All Stories

  1. The structural integrity of the membrane-embedded bacterial division complex FtsQBL studied with molecular dynamics simulations

    Article • Computational and Structural Biotechnology Journal, January 2023, Elsevier

    Dr. Yu Wai Chen

  2. Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism

    Article • RSC Medicinal Chemistry, January 2022, Royal Society of Chemistry

    Dr. Yu Wai Chen

  3. Interdomain flexibility and interfacial integrity of β-lactamase inhibitory protein (BLIP) modulate its binding to class A β-lactamases

    Article • Journal of Biological Chemistry, August 2021, Elsevier

    Dr. Yu Wai Chen

  4. Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Dr. Yu Wai Chen

  5. Mono-PEGylation of a Thermostable Arginine-Depleting Enzyme for the Treatment of Lung Cancer

    Article • International Journal of Molecular Sciences, June 2020, MDPI AG

    Dr. Yu Wai Chen

  6. Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CLpro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates

    Article • F1000Research, April 2020, Faculty of 1000, Ltd.

    Dr. Yu Wai Chen

  7. Hydrophobic substituents on isatin derivatives enhance their inhibition against bacterial peptidoglycan glycosyltransferase activity

    Article • Bioorganic Chemistry, April 2020, Elsevier

    Dr. Yu Wai Chen

  8. Approved drugs that may be effective on Wuhan coronavirus outbreak (COVID-19)

    Article • F1000Research, February 2020, Faculty of 1000, Ltd.

    Chin Pang Yiu, Dr. Yu Wai Chen

  9. Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers

    Article • Journal of Structural Biology, June 2019, Elsevier

    Dr. Yu Wai Chen

  10. From Disorder to Mis-Order: Structural Aspects of Pathogenic Oligomerization in Conformational Diseases

    Article • Protein and Peptide Letters, March 2017, Bentham Science Publishers

    Dr. Yu Wai Chen

  11. Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

    Article • Biochemical Journal, September 2015, Portland Press Ltd.

    Dr. Yu Wai Chen

  12. High-Quality Macromolecular Graphics on Mobile Devices: A Quick Starter’s Guide

    Article • October 2013, Springer Science + Business Media

    Dr. Yu Wai Chen

  13. Insoluble Protein Purification with Sarkosyl: Facts and Precautions

    Article • October 2013, Springer Science + Business Media

    Dr. Yu Wai Chen

  14. Structure of UreG/UreF/UreH Complex Reveals How Urease Accessory Proteins Facilitate Maturation of Helicobacter pylori Urease

    Article • PLoS Biology, October 2013, PLOS

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  15. Self-Assembly and Conformational Heterogeneity of the AXH Domain of Ataxin-1: An Unusual Example of a Chameleon Fold

    Article • Biophysical Journal, March 2013, Elsevier

    Dr. Yu Wai Chen

  16. Solution Model of the Intrinsically Disordered Polyglutamine Tract-Binding Protein-1

    Article • Biophysical Journal, April 2012, Elsevier

    Dr. Yu Wai Chen

  17. Assembly of Preactivation Complex for Urease Maturation inHelicobacter pylori

    Article • Journal of Biological Chemistry, October 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Yu Wai Chen, Prof. Kam Bo Wong, Hongzhe Sun

  18. The crystal structure of the ubiquitin-like (UbL) domain of human homologue A of Rad23 (hHR23A) protein

    Article • Protein Engineering Design and Selection, November 2010, Oxford University Press (OUP)

    Dr. Yu Wai Chen

  19. Strong, non-local interactions: the Hong Kong bond

    Article • Protein Engineering Design and Selection, October 2010, Oxford University Press (OUP)

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  20. Crystallization and preliminary crystallographic analysis of the central domain ofDrosophilaDribble, a protein that is essential for ribosome biogenesis

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, April 2010, International Union of Crystallography

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  21. Computational Resources for Protein Modelling and Drug Discovery Applications

    Article • Infectious Disorders - Drug Targets, October 2009, Bentham Science Publishers

    Dr. Yu Wai Chen

  22. Crystallization and preliminary X-ray diffraction studies of the ubiquitin-like (UbL) domain of the human homologue A of Rad23 (hHR23A) protein

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, August 2009, International Union of Crystallography

