All Stories

  1. Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells

    Article • Nature Communications, November 2025, Springer Science + Business Media

    Zhenguo Wu

  2. TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation

    Article • Proceedings of the National Academy of Sciences, November 2023, Proceedings of the National Academy of Sciences

    Yusong Guo, Zhenguo Wu

  3. Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration

    Article • Science Advances, October 2023, American Association for the Advancement of Science

    Zhenguo Wu

  4. Single-cell chromatin accessibility profiling reveals a self-renewing muscle satellite cell state

    Article • Journal of Cell Biology, June 2023, Rockefeller University Press

    Zhenguo Wu

  5. Cell fate determining molecular switches and signaling pathways in Pax7-expressing somitic mesoderm

    Article • Cell Discovery, June 2022, Springer Science + Business Media

    Zhenguo Wu

  6. Elevated extracellular adenosine under diabetic conditions impairs adult muscle stem cells.

    Article • Cell Reports, May 2022, Elsevier

    Zhenguo Wu

  7. A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite Cells

    Article • International Journal of Molecular Sciences, February 2022, MDPI AG

    Zhenguo Wu

  8. Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid

    Article • Journal of Biological Chemistry, October 2021, Elsevier

    Zhenguo Wu

  9. A new regulator for a key cell growth checkpoint during activation of the dormant muscle stem cells

    Article • Proceedings of the National Academy of Sciences, March 2021, Proceedings of the National Academy of Sciences

    Zhenguo Wu

  10. A long noncoding RNA, LncMyoD , modulates chromatin accessibility to regulate muscle stem cell myogenic lineage progression

    Article • Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences

    Tom Cheung, Zhenguo Wu

  11. In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label‐free multiphoton redox and fluorescence lifetime microscopy

    Article • Journal of Biophotonics, November 2019, Wiley

    Zhenguo Wu

  12. YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells

    Article • The EMBO Journal, April 2019, EMBO

    Huating Wang, Zhenguo Wu

  13. Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds

    Article • Nature Communications, January 2019, Springer Science + Business Media

    Zhenguo Wu

  14. In vivo metabolic imaging and monitoring of brown and beige fat

    Article • Journal of Biophotonics, April 2018, Wiley

    SICONG HE, Zhenguo Wu

  15. Activation of PI3K wakes up the dormant adult muscle stem cells upon muscle injury

    Article • The EMBO Journal, March 2018, EMBO

    Zhenguo Wu

  16. In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues

    Article • Biomedical Optics Express, January 2018, Optical Society of America (OSA)

    Zhenguo Wu

  17. A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes

    Article • Developmental Cell, May 2017, Elsevier

    Zhenguo Wu

  18. STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration

    Article • Cell Reports, August 2016, Elsevier

    Zhenguo Wu

  19. Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signaling

    Article • Oncogene, February 2016, Springer Science + Business Media

    Zhenguo Wu

  20. MicroRNAs 99b-5p/100-5p Regulated by Endoplasmic Reticulum Stress are Involved in Abeta-Induced Pathologies

    Article • Frontiers in Aging Neuroscience, November 2015, Frontiers

    Zhenguo Wu

  21. A Universal and Facile Approach for the Formation of a Protein Hydrogel for 3D Cell Encapsulation

    Article • Advanced Functional Materials, September 2015, Wiley

    Zhenguo Wu

  22. Cdk5-Dependent Mst3 Phosphorylation and Activity Regulate Neuronal Migration through RhoA Inhibition

    Article • Journal of Neuroscience, May 2014, Society for Neuroscience

    Zhenguo Wu

  23. miR-203, a Tumor Suppressor Frequently Down-regulated by Promoter Hypermethylation in Rhabdomyosarcoma

    Article • Journal of Biological Chemistry, January 2014, Elsevier

    Zhenguo Wu

  24. Label-free multimodal nonlinear optical microscopy reveals fundamental insights of skeletal muscle development

    Article • Biomedical Optics Express, December 2013, Optical Society of America (OSA)

    Zhenguo Wu

  25. Keratin K18 Increases Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Surface Expression by Binding to Its C-terminal Hydrophobic Patch

    Article • Journal of Biological Chemistry, November 2012, Elsevier

    Zhenguo Wu

  26. Pax3/7BP Is a Pax7- and Pax3-Binding Protein that Regulates the Proliferation of Muscle Precursor Cells by an Epigenetic Mechanism

