All Stories

  1. Structural insights into how metallochaperones UreE and UreG interact to deliver a toxic metal to urease

    Article • Proceedings of the National Academy of Sciences, September 2026, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  2. Arabidopsis PUB2 and PUB4 connect signaling components of pattern‐triggered immunity

    Article • New Phytologist, January 2022, Wiley

    Prof. Kam Bo Wong

  3. Structural insights into how vacuolar sorting receptors recognize the sorting determinants of seed storage proteins

    Article • Proceedings of the National Academy of Sciences, December 2021, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  4. Structural and Mutagenesis Studies Evince the Role of the Extended Protuberant Domain of Ribosomal Protein uL10 in Protein Translation

    Article • Biochemistry, August 2019, American Chemical Society (ACS)

    Prof. Kam Bo Wong

  5. Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

    Article • Toxins, August 2018, MDPI AG

    Prof. Kam Bo Wong

  6. An Adaptation of Anfinsen's Protein-Folding Experiment for Classroom Investigation

    Article • The American Biology Teacher, May 2018, University of California Press

    Prof. Kam Bo Wong

  7. FdC1 and Leaf-Type Ferredoxins Channel Electrons From Photosystem I to Different Downstream Electron Acceptors

    Article • Frontiers in Plant Science, April 2018, Frontiers

    Prof. Kam Bo Wong

  8. Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2018, Taylor & Francis

    Chun Lai Tam, Prof. Kam Bo Wong

  9. Structural insights into how GTP-dependent conformational changes in a metallochaperone UreG facilitate urease maturation

    Article • Proceedings of the National Academy of Sciences, December 2017, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  10. Using Homology Modeling to Understand the Structural Basis of Specific Interaction of a Plant-Specific AtSar1a–AtSec23a Pair Involved in Protein ER Export

    Article • January 2017, Springer Science + Business Media

    Prof. Kam Bo Wong

  11. Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins

    Article • Molecules, November 2016, MDPI AG

    Prof. Kam Bo Wong

  12. Crystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2

    Article • Toxins, October 2016, MDPI AG

    Prof. Kam Bo Wong

  13. AtPAP2 modulates the import of the small subunit of Rubisco into chloroplasts

    Article • Plant Signaling & Behavior, October 2016, Taylor & Francis

    Prof. Kam Bo Wong

  14. A single amino acid substitution in a chitinase of the legumeMedicago truncatulais sufficient to gain Nod-factor hydrolase activity

    Article • Open Biology, July 2016, Royal Society Publishing

    Prof. Kam Bo Wong

  15. Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial–mesenchymal transition and remodeling of actin cytoskeleton organization

    Article • Oncogene, June 2016, Springer Science + Business Media

    Prof. Kam Bo Wong

  16. ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses

    Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  17. Unique COPII component AtSar1a/AtSec23a pair is required for the distinct function of protein ER export in Arabidopsis thaliana

    Article • Proceedings of the National Academy of Sciences, November 2015, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  18. Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1)

    Article • Journal of Biological Chemistry, September 2015, Elsevier

    Prof. Kam Bo Wong

  19. Structures of Eukaryotic Ribosomal Stalk Proteins and Its Complex with Trichosanthin, and Their Implications in Recruiting Ribosome-Inactivating Proteins to the Ribosomes

    Article • Toxins, February 2015, MDPI AG

    Prof. Kam Bo Wong

  20. Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21WAF1 / CIP1 ) and SIRT1 genes

    Article • The Journal of Pathology, February 2015, Wiley

    Professor Franky L Chan, Prof. Kam Bo Wong

  21. The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques

    Article • Toxins, January 2015, MDPI AG

    Prof. Kam Bo Wong

  22. How Vacuolar Sorting Receptor Proteins Interact with Their Cargo Proteins: Crystal Structures of Apo and Cargo-Bound Forms of the Protease-Associated Domain from an Arabidopsis Vacuolar Sorting Receptor

    Article • The Plant Cell, September 2014, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  23. Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 2014, Elsevier