    Dr. Yu Wai Chen

  23. First Glimpse of the Peptide Presentation by Rhesus Macaque MHC Class I: Crystal Structures of Mamu-A*01 Complexed with Two Immunogenic SIV Epitopes and Insights into CTL Escape

    Article • The Journal of Immunology, January 2007, The American Association of Immunologists

    Dr. Yu Wai Chen

  24. Refolding, crystallization and preliminary X-ray structural studies of the West Nile virus envelope (E) protein domain III

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, April 2005, International Union of Crystallography

    Dr. Yu Wai Chen

  25. Rational Design of a Novel Fluorescent Biosensor for β-Lactam Antibiotics from a Class A β-Lactamase

    Article • Journal of the American Chemical Society, April 2004, American Chemical Society (ACS)

    Dr. Yu Wai Chen

  26. The Structure of the AXH Domain of Spinocerebellar Ataxin-1

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Yu Wai Chen

  27. Solution structure and thermal stability of ribosomal protein L30e from hyperthermophilic archaeonThermococcus celer

    Article • Protein Science, July 2003, Wiley

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  28. Crystal Structure of Ribosomal Protein L30e from the Extreme Thermophile Thermococcus celer:  Thermal Stability and RNA Binding,

    Article • Biochemistry, February 2003, American Chemical Society (ACS)

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  29. Local protein unfolding and pathogenesis of polyglutamine-expansion diseases

    Article • Proteins Structure Function and Bioinformatics, January 2003, Wiley

    Dr. Yu Wai Chen

  30. Site-specific mutagenesis in a homogeneous polyglutamine tract: application to spinocerebellar ataxin-3

    Article • Protein Engineering Design and Selection, January 2003, Oxford University Press (OUP)

    Dr. Yu Wai Chen

  31. Solution solution: using NMR models for molecular replacement

    Article • Acta Crystallographica Section D Biological Crystallography, September 2001, International Union of Crystallography

    Dr. Yu Wai Chen

  32. Crystallization and preliminary crystallographic studies of a ribosomal protein L30e from the hyperthermophilic archaeonThermococcus celer

    Article • Acta Crystallographica Section D Biological Crystallography, May 2001, International Union of Crystallography

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  33. Structure of the C-terminal sterile α-motif (SAM) domain of human p73α

    Article • Acta Crystallographica Section D Biological Crystallography, April 2001, International Union of Crystallography

    Dr. Yu Wai Chen

  34. A systematic case study on using NMR models for molecular replacement: p53 tetramerization domain revisited

    Article • Acta Crystallographica Section D Biological Crystallography, December 2000, International Union of Crystallography

    Dr G. Marius Clore, Dr. Yu Wai Chen

  35. Does NMR Mean “Not for Molecular Replacement”? Using NMR-Based Search Models to Solve Protein Crystal Structures

    Article • Structure, November 2000, Elsevier

    Dr. Yu Wai Chen

  36. Crystallization and preliminary crystallographic studies of a SAM domain at the C-terminus of human p73α

    Article • Acta Crystallographica Section D Biological Crystallography, June 2000, International Union of Crystallography

    Dr. Yu Wai Chen

  37. Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat

    Article • Proceedings of the National Academy of Sciences, February 1999, Proceedings of the National Academy of Sciences

    Dr. Yu Wai Chen

  38. Characterization of chemically synthesized hybrid CXC chemokines

    Article • Acta Crystallographica Section A Foundations of Crystallography, August 1996, International Union of Crystallography

    Dr. Yu Wai Chen

  39. Crystallographic analysis of Phe→Leu substitution in the hydrophobic core of barnase

    Article • Acta Crystallographica Section D Biological Crystallography, March 1995, International Union of Crystallography

    Dr. Yu Wai Chen

  40. Stability and solvation of Thr/Ser to Ala and Gly mutations at the N-cap of α-helices

    Article • FEBS Letters, June 1994, Wiley

    Dr. Yu Wai Chen

  41. Contribution of Buried Hydrogen Bonds to Protein Stability The Crystal Structures of Two Barnase Mutants

    Article • Journal of Molecular Biology, December 1993, Elsevier

    Dr. Yu Wai Chen

  42. Internet Resources for the Antibody Engineer

    Article • Springer Science + Business Media

    Dr. Yu Wai Chen