    Article • Cell Stem Cell, August 2012, Elsevier

    Zhenguo Wu

  27. Loss of STAT1 in Bone Marrow-Derived Cells Accelerates Skeletal Muscle Regeneration

    Article • PLOS One, May 2012, PLOS

    Zhenguo Wu

  28. TRAF6 Promotes Myogenic Differentiation via the TAK1/p38 Mitogen-Activated Protein Kinase and Akt Pathways

    Article • PLOS One, April 2012, PLOS

    Zhenguo Wu

  29. A continuous spectrophotometric assay for mitogen-activated protein kinase kinases

    Article • Analytical Biochemistry, February 2012, Elsevier

    Zhenguo Wu

  30. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors

    Article • Journal of Cell Science, January 2012, The Company of Biologists

    Zhenguo Wu

  31. Signal‐dependent incorporation of MyoD–BAF60c into Brg1‐based SWI/SNF chromatin‐remodelling complex

    Article • The EMBO Journal, November 2011, Springer Science + Business Media

    Zhenguo Wu

  32. Expression of Gαz in C2C12 cells restrains myogenic differentiation

    Article • Cellular Signalling, February 2011, Elsevier

    Zhenguo Wu

  33. Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding

    Article • Proceedings of the National Academy of Sciences, November 2010, Proceedings of the National Academy of Sciences

    Zhenguo Wu

  34. Oncostatin M inhibits myoblast differentiation and regulates muscle regeneration

    Article • BDJ, October 2010, Springer Science + Business Media

    Zhenguo Wu

  35. Tyk2/STAT3 Signaling Mediates β-Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease

    Article • Journal of Neuroscience, May 2010, Society for Neuroscience

    Dr Kwok-On Lai, Zhenguo Wu

  36. Role of mitogen‐activated protein kinase in Zn‐BC‐AM PDT‐induced apoptosis in nasopharyngeal carcinoma cells

    Article • Cell Biochemistry and Function, March 2010, Wiley

    Zhenguo Wu

  37. Nerve Growth Factor-Induced Differentiation of PC12 Cells Is Accompanied by Elevated Adenylyl Cyclase Activity

    Article • Neurosignals, January 2010, Karger Publishers

    Zhenguo Wu

  38. SOCS1, SOCS3, and PIAS1 Promote Myogenic Differentiation by Inhibiting the Leukemia Inhibitory Factor-Induced JAK1/STAT1/STAT3 Pathway

    Article • Molecular and Cellular Biology, July 2009, ASM Journals

    Zhenguo Wu

  39. Differential and Synergistic Effect of Nerve Growth Factor and cAMP on the Regulation of Early Response Genes during Neuronal Differentiation

    Article • Neurosignals, January 2009, Karger Publishers

    Zhenguo Wu

  40. JAK2/STAT2/STAT3 Are Required for Myogenic Differentiation

    Article • Journal of Biological Chemistry, December 2008, Elsevier

    Zhenguo Wu

  41. Involvement of the p38 Mitogen-activated Protein Kinase α, β, and γ Isoforms in Myogenic Differentiation

    Article • Molecular Biology of the Cell, April 2008, American Society for Cell Biology (ASCB)

    Zhenguo Wu

  42. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma

    Article • Hepatology, February 2008, Wolters Kluwer Health

    Zhenguo Wu

  43. JAK1–STAT1–STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts

    Article • Journal of Cell Biology, October 2007, Rockefeller University Press

    Zhenguo Wu

  44. BS69 is involved in cellular senescence through the p53–p21Cip1 pathway

    Article • EMBO Reports, August 2007, Springer Science + Business Media

    Zhenguo Wu

  45. Sequential Recruitment of PCAF and BRG1 Contributes to Myogenin Activation in 12-O-Tetradecanoylphorbol-13-acetate-induced Early Differentiation of Rhabdomyosarcoma-derived Cells

    Article • Journal of Biological Chemistry, June 2007, Elsevier

    Zhenguo Wu

  46. Myostatin Induces Cyclin D1 Degradation to Cause Cell Cycle Arrest through a Phosphatidylinositol 3-Kinase/AKT/GSK-3β Pathway and Is Antagonized by Insulin-like Growth Factor 1