    Prof. Kam Bo Wong

  24. Structure of UreG/UreF/UreH Complex Reveals How Urease Accessory Proteins Facilitate Maturation of Helicobacter pylori Urease

    Article • PLoS Biology, October 2013, PLOS

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  25. The Nodulation Factor Hydrolase of Medicago truncatula: Characterization of an Enzyme Specifically Cleaving Rhizobial Nodulation Signals

    Article • Plant Physiology, September 2013, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  26. Solution structure of human P1*P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosome

    Article • Nucleic Acids Research, July 2013, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  27. Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases

    Article • European Journal of Medicinal Chemistry, January 2013, Elsevier

    Prof. Kam Bo Wong

  28. Maize Ribosome-Inactivating Protein Uses Lys158–Lys161 to Interact with Ribosomal Protein P2 and the Strength of Interaction Is Correlated to the Biological Activities

    Article • PLOS One, December 2012, PLOS

    Dr Kong Hung SZE, Prof. Kam Bo Wong

  29. Interaction between Hydrogenase Maturation Factors HypA and HypB Is Required for [NiFe]-Hydrogenase Maturation

    Article • PLOS One, February 2012, PLOS

    Prof. Kam Bo Wong

  30. Metallo-GTPase HypB from Helicobacter pylori and Its Interaction with Nickel Chaperone Protein HypA

    Article • Journal of Biological Chemistry, February 2012, Elsevier

    Prof. Kam Bo Wong, Chair Professor of Chemistry Hongzhe Sun

  31. Structural Basis for GTP-Dependent Dimerization of Hydrogenase Maturation Factor HypB

    Article • PLOS One, January 2012, PLOS

    Prof. Kam Bo Wong

  32. Electrostatic Contribution of Surface Charge Residues to the Stability of a Thermophilic Protein: Benchmarking Experimental and Predicted pKa Values

    Article • PLOS One, January 2012, PLOS

    Prof. Kam Bo Wong

  33. Solution structure of the dimerization domain of the eukaryotic stalk P1/P2 complex reveals the structural organization of eukaryotic stalk complex

    Article • Nucleic Acids Research, November 2011, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  34. Profiling of Substrate Specificities of 3C-Like Proteases from Group 1, 2a, 2b, and 3 Coronaviruses

    Article • PLOS One, November 2011, PLOS

    Prof. Kam Bo Wong

  35. Assembly of Preactivation Complex for Urease Maturation inHelicobacter pylori

    Article • Journal of Biological Chemistry, October 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Yu Wai Chen, Prof. Kam Bo Wong, Chair Professor of Chemistry Hongzhe Sun

  36. APOE Genotype-Function Relationship: Evidence of −491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

    Article • PLOS One, October 2011, PLOS

    Prof. Kam Bo Wong

  37. Stabilizing Salt-Bridge Enhances Protein Thermostability by Reducing the Heat Capacity Change of Unfolding

    Article • PLOS One, June 2011, PLOS

    Prof. Kam Bo Wong

  38. Structure of an essential GTPase, YsxC, fromThermotoga maritima

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, May 2011, International Union of Crystallography

    Prof. Kam Bo Wong

  39. A Rigidifying Salt-Bridge Favors the Activity of Thermophilic Enzyme at High Temperatures at the Expense of Low-Temperature Activity

    Article • PLoS Biology, March 2011, PLOS

    Dr Kong Hung SZE, Prof. Kam Bo Wong

  40. Crystallization and preliminary crystallographic analysis of the central domain ofDrosophilaDribble, a protein that is essential for ribosome biogenesis. Addendum

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2010, International Union of Crystallography

    Prof. Kam Bo Wong

  41. Strong, non-local interactions: the Hong Kong bond

    Article • Protein Engineering Design and Selection, October 2010, Oxford University Press (OUP)

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  42. Profiling of Substrate Specificity of SARS-CoV 3CLpro

    Article • PLOS One, October 2010, PLOS

    Prof. Kam Bo Wong

  43. A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells

    Article • Nucleic Acids Research, June 2010, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  44. Crystallization and preliminary crystallographic analysis of the central domain ofDrosophilaDribble, a protein that is essential for ribosome biogenesis

