcinoma

    Article • Molecular Case Studies, September 2017, Cold Spring Harbor Laboratory Press

    Dr Stephen Yip

  7. Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

    Article • Acta Neuropathologica, July 2017, Springer Science + Business Media

    Dr Stephen Yip

  8. Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2 :c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma

    Article • Molecular Case Studies, May 2017, Cold Spring Harbor Laboratory Press

    Dr Stephen Yip

  9. Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua (CIC) loss to activation of the MAPK signalling cascade

    Article • The Journal of Pathology, April 2017, Wiley

    Dr Stephen Yip

  10. The cost and cost trajectory of whole-genome analysis guiding treatment of patients with advanced cancers

    Article • Molecular Genetics & Genomic Medicine, March 2017, Wiley

    Dr Stephen Yip

  11. Stem Cell Biology

    Article • January 2017, Elsevier

    Dr Stephen Yip

  12. Personalized oncogenomics in the management of gastrointestinal carcinomas— early experiences from a pilot study

    Article • Current Oncology, December 2016, MultiMed Inc.

    Dr Stephen Yip

  13. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

    Article • Cancer Cell, December 2016, Elsevier

    Dr Stephen Yip

  14. Epstein-Barr virus associated primary intracranial leiomyoma in a patient with human immunodeficiency virus

    Article • Clinical Neuropathology, November 2016, Dustri-Verlgag Dr. Karl Feistle

    Dr Stephen Yip

  15. The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery

    Article • Cell, November 2016, Elsevier

    Dr Stephen Yip , Dr Christoph Bock

  16. Spinal column chordoma: prognostic significance of clinical variables andT (brachyury) gene SNP rs2305089 for local recurrence and overall survival

    Article • Neuro-Oncology, September 2016, Oxford University Press (OUP)

    Dr Stephen Yip

  17. Investigation of PD-L1 Biomarker Testing Methods for PD-1 Axis Inhibition in Non-squamous Non-small Cell Lung Cancer

    Article • Journal of Histochemistry & Cytochemistry, September 2016, Journal of Histochemistry & Cytochemistry (The Histochemical Society)

    Dr Stephen Yip

  18. ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors

    Article • The American Journal of Surgical Pathology, August 2016, Wolters Kluwer Health

    Dr Stephen Yip

  19. Abstract 5226: Genomic analysis of pancreatic ductal adenocarcinoma in a patient with MUTYH-associated polyposis

    Article • Cancer Research, July 2016, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  20. Abstract 2631: Restrictions on access to systemic therapy limit the application of whole genome sequencing in clinical care

    Article • Cancer Research, July 2016, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  21. Abstract PR02: Integrated genomic analysis of a recurrent ghost cell odontogenic carcinoma

    Article • Clinical Cancer Research, January 2016, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  22. Panencephalopathic Creutzfeldt-Jakob disease

    Article • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, December 2015, Cambridge University Press

    Dr Stephen Yip

  23. Paternal uniparental disomy 11p15.5 in the pancreatic nodule of an infant with Costello syndrome: Shared mechanism for hyperinsulinemic hypoglycemia in neonates with Costello and Beckwith-Wiedemann syndrome and somatic loss of heterozygosity in Costello s

    Article • American Journal of Medical Genetics Part A, November 2015, Wiley

    Dr Stephen Yip

  24. Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes

    Article • Journal of Molecular Diagnostics, November 2015, Elsevier

    Dr Stephen Yip

  25. Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers

    Article • Molecular Case Studies, September 2015, Cold Spring Harbor Laboratory Press

    Dr Stephen Yip

  26. Integrative genomic analysis of ghost cell odontogenic carcinoma

    Article • Oral Oncology, September 2015, Elsevier

    Dr Stephen Yip

  27. Abstract 1122: Personalized oncogenomics in advanced stage breast cancer

    Article • Cancer Research, August 2015, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  28. Prognostic Significance of T Gene SNP s2305089 in Individuals with Spinal Column Chordoma

    Article • Global Spine Journal, May 2015, Thieme Publishing Group

    Dr Stephen Yip

  29. Novel targeted therapies in chordoma: an update

    Article • Therapeutics and Clinical Risk Management, May 2015, Dove Medical Press

    Dr Salvatore Di Maio, Dr Stephen Yip , Skull base and cerebrovascular fellow Gmaan Alzhrani, Neurosurgeon FRCSC Fahad FA Alotaibi

  30. Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis

    Article • The Lancet Oncology, May 2015, Elsevier

    Dr Stephen Yip

  31. Fatal Congenital Hypertrophic Cardiomyopathy and a Pancreatic Nodule Morphologically Identical to Focal Lesion of Congenital Hyperinsulinism in an Infant with Costello Syndrome: Case Report and Review of the Literature

    Article • Pediatric and Developmental Pathology, May 2015, Society for Pediatric Pathology (SPP)

    Dr Stephen Yip

  32. 35-Year-Old Man with Lytic Skull Lesion

    Article • Brain Pathology, April 2015, Wiley

    Dr Stephen Yip

  33. Personalized Oncogenomics: Clinical Experience with Malignant Peritoneal Mesothelioma Using Whole Genome Sequencing

    Article • PLoS ONE, March 2015, PLOS

    Dr Stephen Yip

  34. Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma

    Article • Clinical Cancer Research, January 2015, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  35. EZH2 expression is a prognostic factor in childhood intracranial ependymoma: A Canadian Pediatric Brain Tumor Consortium study