    Article • Journal of Biological Chemistry, February 2007, Elsevier

    Zhenguo Wu

  47. Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

    Article • FEBS Letters, December 2006, Wiley

    Zhenguo Wu

  48. Latent membrane protein 1 suppresses RASSF1A expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells

    Article • Oncogene, November 2006, Springer Science + Business Media

    Zhenguo Wu

  49. Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase

    Article • International Journal of Cancer, July 2006, Wiley

    Zhenguo Wu

  50. BS69, a Specific Adaptor in the Latent Membrane Protein 1-Mediated c-Jun N-Terminal Kinase Pathway

    Article • Molecular and Cellular Biology, January 2006, ASM Journals

    Zhenguo Wu

  51. The C-terminal Activating Region 2 of the Epstein-Barr Virus-encoded Latent Membrane Protein 1 Activates NF-κB through TRAF6 and TAK1

    Article • Journal of Biological Chemistry, January 2006, Elsevier

    Zhenguo Wu

  52. Myocyte Enhancer Factor 2 Acetylation by p300 Enhances Its DNA Binding Activity, Transcriptional Activity, and Myogenic Differentiation

    Article • Molecular and Cellular Biology, May 2005, ASM Journals

    Zhenguo Wu

  53. Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome

    Article • American Review of Respiratory Disease, April 2005, American Thoracic Society

    Zhenguo Wu

  54. The 8-kDa Dynein Light Chain Binds to p53-binding Protein 1 and Mediates DNA Damage-induced p53 Nuclear Accumulation

    Article • Journal of Biological Chemistry, March 2005, Elsevier

    Zhenguo Wu

  55. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

    Article • The EMBO Journal, November 2004, Wiley

    Dr. Shu-Yong Lin, Zhenguo Wu

  56. p150Glued, Dynein, and Microtubules Are Specifically Required for Activation of MKK3/6 and p38 MAPKs

    Article • Journal of Biological Chemistry, October 2004, Elsevier

    Zhenguo Wu

  57. Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation

    Article • Journal of Cell Science, June 2004, The Company of Biologists

    Zhenguo Wu

  58. Elucidation of the c-Jun N-Terminal Kinase Pathway Mediated by Epstein-Barr Virus-Encoded Latent Membrane Protein 1

    Article • Molecular and Cellular Biology, January 2004, ASM Journals

    Zhenguo Wu

  59. The involvement of calcineurin in acetylcholine receptor redistribution in muscle

    Article • Molecular and Cellular Neuroscience, August 2003, Elsevier

    Zhenguo Wu

  60. Functional Characterization of an Amino-terminal Region of HDAC4 That Possesses MEF2 Binding and Transcriptional Repressive Activity

    Article • Journal of Biological Chemistry, June 2003, Elsevier

    Zhenguo Wu

  61. Positive Feedback Regulation between Akt2 and MyoD during Muscle Differentiation

    Article • Journal of Biological Chemistry, June 2002, Elsevier

    Zhenguo Wu

  62. p38 Mitogen-activated Protein Kinase-, Calcium-Calmodulin–dependent Protein Kinase-, and Calcineurin-mediated Signaling Pathways Transcriptionally Regulate Myogenin Expression

    Article • Molecular Biology of the Cell, June 2002, American Society for Cell Biology (ASCB)

    Zhenguo Wu

  63. The Insulin-like Growth Factor-Phosphatidylinositol 3-Kinase-Akt Signaling Pathway Regulates Myogenin Expression in Normal Myogenic Cells but Not in Rhabdomyosarcoma-derived RD Cells

    Article • Journal of Biological Chemistry, November 2000, Elsevier

    Zhenguo Wu

  64. p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps

    Article • Molecular and Cellular Biology, June 2000, ASM Journals

    Zhenguo Wu

  65. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

    Article • Genes & Development, November 1998, Cold Spring Harbor Laboratory Press

    Zhenguo Wu

  66. Mutations in domain IIIα of the mu transposase: evidence suggesting an active site component which interacts with the Mu-Host junction 1 1Edited by M. Gottesman

    Article • Journal of Molecular Biology, September 1998, Elsevier

    Zhenguo Wu

  67. Stabilization of Interleukin-2 mRNA by the c-Jun NH 2 -Terminal Kinase Pathway

    Article • Science, June 1998, American Association for the Advancement of Science

    Zhenguo Wu

  68. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.

    Article • Molecular and Cellular Biology, December 1997, ASM Journals

    Zhenguo Wu

  69. The mu transposase tetramer is inactive in unassisted strand transfer: an auto-allosteric effect of mu A promotes the reaction in the absence of mu B

    Article • Journal of Molecular Biology, March 1997, Elsevier

    Zhenguo Wu