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, April 2010, International Union of Crystallography

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  45. Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk

    Article • Nucleic Acids Research, April 2010, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  46. The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome

    Article • Nucleic Acids Research, December 2008, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  47. The crystal structure of seabream antiquitin reveals the structural basis of its substrate specificity

    Article • FEBS Letters, August 2008, Wiley

    Prof. Kam Bo Wong

  48. Immunomodulatory and anti-SARS activities of Houttuynia cordata

    Article • Journal of Ethnopharmacology, June 2008, Elsevier

    Prof. Kam Bo Wong

  49. The C-terminal end of P proteins mediates ribosome inactivation by trichosanthin but does not affect the pokeweed antiviral protein activity

    Article • Biochemical and Biophysical Research Communications, May 2008, Elsevier

    Prof. Kam Bo Wong

  50. Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): In search of potent SARS-CoV entry inhibitors

    Article • Journal of Cellular Biochemistry, April 2008, Wiley

    Prof. Kam Bo Wong

  51. Stabilization of Beta-Propeller Phytase by Introducing Xaa→Pro and Gly→Ala Substitutions at Consensus Positions

    Article • Protein & Peptide Letters, March 2008, Bentham Science Publishers

    Prof. Kam Bo Wong

  52. Trypanosoma cruzi: High ribosomal resistance to trichosanthin inactivation

    Article • Experimental Parasitology, March 2008, Elsevier

    Prof. Kam Bo Wong

  53. Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site

    Article • Nucleic Acids Research, September 2007, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  54. Characterization of Novel Orange Fluorescent Protein Cloned from Cnidarian Tube Anemone Cerianthus sp.

    Article • Marine Biotechnology, May 2007, Springer Science + Business Media

    Prof. Kam Bo Wong

  55. Pin1 Interacts With a Specific Serine-Proline Motif of Hepatitis B Virus X-Protein to Enhance Hepatocarcinogenesis

    Article • Gastroenterology, March 2007, Elsevier

    Prof. Kam Bo Wong

  56. The Effect of Disulfide Bond on the Conformational Stability and Catalytic Activity of Beta-Propeller Phytase

    Article • Protein & Peptide Letters, February 2007, Bentham Science Publishers

    Prof. Kam Bo Wong

  57. Interaction between trichosanthin, a ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical shift perturbation and mutagenesis analyses

    Article • Nucleic Acids Research, January 2007, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  58. A high-yield one-step purification method using copper-chelating chromatography for recombinant proteins fused with maltose-binding protein

    Article • Analytical Biochemistry, November 2006, Elsevier

    Prof. Kam Bo Wong

  59. Molecular cloning and functional study of rat estrogen receptor-related receptor γ in rat prostatic cells

    Article • The Prostate, January 2006, Wiley

    Prof. Kam Bo Wong

  60. Crystallization and preliminary crystallographic analysis of human common-type acylphosphatase

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, December 2005, International Union of Crystallography

    Prof. Kam Bo Wong

  61. Effects of Charge-to-Alanine Substitutions on the Stability of Ribosomal Protein L30e from Thermococcus celer

    Article • Biochemistry, December 2005, American Chemical Society (ACS)

    Prof. Kam Bo Wong

  62. Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties

    Article • Toxicon, May 2005, Elsevier

    Prof. Kam Bo Wong

  63. Electrostatic Interactions Contribute to Reduced Heat Capacity Change of Unfolding in a Thermophilic Ribosomal Protein L30e

    Article • Journal of Molecular Biology, April 2005, Elsevier

    Prof. Kam Bo Wong

  64. Crystal Structure of a Hyperthermophilic Archaeal Acylphosphatase from Pyrococcus horikoshiiStructural Insights into Enzymatic Catalysis, Thermostability, and Dimerization,

    Article • Biochemistry, March 2005, American Chemical Society (ACS)

    Prof. Kam Bo Wong

  65. Expression and Functional Study of Estrogen Receptor-Related Receptors in Human Prostatic Cells and Tissues

    Article • The Journal of Clinical Endocrinology & Metabolism, March 2005, Endocrine Society

    Professor Franky L Chan, Prof. Kam Bo Wong

  66. Crystallization and preliminary crystallographic analysis of an acylphosphatase from the hyperthermophilic archaeonPyrococcus horikoshii

    Article • Acta Crystallographica Section D Biological Crystallography, June 2004, International Union of Crystallography

    Prof. Kam Bo Wong

  67. Crystallization and preliminary crystallographic analysis of a novel orange fluorescent protein from theCnidariatube anemoneCerianthussp.