    Article • Cancer, January 2015, Wiley

    Dr Stephen Yip

  36. Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas

    Article • BMC Cancer, January 2015, Springer Science + Business Media

    Dr Stephen Yip

  37. Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas

    Article • BMC Cancer, December 2014, Springer Science + Business Media

    Dr Stephen Yip

  38. The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience

    Article • Child s Nervous System, November 2014, Springer Science + Business Media

    Dr Stephen Yip

  39. Oligodendroglial Tumors

    Article • November 2014, Springer Science + Business Media

    Dr Stephen Yip

  40. Abstract 5340: Bioinformatic analyses approaches for personalized oncogenomics

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  41. Abstract 4283: Whole genome sequencing is superior to cancer panels to aid in decision-making in patients with advanced malignancies

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  42. Abstract 4704: Prognostic significance of T gene SNP s2305089 in individuals with spinal column chordoma

    Article • Cancer Research, September 2014, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  43. Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity

    Article • Oncotarget, September 2014, Impact Journals, LLC

    Dr Stephen Yip

  44. Somatic mosaicism for the p.His1047Arg mutation in PIK3CA in a girl with mesenteric lipomatosis

    Article • American Journal of Medical Genetics Part A, June 2014, Wiley

    Dr Stephen Yip

  45. Diagnostic Value of Next-Generation Sequencing in an Unusual Sphenoid Tumor

    Article • The Oncologist, May 2014, Alphamed Press

    Dr Stephen Yip

  46. Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

    Article • Nature Genetics, April 2014, Nature

    Dr Stephen Yip

  47. Deep Sequencing Identifies IDH1 R132S Mutation in Adult Medulloblastoma

    Article • Journal of Clinical Oncology, March 2014, American Society of Clinical Oncology (ASCO)

    Dr Stephen Yip

  48. Oncogenic codon 13 NRAS mutation in a primary mesenchymal brain neoplasm and nevus of a child with neurocutaneous melanosis

    Article • Acta Neuropathologica Communications, January 2014, Springer Science + Business Media

    Dr Stephen Yip

  49. Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) Low-grade Glioma Research Workshop

    Article • Neuro-Oncology, December 2013, Oxford University Press (OUP)

    Dr Stephen Yip

  50. Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profiling

    Article • The Journal of Pathology, August 2013, Wiley

    Dr Stephen Yip

  51. Abstract LB-173: Genome analysis informs chemotherapy decision-making in patients with advanced malignancies.

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Dr Stephen Yip

  52. Letter to the Editor: Cribriform neuroepithelial tumor or atypical teratoid/rhabdoid tumor?

    Article • Journal of Neurosurgery Pediatrics, April 2013, Journal of Neurosurgery Publishing Group (JNSPG)

    Dr Stephen Yip

  53. Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma

    Article • Cell, February 2013, Elsevier

    Dr Stephen Yip

  54. Array CGH in Brain Tumors

    Article • January 2013, Springer Science + Business Media

    Dr Stephen Yip

  55. Converging paths to progress for skull base chordoma: Review of current therapy and future molecular targets

    Article • Surgical Neurology International, January 2013, Medknow

    Dr Stephen Yip

  56. DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma

    Article • Annals of Neurology, June 2012, Wiley

    Dr Stephen Yip

  57. Polo‐Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice

    Article • Stem Cells, May 2012, Oxford University Press (OUP)

    Dr Stephen Yip , Hiroaki Wakimoto

  58. The Potential and Challenges of siRNA-Based Targeted Therapy for Treatment of Patients with Glioblastoma

    Article • April 2012, IntechOpen

    Dr Stephen Yip

  59. Stem Cells in Brain Tumour Development and Therapy- Two-Sides of the Same Coin

    Article • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, March 2012, Cambridge University Press

    Dr Stephen Yip

  60. Nucleic acid quantity and quality from paraffin blocks: Defining optimal fixation, processing and DNA/RNA extraction techniques

    Article • Experimental and Molecular Pathology, February 2012, Elsevier

    Dr Stephen Yip

  61. Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers

    Article • The Journal of Pathology, November 2011, Wiley

    Mr Shaun Dunn Jackman, Dr Stephen Yip

  62. Low-grade fibromyxoid sarcoma of the perineum with heterotopic ossification: case report and review of the literature

    Article • Human Pathology, November 2011, Elsevier

    Dr Stephen Yip

  63. Stem Cell Biology

    Article • January 2011, Elsevier

    Dr Stephen Yip

  64. ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

    Article • New England Journal of Medicine, October 2010, New England Journal of Medicine (NEJM/MMS)

    Dr Stephen Yip

  65. Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers

    Article • The Lancet Neurology, July 2010, Elsevier

    Dr Stephen Yip

  66. Optical Imaging of Cancer: Neuro-oncologic Applications

    Article • July 2009, Springer Science + Business Media

    Dr Stephen Yip

  67. Molecular Diagnostic Testing in Malignant Gliomas: A Practical Update on Predictive Markers

    Article • Journal of Neuropathology & Experimental Neurology, January 2008, Oxford University Press (OUP)

    Dr Stephen Yip

  68. Stem Cells for Targeting CNS Malignancy

    Article • January 2005, Karger Publishers

    Dr Stephen Yip

  69. Stem Cell Biology

    Article • January 2004, Elsevier

    Dr Stephen Yip

  70. Neural Stem Cell Biology May Be Well Suited for Improving Brain Tumor Therapies

    Article • The Cancer Journal, May 2003, Wolters Kluwer Health

    Dr Stephen Yip

  71. Selective elimination of malignant stem cells using photosensitizers followed by light treatment

    Article • Stem Cells, January 1995, Wiley

    Dr Stephen Yip

  72. Immunological effects of photodynamic therapy

    Article • July 1990, SPIE

    Dr Stephen Yip