    Article • Acta Crystallographica Section D Biological Crystallography, January 2004, International Union of Crystallography

    Prof. Kam Bo Wong

  68. Solution structure and thermal stability of ribosomal protein L30e from hyperthermophilic archaeonThermococcus celer

    Article • Protein Science, July 2003, Wiley

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  69. Substrate binding and catalysis in trichosanthin occur in different sites as revealed by the complex structures of several E85 mutants

    Article • Protein Engineering Design and Selection, June 2003, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  70. The structural basis of Trp192 and the C-terminal region in trichosanthin for activity and conformational stability

    Article • Protein Engineering Design and Selection, May 2003, Oxford University Press (OUP)

    Prof. Kam Bo Wong

  71. Structural basis for the interaction of [E160A–E189A]-trichosanthin with adenine

    Article • Toxicon, April 2003, Elsevier

    Prof. Kam Bo Wong

  72. Crystal Structure of Ribosomal Protein L30e from the Extreme Thermophile Thermococcus celer:  Thermal Stability and RNA Binding,

    Article • Biochemistry, February 2003, American Chemical Society (ACS)

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  73. Crystallization and preliminary crystallographic studies of a ribosomal protein L30e from the hyperthermophilic archaeonThermococcus celer

    Article • Acta Crystallographica Section D Biological Crystallography, May 2001, International Union of Crystallography

    Dr. Yu Wai Chen, Prof. Kam Bo Wong

  74. Protein folding from a highly disordered denatured state: The folding pathway of chymotrypsin inhibitor 2 at atomic resolution

    Article • Proceedings of the National Academy of Sciences, March 2001, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  75. Engineering of a Mini-Trichosanthin That Has Lower Antigenicity by Deleting Its C-Terminal Amino Acid Residues

    Article • Biochemical and Biophysical Research Communications, April 2000, Elsevier

    Prof. Kam Bo Wong

  76. Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding 1 1Edited by B. Honig

    Article • Journal of Molecular Biology, March 2000, Elsevier

    Prof. Kam Bo Wong

  77. Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

    Article • The EMBO Journal, February 2000, Wiley

    Prof. Kam Bo Wong

  78. Hot-spot mutants of p53 core domain evince characteristic local structural changes

    Article • Proceedings of the National Academy of Sciences, July 1999, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  79. Barstar Has a Highly Dynamic Hydrophobic Core:  Evidence from Molecular Dynamics Simulations and Nuclear Magnetic Resonance Relaxation Data

    Article • Biochemistry, July 1998, American Chemical Society (ACS)

    Prof. Kam Bo Wong

  80. Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: Description of the folding pathway

    Article • Proceedings of the National Academy of Sciences, December 1997, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  81. NMR 15 N relaxation and structural studies reveal slow conformational exchange in barstar C40/82A 1 1Edited by P. E. Wright

    Article • Journal of Molecular Biology, May 1997, Elsevier

    Prof. Kam Bo Wong

  82. Initiation sites of protein folding by NMR analysis.

    Article • Proceedings of the National Academy of Sciences, October 1996, Proceedings of the National Academy of Sciences

    Prof. Kam Bo Wong

  83. Cold Denaturation of Barstar:1H,15N and13C NMR Assignment and Characterisation of Residual Structure

    Article • Journal of Molecular Biology, June 1996, Elsevier

    Prof. Kam Bo Wong

  84. Structure/function relationship study of Gln156, Glu160 and Glu189 in the active site of trichosanthin

    Article • European Journal of Biochemistry, April 1994, Wiley

    Prof. Kam Bo Wong